Matrix metalloproteinase-1 (MMP-1) rs1799750 polymorphism is associated with nasopharyngeal carcinoma (NPC) risk

L. Cao; P. Li; L. Dong

doi:10.14715/cmb/2017.63.10.1

Issue

Vol. 63 No. 10: Issue 10

Issue Published : November 1, 2017

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Matrix metalloproteinase-1 (MMP-1) rs1799750 polymorphism is associated with nasopharyngeal carcinoma (NPC) risk

https://doi.org/10.14715/cmb/2017.63.10.1

L. Cao

E.N.T. Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin, China

P. Li

E.N.T. Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin, China

L. Dong

E.N.T. Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin, China

Corresponding Author(s) : L. Cao

jinggu46doulian1@163.com

Cellular and Molecular Biology, Vol. 63 No. 10: Issue 10
Article Published : October 31, 2017

Abstract

A few studies suggested that matrix metalloproteinase 1 (MMP-1) rs1799750 polymorphism was associated with nasopharyngeal carcinoma (NPC) risk. However, other studies did not confirm this result. Thus, we did this meta-analysis to evaluate the association between MMP-1 rs1799750 polymorphism and NPC risk. We searched PubMed and EMBASE. Five studies with 1497 cases and 1643 controls were included in this meta-analysis. Subjects with MMP-1 rs1799750 polymorphism had an decreased NPC risk (OR = 0.79; 95%CI, 0.69–0.91; P = 0.0007; I2 = 70%). In the subgroup analysis by smoking, a marginally significant association was found in non-smokers (OR = 0.73, 95% CI 0.52 – 1.04, P = 0.08; I2 = 0%) but not smokers (OR = 0.59, 95% CI 0.24 – 1.42, P = 0.24; I2 = 83%). In conclusion, this meta-analysis showed that MMP-1 rs1799750 polymorphism was significantly associated with NPC risk.

Keywords

Nasopharyngeal carcinoma Matrix metalloproteinase Genetic.

Cao, L., Li, P., & Dong, L. (2017). Matrix metalloproteinase-1 (MMP-1) rs1799750 polymorphism is associated with nasopharyngeal carcinoma (NPC) risk. Cellular and Molecular Biology, 63(10), 1–3. https://doi.org/10.14715/cmb/2017.63.10.1

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References

Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005; 365(9476):2041-54.
Raab-Traub N, Flynn K, Pearson G, Huang A, Levine P, Lanier A, Pagano J. The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. Int J Cancer. 1987;39(1):25-9.
Dai W, Zheng H, Cheung AK, Lung ML. Genetic and epigenetic landscape of nasopharyngeal carcinoma. Chin Clin Oncol. 2016;5(2):16.
Song F, Wisithphrom K, Zhou J, Windsor LJ. Matrix metalloproteinase dependent and independent collagen degradation. Front Biosci. 2006; 11:3100-20.
Nasr HB, Mestiri S, Chahed K, Bouaouina N, Gabbouj S, Jalbout M, Chouchane L. Matrix metalloproteinase-1 (-1607) 1G/2G and -9 (-1562) C/T promoter polymorphisms: susceptibility and prognostic implications in nasopharyngeal carcinomas. Clin Chim Acta. 2007;384(1-2):57-63.
Zhou G, Zhai Y, Cui Y, Qiu W, Yang H, Zhang X, Dong X, He Y, Yao K, Zhang H, Peng Y, Yuan X, Zhi L, Zhang X, He F. Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma. Hum Mutat. 2007;28(11):1091-7.
Gao W, Sui J, Wang B, Li X, Zhang C, Wen S. MMP-1(-1607)1G/2G gene polymorphism and susceptibilityto nasopharyngeal carcinoma in Han population in Yunnan China. Chinese Archives of Otolaryngology-Head and Neck Surgery, 17(3), 116–120.
Kondo S, Wakisaka N, Schell MJ, Horikawa T, Sheen TS, Sato H, Furukawa M, Pagano JS, Yoshizaki T. Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer. 2005 20;115(3):368-76.
Tsai CW, Chang WS, Gong CL, Shih LC, Chen LY, Lin EY, Li HT, Yen ST, Wu CN, Bau DT. Contribution of Matrix Metallopeptidase-1 Genotypes, Smoking, Alcohol Drinking and Areca Chewing to Nasopharyngeal Carcinoma Susceptibility. Anticancer Res. 2016;36(7):3335-40.
Lu L, Sun Y, Li Y, Wan P. The polymorphism MMP1 -1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis. Tumour Biol. 2015;36:1685-93.
Zhang C, Song X, Zhu M, Shi S, Li M, Jin L, Lang J, Li G, Zheng H. Association between MMP1 -1607 1G>2G polymorphism and head and neck cancer risk: a meta-analysis. PLoS One. 2013;8:e56294.
Xiao XY, Wang XD, Zang DY. MMP1-1607 1G/2G polymorphism and lung cancer risk: a meta-analysis. Tumour Biol. 2012;33:2385-92.

