Issue
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
AIM2 inflammasome is dispensable for the host defense against Pseudomonas aeruginosa infection
Corresponding Author(s) : Z Pang
Cellular and Molecular Biology,
Vol. 61 No. 3: Issue 3
Abstract
Respiratory tract infection with Pseudomonas aeruginosa is a major cause of hospital-acquired pneumonia in immune-compromised individuals. Lung infection with P. aeruginosa is often associated with production of various inflammatory cytokines including IL-1β. Production of IL-1β requires proteolytic cleavage by a multiprotein complex termed inflammasome. AIM2 inflammasome recognizes foreign cytosolic double stranded DNA. A role of AIM2 in P. aeruginosa infection has not been reported previously. In this study, we found that P. aeruginosa infection induced degradation of AIM2 protein in macrophages and induction of AIM2 mRNA expression in macrophages and in the lung of mice. Interestingly, P. aeruginosa infection induced a similar level of IL-1β, IL-6 and TNF production in wild-type and AIM2-deficient mice. Similarly, no significant differences in bacterial clearance, neutrophil infiltration and NF-κB activation were observed between wild-type and AIM2-deficient mice following P. aeruginosa lung infection. Our data suggest that AIM2 inflammasome is dispensable for the host defense against P. aeruginosa infection.
Keywords
Pseudomonas aeruginosa
AIM2 inflammasome
respiratory infection
macrophage.
Pang, Z., Sun, G., Junkins, R. D., & Lin, T. (2015). AIM2 inflammasome is dispensable for the host defense against Pseudomonas aeruginosa infection. Cellular and Molecular Biology, 61(3), 63–70. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/671
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX