A candidate single nucleotide polymorphism in the 3' untranslated region (rs17878624) of survivin gene for NSCLC

Engin Aynaci; Ender Coskunpinar; Pinar Yildiz

doi:10.14715/cmb/2018.64.4.20

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Vol. 64 No. 4: Issue 4

Issue Published : April 2, 2018

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A candidate single nucleotide polymorphism in the 3' untranslated region (rs17878624) of survivin gene for NSCLC

https://doi.org/10.14715/cmb/2018.64.4.20

Engin Aynaci

Department of Pulmonology, Faculty of Medicine, Medipol University, Istanbul, Turkey

Ender Coskunpinar

Department of Medical Biology, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey

Pinar Yildiz

Department of Pulmonology, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Third clinic, ć°stanbul, Turkey

Corresponding Author(s) : Ender Coskunpinar

ecoskunpinar@gmail.com

Cellular and Molecular Biology, Vol. 64 No. 4: Issue 4
Article Published : March 31, 2018

Abstract

Survivin is a gene that locates on human chromosome 17q25 and contains 142 amino acid. Survivin (BIRC5) is the first one of the found inhibitors of apoptosis proteins (IAPs) that is an important protein family and regulates apoptosis. It is expressed particularly in cancer cells. 3'UTR region of gene has components that is necessary for gene function and this region plays a critical role in the regulation of posttranscriptional regulation of the gene expression. Therefore, polymorphisms in this region may affect the function of the gene. The purpose of the study is to investigate possible relationship, that is associated with development and prognosis of the disease, between the 3 'UTR region (rs17878624) polymorphism and NSCLC in a Turkish society.

Keywords

NSCLC Survivin Gene polymorphism 3'UTR.

Aynaci, E., Coskunpinar, E., & Yildiz, P. (2018). A candidate single nucleotide polymorphism in the 3’ untranslated region (rs17878624) of survivin gene for NSCLC. Cellular and Molecular Biology, 64(4), 119–122. https://doi.org/10.14715/cmb/2018.64.4.20

