AIM2 inflammasome is dispensable for the host defense against Pseudomonas aeruginosa infection
Corresponding Author(s) : Z Pang
Cellular and Molecular Biology,
Vol. 61 No. 3: Issue 3
Respiratory tract infection with Pseudomonas aeruginosa is a major cause of hospital-acquired pneumonia in immune-compromised individuals. Lung infection with P. aeruginosa is often associated with production of various inflammatory cytokines including IL-1Î². Production of IL-1Î² requires proteolytic cleavage by a multiprotein complex termed inflammasome. AIM2 inflammasome recognizes foreign cytosolic double stranded DNA. A role of AIM2 in P. aeruginosa infection has not been reported previously. In this study, we found that P. aeruginosa infection induced degradation of AIM2 protein in macrophages and induction of AIM2 mRNA expression in macrophages and in the lung of mice. Interestingly, P. aeruginosa infection induced a similar level of IL-1Î², IL-6 and TNF production in wild-type and AIM2-deficient mice. Similarly, no significant differences in bacterial clearance, neutrophil infiltration and NF-ÎºB activation were observed between wild-type and AIM2-deficient mice following P. aeruginosa lung infection. Our data suggest that AIM2 inflammasome is dispensable for the host defense against P. aeruginosa infection.
Pseudomonas aeruginosa AIM2 inflammasome respiratory infection macrophage.
Pang, Z., Sun, G., Junkins, R. D., & Lin, T. (2015). AIM2 inflammasome is dispensable for the host defense against Pseudomonas aeruginosa infection. Cellular and Molecular Biology, 61(3), 63–70. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/671
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