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Copyright (c) 2022 Hongli Gao, Lingling Yang, YiShun Shao
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.SIRT1 / NF-κB pathway on neuronal apoptosis in rats with ischemic stroke
Corresponding Author(s) : YiShun Shao
Cellular and Molecular Biology,
Vol. 68 No. 5: Issue 5
Abstract
Recent studies have shown that neuronal apoptosis is one of the important mechanisms leading to cerebral ischemic injury. SIRT1/NF-κB is a carrier of protein units in the body, participates in the synthesis of DNA, RNA and important neurotransmitters in the brain, and is an important nutrient necessary to maintain the normal growth and development of the nervous system and the normal function of cells. This article aims to study the effect of the SIRT1/NF-κB pathway on neuronal apoptosis in rats with ischemic stroke. Rats were divided into sham operation group, model group, SIRT1/NF-κB group, each group was given intragastric administration at different doses 3 days before the operation and after the operation, and brain tissue was taken at 24, 48, 72, 96 h after operation HE staining, TTC staining and dynamic changes of SIRT1/NF-κB expression were measured. The results of the experiment showed that the result of Nao Xintong was low, and the SIRT1/NF-κB group could reduce the volume of cerebral infarction in rats (P <0.05), and reduce the expression of SIRT1/NF-κB positive cells. The experimental results show that Naoxintong SIRT1/NF-κB has a protective effect on neuronal apoptosis after focal cerebral ischemia-reperfusion in rats.
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