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Vol. 66 No. 6: Issue 6

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Diagnostic and methodological evaluation of studies on the urinary shedding of SARS-CoV-2, compared to stool and serum: A systematic review and meta-analysis

https://doi.org/10.14715/cmb/2020.66.6.26
Mohammad Reza Roshandel
Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA
Masoud Nateqi
Center for Biotechnology and Genomics, Texas Tech University, Lubbock, TX, USA
Ramin Lak
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran
Pooya Aavani
Department of Biology, Emory University, Atlanta, Georgia, USA
Reza Sari Motlagh
Urology Department of Medical University of Vienna, Austria
Shahrokh F. Shariat
Urology Department of Medical University of Vienna, Austria
Tannaz Aghaei Badr
Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA
John Sfakianos
Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA
Steven A Kaplan
Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA
Ashutosh K Tewari
Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA

Corresponding Author(s) : Ashutosh K Tewari

ashtewari@mountsinai.org

Cellular and Molecular Biology, Vol. 66 No. 6: Issue 6

Abstract

Investigating the infectivity of body fluid can be useful for preventative measures in the community and ensuring safety in the operating rooms and on the laboratory practices. We performed a literature search of clinical trials, cohorts, and case series using PubMed/MEDLINE, Google Scholar, and Cochrane library, and downloadable database of CDC. We excluded case reports and searched all-language articles for review and repeated until the final drafting. The search protocol was registered in the PROSPERO database. Thirty studies with urinary sampling for viral shedding were included. A total number of 1,271 patients were enrolled initially, among which 569 patients had undergone urinary testing. Nine studies observed urinary viral shedding in urine from 41 patients. The total incidence of urinary SARS-CoV-2 shedding was 8%, compared to 21.3% and 39.5 % for blood and stool, respectively. The summarized risk ratio (RR) estimates for urine positive rates compared to the pharyngeal rate was 0.08. The pertaining RR urine compared to blood and stool positive rates were 0.20 and 0.33, respectively. Our review concludes that not only the SARS-CoV-2 can be excreted in the urine in eight percent of patients but also its incidence may have associations with the severity of the systemic disease, ICU admission, and fatality rates. Moreover, the findings in our review suggest that a larger population size may reveal more positive urinary cases possibly by minimizing biases.

Keywords

SARS-CoV-2 COVID-19 Urine Real-time RT-PCR Infection.
Roshandel, M. R., Nateqi, M., Lak, R., Aavani, P., Sari Motlagh, R., F. Shariat, S., Aghaei Badr, T., Sfakianos, J., Kaplan, S. A., & Tewari, A. K. (2020). Diagnostic and methodological evaluation of studies on the urinary shedding of SARS-CoV-2, compared to stool and serum: A systematic review and meta-analysis. Cellular and Molecular Biology, 66(6), 148–156. https://doi.org/10.14715/cmb/2020.66.6.26
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Author Biographies

John Sfakianos, Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA
Urology department
Steven A Kaplan, Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA
Urology department
Ashutosh K Tewari, Urology Department of Icahn School of Medicine, Mount Sinai Hospitals, NY, USA
Urology department
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