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Copyright (c) 2023 Wei Guo, Li Jia, Donghui Wang, Zhenhua Wang, Ruichao Li, Zhaojun Xue
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Trop2 Promotes Vimentin Expression and Induces Epithelial Stromal Transformation, Invasion and Metastasis of Gastric Cancer Cells by Regulating β-Catenin
Corresponding Author(s) : Wei Guo
Cellular and Molecular Biology,
Vol. 69 No. 1: Issue 1
Abstract
One of the most critical biological characteristics of gastric cancer (GC) is invasion and metastasis, which is also the main factor of recurrence and drug resistance. Epithelial intermediate transformation is a biological process. Epithelial cells lose the ability to exercise their epithelial characteristics while acquiring parental characteristics. Malignant epithelial cancer cells lose their connectivity and polarity through the EMT process, change cell morphology and enhance their migration ability, so as to gain the ability of invasion and variation. In this paper, we proposed that trop2 can promote vimentin expression by regulating β - Catenin to induce the transformation and metastasis of gastric cancer cells. In this study, a control group experiment was set up to construct mkn45tr and nci-n87tr resistant cell lines. The results showed that the resistance index (RI) of mkn45tr was 31.33, P < 0.01; the resistance index (RI) of nci-n87tr was 108.23, P < 0.01. The results show that the drug resistance of gastric cancer cells will become stronger with the change of time.
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