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A meta-analysis of association between serum iron levels and lung cancer risk
Corresponding Author(s) : Jian-Hui Huang
Cellular and Molecular Biology,
Vol. 64 No. 13: Issue 13
Abstract
Many studies conducted on the relationship between serum iron levels and lung cancer risk had produced inconsistent results. We therefore conducted a meta-analysis to determine whether serum iron levels were lower in lung cancer patients compared to those in controls.A literature survey was conducted by searching the PubMed, WanFang, CNKI, and SinoMed databases for articles published as of Mar 1, 2018. Standard mean differences (SMD) with the corresponding 95% confidence intervals (CI) were executed by Stata 12.0 software. A total of 13 publications involving 1118 lung cancer patients and 832 controls were included in our study. The combined results showed that serum iron levels in lung cancer cases had no significantly lower when compared to those in controls [summary SMD = -0.125, 95%CI= -0.439, 0.189, Z = 0.78, p for Z test= 0.435], with high heterogeneity (I2= 89.9%, P< 0.001) found. In the stratified analysis by geographic locations, consistent results were found for serum iron levels between lung cancer patients and controls both in Asian populations [summary SMD = -0.113, 95%CI= -0.471, 0.245] and European populations [summary SMD = -0.215, 95%CI= -0.835, 0.404]. Publication bias was not found when evaluated by Begg's funnel plot and Egger's regression asymmetry test.In summary, the current study showed that serum iron levels had no significant association on lung cancer risk.
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- References
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- .Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 2010;46:765-781.
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References
References
.Navarro Silvera SA, Rohan TE. Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control 2007;18:7-27.
.Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 2010;46:765-781.
.Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277-300.
.Zhang L, Lv J, Liao C. Dietary exposure estimates of 14 trace elements in Xuanwei and Fuyuan, two high lung cancer incidence areas in China. Biol Trace Elem Res 2012;146:287-292.
.Fonseca-Nunes A, Jakszyn P, Agudo A. Iron and cancer risk--a systematic review and meta-analysis of the epidemiological evidence. Cancer Epidemiol Biomarkers Prev 2014;23:12-31.
.Diez M, Arroyo M, Cerdan FJ, et al. Serum and tissue trace metal levels in lung cancer. Oncology 1989;46:230-234.
.Feng JF, Li SL. Correlation between oxidative stress and trace elements in blood of patients with cancer. Chin J of Clinic Reh 2006;10:187-190.
.Li HX, Zhang YB. The clinical significance of serum CYFRA21-1, ferritin and ferrum levels in the aged patients with lung cancer. Journal of Oncology 2001;7:156-157.
.Cheng Z, Dai LL, Kang Y, et al. Detection of trace elements of patients with lung cancers and pulmonary infections and its clinical significance. Chin J Nosocomiol 2011;21:2006-2008.
.Du FL, Li ZM, Cao MJ, et al. Determination of serum copper, zinc, magnesium and iron in patients with pulmonary tuberculosis, chronic bronchitis, pulmonary heart disease and lung cancer. J of Xi'an Med University 1996;17:348-350.
.Cobanoglu U, Demir H, Sayir F, et al. Some mineral, trace element and heavy metal concentrations in lung cancer. Asian Pac J Cancer Prev 2010;11:1383-1388.
.Zhao X, Han C, Jing J. [Relationship of serum trace elements to lung cancer and its clinical application]. Zhonghua Liu Xing Bing Xue Za Zhi 1998;19:286-289.
.Cai KF, Sun GW. Detection of serum six trace elements in 100 cases of lung cancer. Journal of Binzhou Medical College 1999;22:413-414.
.Chen ZH, Chen NJ, Chen LJ, et al. Detection of serum copper, zinc and iron in patients with lung cancer and lung infection and its clinical significance. Journal of Guangzhou Medical College 1994;12:118-119.
.He WD. Detection and Analysis of Some Trace Elements in Serum of Patients with Lung Cancer. Jiujiang Med J 1995;10:69-71.
.Yan QM, Miao GZ, Niu SF, et al. Determination of serum trace elements in lung cancer patients. Journal of Baotou Medical College 2008;24:457-459.
.Wang ZL, Zhang W, Zhang HY, et al. Determinat ion of serum trace elements and their clinical value in patients with lung cancer. Clinical Focus 2003;18:183-185.
.Zhang JH, Wu WN, Li HZ. Differential diagnosis value of detecting serum iron and nickel on patients with community- acquired pneumonia, tuberculosis and lung cancer. Gansu Medical Journal 2013;32:569-572.
.DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-188.
.Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560.
.Higgins JP, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med 2004;23:1663-1682.
.Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50:1088-1101.
.Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634.
.Zhou W, Park S, Liu G, et al. Dietary iron, zinc, and calcium and the risk of lung cancer. Epidemiology 2005;16:772-779.
.Cao H, Wang C, Chai R, et al. Iron intake, serum iron indices and risk of colorectal adenomas: a meta-analysis of observational studies. Eur J Cancer Care (Engl) 2017;26.