Hasna  Azmi; Imane  Saif; Kawtar  Nabil; Mohammed  El Mzibri; Saber  Boutayeb; Ramin  Lak; Moulay Mustapha Ennaji Ennaji

doi:10.14715/cmb/2022.68.12.15

Issue

Vol. 68 No. 12: Issue 12

Issue Published : May 2, 2023

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Human papilloma virus profiles in breast cancer in correlation with Vitamin D

papilloma virus in breast cancer and status of vitamin D

https://doi.org/10.14715/cmb/2022.68.12.15

Hasna Azmi

Team of Virology, Oncology, and Biotechnology, Laboratory of Virology, Oncology, Biosciences, Environment and New Energies (LVO BEEN), Faculty of Science and Technology, Mohammedia, Hassan II University of Casablanca, Morocco

Imane Saif

Kawtar Nabil

Mohammed El Mzibri

Medical and Biology Research Unit. National Centre of Energy, Nuclear Sciences and Techniques, Rabat, Morocco

Saber Boutayeb

National Institute of Oncology, Rabat, Morocco

Ramin Lak

Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran

Moulay Mustapha Ennaji Ennaji

Corresponding Author(s) : Moulay Mustapha Ennaji Ennaji

m.ennaji@yahoo.fr

Cellular and Molecular Biology, Vol. 68 No. 12: Issue 12
Article Published : December 31, 2022

Abstract

The major roles of vitamin D in the genesis of breast cancer and as an immunomodulator against acute and chronic infections have been the subject of much research in recent years. A low vitamin D status could decrease the function of blocking the cell multiplication cycle of the cancer process and weaken the immune system. In this context, we were interested in the implication of vitamin D status in women with human papilloma virus (HPV)-induced breast cancer. Our study included 63 women, 53 with breast cancer and 10 healthy women, and we measured the plasma 25(OH)D3 level and looked for the presence of HPV by PCR in our population. 90.6% had low serum 25(OH)D3 levels and HPV was found in 41% of cases. In this regard, the data in the literature are discordant. Vitamin D status could explain the concomitance of the two conditions, breast cancer and HPV; it would be desirable to broaden the sample in order to better define its impact.

Keywords

Vitamin D, Human papilloma virus (HPV), Breast cancer, VDR

Azmi, H. ., Saif, I. ., Nabil, K. ., El Mzibri, M. ., Boutayeb, S. ., Lak, R. ., & Ennaji, M. M. E. (2022). Human papilloma virus profiles in breast cancer in correlation with Vitamin D: papilloma virus in breast cancer and status of vitamin D. Cellular and Molecular Biology, 68(12), 79–83. https://doi.org/10.14715/cmb/2022.68.12.15