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Vol. 66 No. 3: Issue 3

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Combating sars-cov-2 through lipoxins, proteasome, caveolin and nuclear factor-κb pathways in non-pregnant and pregnant populations

https://doi.org/10.14715/cmb/2020.66.3.36
Onder Celik
1Private Clinic Obstetrics and Gynecology, Usak, Turkey
Nilufer Celik
Department of Biochemistry, Dr. Behcet Uz Children's Research and Training Hospital, Izmir, Turkey
Suleyman Aydin
Department of Medical Biochemistry, Firat University School of Medicine, Elazig, Turkey
Bora Baysal
4Department of Neonatology, Faculty of Medicine, Usak University, Usak, Turkey
Suna Aydin
Deparment of Cardiovascular Surgery, Fethi Sekin City Hospital, Elazig, Turkey
Aylin Saglam
Department of Obstetrics and Gynecology, Aksaray University School of Medicine, Aksaray, Turkey
Yagmur Gursu
Department of Family Medicine, Faculty of Medicine, Bezm-i Alem University, Istanbul, Turkey
Semih Dalkilic
Department of Molecular Biology and Genetics, Firat University Faculty of Science Elazig, Turkey
Mustafa Ulas
Department of Physiology, Firat University School of Medicine, Elazig, Turkey
Mustafa D Ozcil
Department of Obstetrics and Gynecology, Mustafa Kemal University School of Medicine, Hatay, Turkey
Ahter T Tayyar
Department of Obstetrics and Gynecology, IVF Clinic, Bahcesehir University School of Medicine, Istanbul, Turkey
Ferhat Cengiz
Department of Obstetrics and Gynecology, IVF Clinic, Bahcesehir University School of Medicine, Istanbul, Turkey
Kader Ugur
Department of Internal Medicine Firat University School of Medicine, Elazig, Turkey
Ramazan Fazil Akkoc
Department of Anatomy, Firat University School of Medicine, Elazig, Turkey
Aynur A Ersahin
Department of Internal Medicine Firat University School of Medicine, Elazig, Turkey

Corresponding Author(s) : Suleyman Aydin

saydin1@hotmail.com

Cellular and Molecular Biology, Vol. 66 No. 3: Issue 3

Abstract

It can be misleading to think that the new severe acute respiratory syndrome coronavirus (SARS-CoV2) which has a very strong mutation and adaptation capabilities, uses only the angiotensin-converting enzyme II (ACE2) pathway to reach target cells. Despite all the precautions taken, the pandemic attack continues and the rapid increase in the number of deaths suggest that this virus has entered the cell through different pathways and caused damage through different mechanisms. The main reason why the ACE2 pathway comes to the fore in all scientific studies is that this receptor is located at the entry point of basic mechanisms that provide alveolo-capillary homeostasis. SARS-CoV-2 has to use nuclear factor-κB (NF-kB), caveloae, clathrin, lipoxin, serine protease and proteasome pathways in addition to ACE2 to enter the target cell and initiate damage. For this reason, while new drug development studies are continuing, in order to be beneficial to patients in their acute period, it is imperative that we are able to come up with drugs that activate or inhibit these pathways and are currently in clinical use. It is also critical that we adopt these new pathways to the treatment of pregnant women affected by SARS-CoV-2, based on the scientific data we use to treat the general population.

Keywords

SARS-CoV-2 ACE2 Viral entry pathways Nuclear factor-κB Proteasome Lipoxin Off label drugs Serine protease.
Celik, O., Celik, N., Aydin, S., Baysal, B., Aydin, S., Saglam, A., Gursu, Y., Dalkilic, S., Ulas, M., Ozcil, M. D., Tayyar, A. T., Cengiz, F., Ugur, K., Akkoc, R. F., & Ersahin, A. A. (2020). Combating sars-cov-2 through lipoxins, proteasome, caveolin and nuclear factor-κb pathways in non-pregnant and pregnant populations. Cellular and Molecular Biology, 66(3), 221–229. https://doi.org/10.14715/cmb/2020.66.3.36
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Author Biography

Suleyman Aydin, Department of Medical Biochemistry, Firat University School of Medicine, Elazig, Turkey
Medical Biochemistry (Firat Hormones Research Group)
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