Weibing Zhong; Lin Wang; Lingbing Xiong

doi:10.14715/cmb/2023.69.8.5

Issue

Vol. 69 No. 8: Issue 8

Issue Published : September 15, 2023

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Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression

Circ_0006251 in vascular smooth muscle cells in CAD

https://doi.org/10.14715/cmb/2023.69.8.5

Weibing Zhong

Department 2 of Cardiovascular, Nanchang People's Hospital, Nanchang 330000, Jiangxi Province, China

Lin Wang

Department of Pharmacy, Ji'an Central People's Hospital, Ji'an 343000, Jiangxi Province, China

Lingbing Xiong

Department 2 of Cardiovascular, Nanchang People's Hospital, Nanchang 330000, Jiangxi Province, China

Corresponding Author(s) : Lingbing Xiong

cuichuangsha764463@163.com

Cellular and Molecular Biology, Vol. 69 No. 8: Issue 8
Article Published : August 31, 2023

Abstract

Coronary artery disease (CAD) is a serious global problem that has been considered to be a major cause of death. Circular RNAs (circRNAs) as a key player in the regulation of cardiac progression and disease. Nevertheless, most circRNAs are poorly understood. In our research, we discussed the circ_TET3 (circ_0006251) function in the development of CAD. Firstly, circ_0006251 expression was measured through RT-qPCR analysis. Functional results prove the clear functionality of circ_0006251 for CAD. In addition, mechanism experiments including RIP, RNA pull-down and luciferase reporter results were applied to delve into the mechanisms of regulation of circ_0006251 in CAD. Results showed that Circ_0006251 expression was notably increased in PDGF-BB-induced VSMCs cells. Moreover, circ_0006251 interference mitigated the VSMCs cells proliferation and stimulated apoptosis after being treated with PDGF-BB. Furthermore, circ_0006251 targeted TET3 and PPM1B via sponging miR-361-3p, thereby contributing to CAD occurrence. In conclusion, Circ_0006251 could be identified as a biomarker for CAD which might shed light on the diagnosis and therapy of CAD.

Keywords

Coronary artery disease circ_0006251 miR-361-3p PPM1B TET3

Zhong, W., Wang, L., & Xiong, L. (2023). Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression: Circ_0006251 in vascular smooth muscle cells in CAD. Cellular and Molecular Biology, 69(8), 34–39. https://doi.org/10.14715/cmb/2023.69.8.5