Published: December 28, 2025

Original Research Articles

Modulatory effects of Mentha longifolia and Mentha spicata essential oils on Candida albicans biofilm formation

Mentha oils affect Candida albicans

December 28, 2025
1-9
Ayshah Alrashidi, Badria Abd El-Rahman Husin Husin, Meshari Alazmi, Safa Mustafa Ibrahim, Abdel Moneim E. Sulieman

Piezo1-mediated cellular apoptosis in breast cancer cells triggered by ultrasound and microbubbles

Piezo1 regulates apoptosis

December 28, 2025
10-15
Nina Qu, Menglu Bi, Qingkai Meng, Hexiu Liu, Jingbo Wang, Xiaoli Cao

Whole-grain millets attenuate atherosclerosis by modulating cholesterol metabolism and the FGF-2/PI3K/Akt and Wnt-1/β-catenin pathways in high-cholesterol-fed rats

Cardioprotection of millets via FGF-2 and Wnt/ꞵ catenin signaling

December 28, 2025
22-30
Haritha Rajan, Abhirami Sunitha, Mani Sebastian, Amrutha Dileep Kumar Sreeja Kumari, Salu Valsala Sasi Kumar, Helen Antony

Structure-based identification of liensinine as a natural allosteric SHP2 inhibitor with anti-proliferative activity in HepG2 cells

Liensinine as a natural SHP2 inhibitor

December 28, 2025
31-38
Beom Su Seo, Dong Oh Moon

Characterization of COVID-19 patients in clinical, epidemiological, and laboratory settings: the role of vitamin D binding protein and vitamin D level in severity

Serum vitamin D and DBP in COVID-19 patients

December 28, 2025
39-48
Aleen Sardar Al-Noori, Ahmed Mohamed Salih, Muayad Aghali Merza

Curcumin-mediated synthesis of copper-doped TiO2 nanocomposite for potentially promising antioxidant, wound healing, and anti-apoptosis

Curcumin-synthesized Cu-TiO_2 for biomedicine

December 28, 2025
49-58
Saja Zubair Dhabian, Mustafa Taher Hatem

Inhibition of the RIPK1-driven necroptotic pathway protects against hypotensive and tachycardic responses to LPS in a rat model of septic shock

Protective effects of Nec-1s against septic shock

December 28, 2025
59-71
Bahar Tunctan, Sefika Pinar Senol, Dilsah Ezgi Yilmaz, Omer Bahceli, Tuba Kara, Muhammed Ahmed-Reda Elosman

Multidimensional assessment of natural ligands fisetin, morin and rutin against factor XIIa activity using in vitro and in silico studies

Fisetin inhibits coagulation factor XIIa activity

December 28, 2025
72-80
Hassan A. Madkhali

The role of an immunohistochemical panel including CD45, CK5/6, and ER in classifying challenging breast lesions in Iraqi pathology

CD45, CK5/6 and ER in challenging breast lesions

December 28, 2025
94-100
Saman Rafeeq Abdullah

TMAO converts cytochrome c into a pro-apoptotic peroxidase by destabilizing the heme-Met80 ligation

TMAO unlocks the apoptotic activity of cytochrome c

December 28, 2025
110-117
Kuldeep Singh, Anju Kumari, Seemasundari Yumlembam, Nelson Mutum, Radhika Bakhshi, Prachi Rani, Kajal Mavi, Akshita Gupta, Laishram Rajendrakumar Singh

Activation of the Na/K-ATPase oxidant amplification loop by uremic toxins drives adipocyte dysfunction in vitro

Uremic toxins trigger Na/K-ATPase oxidant signaling

December 28, 2025
118-125
Hari Vishal Lakhani, Muhammad A. Chaudhry, Tilak Khanal, D. Blaine Nease, Joseph I. Shapiro, Komal Sodhi

Structural dynamics of PCSK9 loss-of-function variants: implications for LDL cholesterol regulation and cardiovascular risk

PCSK9 mutations: structure to heart risk

December 28, 2025
126-138
Mohammed Tarique, Ayyub Ali Patel, Ayaz Khurram Mallick, Rania A. Hussien, Tarek Mahmoud Mirdad, Zia-Ul -Sabah, Rasha Mirdad, Imad Mohammad Alghawanmeh, Mohamed Babiker Abdelrouf Awadelkarim, Mohammad Azhar Kamal, Hani Alothaid

Reviews

Toll-like receptor 3 in hepatitis B and C: a determinant of infection

TLR3 and viral hepatitis B and C

December 28, 2025
81-93
Abdoul Karim Ouattara, Issoufou Tao, Julien Dembélé, Jacques Simpore

Chronic inflammation in the development of colorectal cancer: pathological model and therapeutic targets

Inflammation-driven colorectal carcinogenesis

December 28, 2025
101-109
Alexander Blagov, Nikolay Shakhpazyan, Olga Maltseva, Elizaveta Korchagina, Alexander Orekhov

Mini Reviews

A systematic review of the toxicity of salsolinol and its metabolites

Toxicity of salsolinol and metabolites

December 28, 2025
16-21
Jasmine Kaur Sidhu, Hong Yu Wong, Beek Yoke Chin, Kenny Gah Leong Voon, Shamala Salvamani, Anna Pick Kiong Ling, Soi Moi Chye, Rhun Yian Koh