References

Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005; 365(9476):2041-54.

Raab-Traub N, Flynn K, Pearson G, Huang A, Levine P, Lanier A, Pagano J. The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. Int J Cancer. 1987;39(1):25-9.

Dai W, Zheng H, Cheung AK, Lung ML. Genetic and epigenetic landscape of nasopharyngeal carcinoma. Chin Clin Oncol. 2016;5(2):16.

Song F, Wisithphrom K, Zhou J, Windsor LJ. Matrix metalloproteinase dependent and independent collagen degradation. Front Biosci. 2006; 11:3100-20.

Nasr HB, Mestiri S, Chahed K, Bouaouina N, Gabbouj S, Jalbout M, Chouchane L. Matrix metalloproteinase-1 (-1607) 1G/2G and -9 (-1562) C/T promoter polymorphisms: susceptibility and prognostic implications in nasopharyngeal carcinomas. Clin Chim Acta. 2007;384(1-2):57-63.

Zhou G, Zhai Y, Cui Y, Qiu W, Yang H, Zhang X, Dong X, He Y, Yao K, Zhang H, Peng Y, Yuan X, Zhi L, Zhang X, He F. Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma. Hum Mutat. 2007;28(11):1091-7.

Gao W, Sui J, Wang B, Li X, Zhang C, Wen S. MMP-1(-1607)1G/2G gene polymorphism and susceptibilityto nasopharyngeal carcinoma in Han population in Yunnan China. Chinese Archives of Otolaryngology-Head and Neck Surgery, 17(3), 116–120.

Kondo S, Wakisaka N, Schell MJ, Horikawa T, Sheen TS, Sato H, Furukawa M, Pagano JS, Yoshizaki T. Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer. 2005 20;115(3):368-76.

Tsai CW, Chang WS, Gong CL, Shih LC, Chen LY, Lin EY, Li HT, Yen ST, Wu CN, Bau DT. Contribution of Matrix Metallopeptidase-1 Genotypes, Smoking, Alcohol Drinking and Areca Chewing to Nasopharyngeal Carcinoma Susceptibility. Anticancer Res. 2016;36(7):3335-40.

Lu L, Sun Y, Li Y, Wan P. The polymorphism MMP1 -1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis. Tumour Biol. 2015;36:1685-93.

Zhang C, Song X, Zhu M, Shi S, Li M, Jin L, Lang J, Li G, Zheng H. Association between MMP1 -1607 1G>2G polymorphism and head and neck cancer risk: a meta-analysis. PLoS One. 2013;8:e56294.

Xiao XY, Wang XD, Zang DY. MMP1-1607 1G/2G polymorphism and lung cancer risk: a meta-analysis. Tumour Biol. 2012;33:2385-92.

Author biographies is not available.