Angiotensin-converting enzyme (ACE) I/D polymorphism is a risk factor of allergic rhinitis

P. Li; L. Cao; X. Han

doi:10.14715/cmb/2017.63.8.11

Issue

Vol. 63 No. 8: Issue 8

Issue Published : September 4, 2017

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Angiotensin-converting enzyme (ACE) I/D polymorphism is a risk factor of allergic rhinitis

https://doi.org/10.14715/cmb/2017.63.8.11

P. Li

E.N.T. Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin, China

L. Cao

E.N.T. Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin, China

X. Han

Department of Renal medicine, Jilin Province People's Hospital, Changchun 130021, Jilin, China

Corresponding Author(s) : P. Li

jiangwei95panhui@163.com

Cellular and Molecular Biology, Vol. 63 No. 8: Issue 8
Article Published : August 30, 2017

Abstract

Some previous studies and meta-analysis investigated the association between ACE I/D polymorphism and allergic rhinitis risk. However, the results were conflicting. This meta-analysis, therefore, was performed to evaluate the association between ACE I/D polymorphism and allergic rhinitis risk. Online electronic databases (PubMed and EMBASE) were searched. The strength was evaluated by calculating the OR and 95% CI. Five studies were finally included in this meta-analysis. These studies included 681 cases and 629 controls. ACE I/D polymorphism was significantly associated with allergic rhinitis risk (OR = 1.17; 95% CI 1.07 – 1.29; P = 0.001). In the subgroup analysis of race, Asians showed the increased allergic rhinitis risk (OR = 1.15; 95% CI 1.02 – 1.30; P = 0.03). In a stratified analysis by age, adults with ACE I/D polymorphism showed the increased allergic rhinitis risk (OR = 1.16; 95% CI 1.04 – 1.29; P = 0.006). However, children did not have the significantly increased allergic rhinitis risk (OR = 1.24; 95% CI 0.99 – 1.56; P = 0.06). In conclusion, this meta-analysis indicated that ACE I/D polymorphism was significantly associated with allergic rhinitis risk.

Keywords

Allergic rhinitis ACE Risk.

Li, P., Cao, L., & Han, X. (2017). Angiotensin-converting enzyme (ACE) I/D polymorphism is a risk factor of allergic rhinitis. Cellular and Molecular Biology, 63(8), 48–50. https://doi.org/10.14715/cmb/2017.63.8.11

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References

Bernstein DI, Schwartz G, Bernstein JA. Allergic Rhinitis: Mechanisms and Treatment. Immunol Allergy Clin North Am. 2016; 36(2):261-78.
Riordan JF. Angiotensin-I-converting enzyme and its relatives. Genome Biol. 2003; 4(8):225.
Dalbeth N, Edwards J, Fairchild S, Callan M, Hall FC. The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford). 2005; 44(1):24-31.
Gawlik R, Grzanka A, Jawor B, Czecior E. Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid. Postepy Dermatol Alergol. 2016;33(4):269-75.
Shirasaki H, Kanaizumi E, Himi T. Immunohistochemical localization of the bradykinin B1 and B2 receptors in human nasal mucosa. Mediators Inflamm. 2009;2009:102406.
Holla L, Vasku A, Znojil V, Siskova L, Vacha J. Associationof 3 gene polymorphisms with atopic diseases. J Allergy ClinImmunol. 1999;103:702-8.
Lue KH, Ku MS, Li C, Sun HL, Lee HS, Chou MC. ACE gene poly-morphism might disclose why some Taiwanese children withallergic rhinitis develop asthma symptoms but others do not.Pediatr Allergy Immunol. 2006;17:508-13.
Kim JJ, Kim HJ, Lee IK, Chung HT, Lee JH. Associationbetween polymorphisms of the angiotensin-converting enzymeand angiotensinogen genes and allergic rhinitis in a Korean pop-ulation. Ann Otol Rhinol Laryngol. 2004;113:297-302.
Wang QJ, Fan SG, Lu JP, Li MX. The relationship betweenangiotensin converting enzyme gene polymorphism and allergicrhinitis. J Mod Clin Med Bioeng. 2005;11:437-8.
Ku MS, Lue KH, Li C, Sun HL, Chou MC. Association between angiotensin-converting enzyme gene polymorphism and childhood allergic rhinitis in Taiwan. J Microbiol Immunol Infect. 2006;39(4):297-301.
Guo M, Ma J, Han Y, Lu L. Angiotensin-converting enzyme gene insertion/deletion polymorphisms and the susceptibility to allergic rhinitis. Allergol Immunopathol (Madr). 2014;42(6):568-72.
Lin H, Lin D, Zheng CQ. Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: evidence from 1410 subjects. J Renin Angiotensin Aldosterone Syst. 2014;15(4):593-600.
Huang RF, Dong P, Zhang TZ, Ying XJ, Hu H. Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to allergic rhinitis in Chinese populations: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2016;273(2):277-83.
Yang H, Mo T, Nie W, Li B. Angiotensin converting enzyme I/D polymorphism and sarcoidosis risk. Sarcoidosis Vasc Diffuse Lung Dis. 2016;32(4):284-8.
Ai JW, Liu Y, Zeng XT, Lei Q, Zou L, Pei B. Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism and Vesicoureteral Reflux in Children: A Meta-Analysis of 14 Case-Control Studies. Medicine (Baltimore). 2015;94(52):e2421.
Miao HW, Gong H. Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 2015;16(4):844-50.
Ma R, Li X, Su G, Hong Y, Wu X, Wang J, Zhao Z, Song Y, Ma S. Angiotensin-converting enzyme insertion/deletion gene polymorphisms associated with risk of atrial fibrillation: A meta-analysis of 23 case-control studies. J Renin Angiotensin Aldosterone Syst. 2015;16(4):793-800.
Wan D, Wang C, Zhang X, Tang W, Chen M, Dong Z, Yu S. Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis. Int J Neurosci. 2016;126(5):393-9.
Yang H, Cai C, Ye L, Rao Y, Wang Q, Hu D, Huang X. The relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive cancer risk: Insights from a meta-analysis. J Renin Angiotensin Aldosterone Syst. 2015;16(4):1306-13.

