Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease

E Kazemi; M-T Moradi; K Yari; S A R Mousavi; D Kahrizi

Issue

Vol. 61 No. 8: Issue 8

Issue Published : December 30, 2015

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Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease

E Kazemi

Kermanshah University of Medical Sciences Medical Biology Research Center Kermanshah Iran

M-T Moradi

Kermanshah University of Medical Sciences Fertility and Infertility Research Center Kermanshah Iran

K Yari

Kermanshah University of Medical Sciences Medical Biology Research Center Kermanshah Iran

S A R Mousavi

The Scripps Research Institute Howard Hughes Medical Institute, Molecular and Cellular Neuroscience La Jolla USA

D Kahrizi

Incubator Center of Razi University Zagros Bioidea Laboratory Kermanshah Iran

Corresponding Author(s) : E Kazemi

Cellular and Molecular Biology, Vol. 61 No. 8: Issue 8
Article Published : December 19, 2015

Abstract

Generalized aggressive periodontitis (GAP) is a subtype of periodontal diseases that characterized by rapid destruction of periodontal supporting tissues. The MnSOD Val-9Ala mutation of manganese superoxide dismutase gene (MnSOD Val-9Ala) and its correlation with periodontal diseases has been studied in different populations. The purpose of this study was to investigate the possible association of MnSODVal-9Ala polymorphism with periodontitis disease in sample of GAP patients in Iran for the first time. Following a GAP examination, 50 GAP patients and 100 healthy individuals were recruited. Genomic DNA was extracted from peripheral blood leukocytes and the MnSODVal-9Ala polymorphismwas detected using PCR-RFLP method. The frequency of Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 25, 66 and 9%, respectively. In periodontitis patients, frequencies were as Ala/Ala (12%), Ala/Val (50%) and Val/Val (38%) genotypes. There was a significant positive association between distribution of MnSOD Val-9Ala genotypes and the risk of periodontitis disease (p<0.05). Our results indicated that MnSOD Val-9Ala gene polymorphism has a positive association with the risk of periodontitis disease.

Keywords

MnSOD Val-9Ala Aggressive periodontitis Gene polymorphism Iranian population.

Kazemi, E., Moradi, M.-T., Yari, K., Mousavi, S. A. R., & Kahrizi, D. (2015). Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease. Cellular and Molecular Biology, 61(8), 49–52. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/757