Alexander V. Blagov; Varvara A. Orekhova; Vasily N. Sukhorukov; Anton Y. Postnov; Igor A. Sobenin; Alexander N. Orekhov

doi:10.14715/cmb/2024.70.5.24

Issue

Vol. 70 No. 5: Issue 5

Issue Published : May 27, 2024

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Influence of antibiotics on the development of mitochondrial dysfunction

Antibiotics and mitochondrial dysfunction

https://doi.org/10.14715/cmb/2024.70.5.24

Alexander V. Blagov

Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow 125315, Russia

Varvara A. Orekhova

Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, Moscow 119991, Russia

Vasily N. Sukhorukov

Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, Moscow 119991, Russia

Anton Y. Postnov

Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, Moscow 119991, Russia

Igor A. Sobenin

Laboratory of Medical Genetics, Institute of Experimental Cardiology, National Medical Research Center of Cardiology, 15a 3rd Cherepkovskaya Street, 121552 Moscow, Russia

Alexander N. Orekhov

Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, Moscow 119991, Russia

Corresponding Author(s) : Alexander V. Blagov

al.blagov2014@gmail.com

Cellular and Molecular Biology, Vol. 70 No. 5: Issue 5
Article Published : May 27, 2024

Abstract

Antibiotics are an indispensable component of therapeutic strategies in the treatment of severe bacterial infections. Unfortunately, in addition to the emerging resistance of bacteria to antibiotics, side effects are an important problem with their use. Knowledge of the mechanisms underlying the development of side effects can make it possible to understand how it is possible to reduce their negative impact on the health of patients. One of the negative effects of antibiotics on the human organism is interference with homeostasis and the functioning of mitochondria. Side effects of antibiotics based on this influence require further study. Here we consider the mitochondria as a side target of antibiotics and the main strategies of antibiotics that cause mitochondrial dysfunction. Options are also considered on how to deal with this problem and even use it for good.

Keywords

Antibiotics Oxidative stress Mitochondria Tetracyclines Aminoglycosides

Blagov, A. V., Orekhova, V. A., Sukhorukov, V. N., Postnov, A. Y., Sobenin, I. A., & Orekhov, A. N. (2024). Influence of antibiotics on the development of mitochondrial dysfunction: Antibiotics and mitochondrial dysfunction. Cellular and Molecular Biology, 70(5), 170–177. https://doi.org/10.14715/cmb/2024.70.5.24