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References

Park SK, Cho LY, Yang JJ, Park B, Chang SH, Lee KS, et al. Scientific Committee, Korean Academy of Tuberculosis and Respiratory Diseases. Lung cancer risk and cigarette smoking, lung tuberculosis according to histologic type and gender in a population based case-control study. Lung Cancer. 2010 Apr;68(1):20-6. doi:10.1016/j.lungcan.2009.05.017. Epub 2009 Jul 9. PubMed PMID:19545930.
Rosato A, Menin C, Boldrin D, Dalla Santa S, Bonaldi L, Scaini MC, et al. Survivin expression impacts prognostically on NSCLC but not SCLC. Lung Cancer. 2013 Feb;79(2):180-6. doi:10.1016/j.lungcan.2012.11.004. Epub 2012 Dec 4. PubMed PMID: 23218791.
Fangusaro JR, Caldas H, Jiang Y, Altura RA. Survivin: an inhibitor of apoptosis in pediatric cancer. Pediatr Blood Cancer. 2006 Jul;47(1):4-13. Review. PubMed PMID: 16534789.
Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. Biomed Res Int. 2014;2014:150845. doi:10.1155/2014/150845. Epub 2014 Jun 12. Review. PubMed PMID: 25013758; PubMed Central PMCID: PMC4075070.
Gazouli M, Tzanakis N, Rallis G, Theodoropoulos G, Papaconstantinou I, Kostakis A, et al. Survivin -31G/C promoter polymorphism and sporadic colorectal cancer. Int J Colorectal Dis. 2009 Feb;24(2):145-50. doi:10.1007/s00384-008-0601-2. Epub 2008 Oct 23. PubMed PMID: 18946675.
Wagner M, Schmelz K, Dörken B, Tamm I. Epigenetic and genetic analysis of the survivin promoter in acute myeloid leukemia. Leuk Res. 2008 Jul;32(7):1054-60. doi: 10.1016/j.leukres.2007.11.013. Epub 2008 Feb 21. PubMed PMID: 18206228.
Feng C, Yang F, Wang J. FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation. Cancer Gene Ther. 2017 Aug 4. doi: 10.1038/cgt.2017.24. [Epub ahead of print] PubMed PMID: 28776569.
Hsieh YS, Tsai CM, Yeh CB, Yang SF, Hsieh YH, Weng CJ. Survivin T9809C, an SNP located in 3'-UTR, displays a correlation with the risk and clinicopathological development of hepatocellular carcinoma. Ann Surg Oncol. 2012 Jul;19 Suppl 3:S625-33. doi: 10.1245/s10434-011-2123-3. Epub 2011 Nov 4. PubMed PMID:22052111.
Jang JS, Kim KM, Kang KH, Choi JE, Lee WK, Kim CH, et al.Polymorphisms in the survivin gene and the risk of lung cancer. Lung Cancer. 2008 Apr;60(1):31-9. Epub 2007 Oct 24. PubMed PMID:17961802.
Mallolas J, Rodríguez R, Gubern C, Camós S, Serena J, Castellanos M. A polymorphism in the promoter region of the survivin gene is related to hemorrhagic transformation in patients with acute ischemic stroke. Neuromolecular Med. 2014 Dec;16(4):856-61. doi: 10.1007/s12017-014-8333-7. Epub 2014 Oct 25. PubMed PMID: 25344020.
Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988 Feb 11;16(3):1215. PubMed PMID: 3344216; PubMed Central PMCID: PMC334765.
Drábek J, Petrek M. A sugar, laundry detergent, and salt method for extraction of deoxyribonucleic acid from blood. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2002 Dec;146(2):37-9. PubMed PMID: 12572893.
Dai J, Jin G, Dong J, Chen Y, Xu L, Hu Z, et al. Prognostic significance of survivin polymorphisms on non-small cell lung cancer survival. J Thorac Oncol. 2010 Nov;5(11):1748-54. doi: 10.1097/JTO.0b013e3181f18cb9. PubMed PMID: 20881643.
Huang CY, Lin CS, Tai WT, Hsieh CY, Shiau CW, Cheng AL, Chen KF. Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3. Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):456-62. doi:10.1016/j.ijrobp.2013.01.025. Epub 2013 Mar 6. PubMed PMID: 23474115.
Alajez NM, Lenarduzzi M, Ito E, Hui AB, Shi W, Bruce J, et al. MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res. 2011 Mar 15;71(6):2381-91. doi: 10.1158/0008-5472.CAN-10-2754. Epub 2011 Mar 8. PubMed PMID: 21385904.
Mityaev MV, Kopantzev EP, Buzdin AA, Vinogradova TV, Sverdlov ED. Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines. Biochemistry (Mosc). 2010 Feb;75(2):182-91. PubMed PMID:20367605.
Chang ET, Donahue JM, Xiao L, Cui Y, Rao JN, Turner DJ, et al. The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability. Biochem J. 2012 Aug 15;446(1):113-23. doi:10.1042/BJ20120112. PubMed PMID: 22646166; PubMed Central PMCID: PMC4118298.
Lan CC, Wu YK, Lee CH, Huang YC, Huang CY, Tsai YH, et al. Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival. Jpn J Clin Oncol. 2010 Mar;40(3):234-40. doi: 10.1093/jjco/hyp151. Epub 2009 Nov 22. PubMed PMID: 19933689.
Andre F, Schartz NE, Movassagh M, Flament C, Pautier P, Morice P, et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet. 2002 Jul 27;360(9329):295-305. PubMed PMID: 12147373.
Janviere Kabagwira and Nathan R. Wall. An Argument to Examine Exosomal Survivin Splice Variant Expression and Patient Survival in Pancreatic Cancer. Clin Oncol. 2017; 2: 1310.

References

Park SK, Cho LY, Yang JJ, Park B, Chang SH, Lee KS, et al. Scientific Committee, Korean Academy of Tuberculosis and Respiratory Diseases. Lung cancer risk and cigarette smoking, lung tuberculosis according to histologic type and gender in a population based case-control study. Lung Cancer. 2010 Apr;68(1):20-6. doi:10.1016/j.lungcan.2009.05.017. Epub 2009 Jul 9. PubMed PMID:19545930.

Rosato A, Menin C, Boldrin D, Dalla Santa S, Bonaldi L, Scaini MC, et al. Survivin expression impacts prognostically on NSCLC but not SCLC. Lung Cancer. 2013 Feb;79(2):180-6. doi:10.1016/j.lungcan.2012.11.004. Epub 2012 Dec 4. PubMed PMID: 23218791.

Fangusaro JR, Caldas H, Jiang Y, Altura RA. Survivin: an inhibitor of apoptosis in pediatric cancer. Pediatr Blood Cancer. 2006 Jul;47(1):4-13. Review. PubMed PMID: 16534789.

Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. Biomed Res Int. 2014;2014:150845. doi:10.1155/2014/150845. Epub 2014 Jun 12. Review. PubMed PMID: 25013758; PubMed Central PMCID: PMC4075070.

Gazouli M, Tzanakis N, Rallis G, Theodoropoulos G, Papaconstantinou I, Kostakis A, et al. Survivin -31G/C promoter polymorphism and sporadic colorectal cancer. Int J Colorectal Dis. 2009 Feb;24(2):145-50. doi:10.1007/s00384-008-0601-2. Epub 2008 Oct 23. PubMed PMID: 18946675.

Wagner M, Schmelz K, Dörken B, Tamm I. Epigenetic and genetic analysis of the survivin promoter in acute myeloid leukemia. Leuk Res. 2008 Jul;32(7):1054-60. doi: 10.1016/j.leukres.2007.11.013. Epub 2008 Feb 21. PubMed PMID: 18206228.

Feng C, Yang F, Wang J. FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation. Cancer Gene Ther. 2017 Aug 4. doi: 10.1038/cgt.2017.24. [Epub ahead of print] PubMed PMID: 28776569.

Hsieh YS, Tsai CM, Yeh CB, Yang SF, Hsieh YH, Weng CJ. Survivin T9809C, an SNP located in 3'-UTR, displays a correlation with the risk and clinicopathological development of hepatocellular carcinoma. Ann Surg Oncol. 2012 Jul;19 Suppl 3:S625-33. doi: 10.1245/s10434-011-2123-3. Epub 2011 Nov 4. PubMed PMID:22052111.

Jang JS, Kim KM, Kang KH, Choi JE, Lee WK, Kim CH, et al.Polymorphisms in the survivin gene and the risk of lung cancer. Lung Cancer. 2008 Apr;60(1):31-9. Epub 2007 Oct 24. PubMed PMID:17961802.

Mallolas J, Rodríguez R, Gubern C, Camós S, Serena J, Castellanos M. A polymorphism in the promoter region of the survivin gene is related to hemorrhagic transformation in patients with acute ischemic stroke. Neuromolecular Med. 2014 Dec;16(4):856-61. doi: 10.1007/s12017-014-8333-7. Epub 2014 Oct 25. PubMed PMID: 25344020.

Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988 Feb 11;16(3):1215. PubMed PMID: 3344216; PubMed Central PMCID: PMC334765.

Drábek J, Petrek M. A sugar, laundry detergent, and salt method for extraction of deoxyribonucleic acid from blood. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2002 Dec;146(2):37-9. PubMed PMID: 12572893.

Dai J, Jin G, Dong J, Chen Y, Xu L, Hu Z, et al. Prognostic significance of survivin polymorphisms on non-small cell lung cancer survival. J Thorac Oncol. 2010 Nov;5(11):1748-54. doi: 10.1097/JTO.0b013e3181f18cb9. PubMed PMID: 20881643.

Huang CY, Lin CS, Tai WT, Hsieh CY, Shiau CW, Cheng AL, Chen KF. Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3. Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):456-62. doi:10.1016/j.ijrobp.2013.01.025. Epub 2013 Mar 6. PubMed PMID: 23474115.

Alajez NM, Lenarduzzi M, Ito E, Hui AB, Shi W, Bruce J, et al. MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res. 2011 Mar 15;71(6):2381-91. doi: 10.1158/0008-5472.CAN-10-2754. Epub 2011 Mar 8. PubMed PMID: 21385904.

Mityaev MV, Kopantzev EP, Buzdin AA, Vinogradova TV, Sverdlov ED. Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines. Biochemistry (Mosc). 2010 Feb;75(2):182-91. PubMed PMID:20367605.

Chang ET, Donahue JM, Xiao L, Cui Y, Rao JN, Turner DJ, et al. The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability. Biochem J. 2012 Aug 15;446(1):113-23. doi:10.1042/BJ20120112. PubMed PMID: 22646166; PubMed Central PMCID: PMC4118298.

Lan CC, Wu YK, Lee CH, Huang YC, Huang CY, Tsai YH, et al. Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival. Jpn J Clin Oncol. 2010 Mar;40(3):234-40. doi: 10.1093/jjco/hyp151. Epub 2009 Nov 22. PubMed PMID: 19933689.

Andre F, Schartz NE, Movassagh M, Flament C, Pautier P, Morice P, et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet. 2002 Jul 27;360(9329):295-305. PubMed PMID: 12147373.

Janviere Kabagwira and Nathan R. Wall. An Argument to Examine Exosomal Survivin Splice Variant Expression and Patient Survival in Pancreatic Cancer. Clin Oncol. 2017; 2: 1310.