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Vol. 66 No. 1: Issue 1

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Intra-ovarian stem cell transplantation in management of premature ovarian insufficiency: towards the induced Oogonial Stem Cell (iOSC)

https://doi.org/10.14715/cmb/2019.66.1.19
Onder Celik
Private Clinic Obstetrics and Gynecology, Usak, Turkey
Mehmet Ak
Department of Obstetrics and Gynecology, Erciyes University School of Medicine, Kayseri, Turkey
Erdem Sahin
Department of Obstetrics and Gynecology, Erciyes University School of Medicine, Kayseri, Turkey
Senol Senturk
Recep Tayyip Erdogan University, Faculty of Medicine, Department of Obstetrics and Gynecology, Rize, Turkey
Kader Ugur
Department of Internal Medicine (Endocrinology and Metabolism Diseases), School of Medicine, Firat University, Elazig, Turkey
Sudenaz Celik
Kent College Guzelbahce High School, Izmir, Turkey
Nilufer Celik
Department of Biochemistry, Behcet Uz Children's Hospital, Izmir, Turkey
Ferhat Cengiz
Bahcesehir University Medical Park Hospital IVF Center, Istanbul, Turkey
Iptisam ć°pek Muderris
Department of Obstetrics and Gynecology, Erciyes University School of Medicine, Kayseri, Turkey
Metin Capar
Necmettin Erbakan University, Meram Medical School, Department of Obstetrics and Gynecology, Konya, Turkey
ć°brahim Sahin
Department of Medical Biology, Erzincan Binali Yıldırım University, School of Medicine, Erzincan, Turkey
Suleyman Aydin
Department of Medical Biochemistry, Firat University, School of Medicine, Elazig, Turkey

Corresponding Author(s) : Suleyman Aydin

saydin1@hotmail.com

Cellular and Molecular Biology, Vol. 66 No. 1: Issue 1

Abstract

The specialized resident-stem cells in gonads are tasked with restorating damaged ovarian cells following injury to maintain sequential reproductive events. When we talk about premature ovarian insufficiency (POI) we accept the existence of decreased stem cell and their regenerative abilities. The present study was to explain how restorating damaged ovarian cells following injury to maintain sequential reproductive events in evidence-based medicine indexed in PubMed and Web of Science. The exact mechanism is unclear stem cells transfer may improve compromised ovarian function and fertility outcome in women with POI. Soluble factors secreted by stem cell may rescue impaired mitochondrial function in oogonial stem cells, enhance metabolic capacity of resident stem cells, induce local neovascularization in the ovary, and activate gene shifting between transferred stem cells and germ cell precursors. This review may provide insight into how stem cells show some of their beneficial effects on compromised ovarian microenvironment and germ cell niche and paves the way for clinical trials for improving ovarian function of women with POI. We also had the opportunity to share our hypothesis about the design and development of induced oogonial stem cell (iOSC) and its use in POI.

Keywords

Oogonial stem cell Stem cell transplantation Premature ovarian insufficiency.
Celik, O., Ak, M., Sahin, E., Senturk, S., Ugur, K., Celik, S., Celik, N., Cengiz, F., Muderris, I. ć°pek, Capar, M., Sahin, ć°brahim, & Aydin, S. (2020). Intra-ovarian stem cell transplantation in management of premature ovarian insufficiency: towards the induced Oogonial Stem Cell (iOSC). Cellular and Molecular Biology, 66(1), 114–121. https://doi.org/10.14715/cmb/2019.66.1.19
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