References

Bernstein DI, Schwartz G, Bernstein JA. Allergic Rhinitis: Mechanisms and Treatment. Immunol Allergy Clin North Am. 2016; 36(2):261-78.

Riordan JF. Angiotensin-I-converting enzyme and its relatives. Genome Biol. 2003; 4(8):225.

Dalbeth N, Edwards J, Fairchild S, Callan M, Hall FC. The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford). 2005; 44(1):24-31.

Gawlik R, Grzanka A, Jawor B, Czecior E. Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid. Postepy Dermatol Alergol. 2016;33(4):269-75.

Shirasaki H, Kanaizumi E, Himi T. Immunohistochemical localization of the bradykinin B1 and B2 receptors in human nasal mucosa. Mediators Inflamm. 2009;2009:102406.

Holla L, Vasku A, Znojil V, Siskova L, Vacha J. Associationof 3 gene polymorphisms with atopic diseases. J Allergy ClinImmunol. 1999;103:702-8.

Lue KH, Ku MS, Li C, Sun HL, Lee HS, Chou MC. ACE gene poly-morphism might disclose why some Taiwanese children withallergic rhinitis develop asthma symptoms but others do not.Pediatr Allergy Immunol. 2006;17:508-13.

Kim JJ, Kim HJ, Lee IK, Chung HT, Lee JH. Associationbetween polymorphisms of the angiotensin-converting enzymeand angiotensinogen genes and allergic rhinitis in a Korean pop-ulation. Ann Otol Rhinol Laryngol. 2004;113:297-302.

Wang QJ, Fan SG, Lu JP, Li MX. The relationship betweenangiotensin converting enzyme gene polymorphism and allergicrhinitis. J Mod Clin Med Bioeng. 2005;11:437-8.

Ku MS, Lue KH, Li C, Sun HL, Chou MC. Association between angiotensin-converting enzyme gene polymorphism and childhood allergic rhinitis in Taiwan. J Microbiol Immunol Infect. 2006;39(4):297-301.

Guo M, Ma J, Han Y, Lu L. Angiotensin-converting enzyme gene insertion/deletion polymorphisms and the susceptibility to allergic rhinitis. Allergol Immunopathol (Madr). 2014;42(6):568-72.

Lin H, Lin D, Zheng CQ. Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: evidence from 1410 subjects. J Renin Angiotensin Aldosterone Syst. 2014;15(4):593-600.

Huang RF, Dong P, Zhang TZ, Ying XJ, Hu H. Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to allergic rhinitis in Chinese populations: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2016;273(2):277-83.

Yang H, Mo T, Nie W, Li B. Angiotensin converting enzyme I/D polymorphism and sarcoidosis risk. Sarcoidosis Vasc Diffuse Lung Dis. 2016;32(4):284-8.

Ai JW, Liu Y, Zeng XT, Lei Q, Zou L, Pei B. Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism and Vesicoureteral Reflux in Children: A Meta-Analysis of 14 Case-Control Studies. Medicine (Baltimore). 2015;94(52):e2421.

Miao HW, Gong H. Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 2015;16(4):844-50.

Ma R, Li X, Su G, Hong Y, Wu X, Wang J, Zhao Z, Song Y, Ma S. Angiotensin-converting enzyme insertion/deletion gene polymorphisms associated with risk of atrial fibrillation: A meta-analysis of 23 case-control studies. J Renin Angiotensin Aldosterone Syst. 2015;16(4):793-800.

Wan D, Wang C, Zhang X, Tang W, Chen M, Dong Z, Yu S. Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis. Int J Neurosci. 2016;126(5):393-9.

Yang H, Cai C, Ye L, Rao Y, Wang Q, Hu D, Huang X. The relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive cancer risk: Insights from a meta-analysis. J Renin Angiotensin Aldosterone Syst. 2015;16(4):1306-13.

Author biographies is not available.