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Copyright (c) 2022 Zhenyu Wu, Shaohua Gong, Yuxin Zheng, He Liang
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.The inhibitory effect of neurotropin on inflammation in rats with lumbar disc herniation based on the c-JNK/CXCL1 signaling pathway
Corresponding Author(s) : He Liang
Cellular and Molecular Biology,
Vol. 68 No. 2: Issue 2
Abstract
This study aimed to investigate the inhibitory effect and mechanism of neurotropin on inflammation in rats with lumbar disc herniation. For this purpose, forty-eight rats were randomly divided into sham group, autologous nucleus pulposus transplantation model group (NP group), neurotropin treatment group (NP+NT group), and solvent [normal saline (NS)] control group (NP+NS group). After 7 days of intervention, the mechanical paw withdrawal threshold (PWT) and thermal paw withdrawal latency (PWL) of the rats were measured, and the expression levels of Iba-1, c-JNK and CXCL1 in spinal cord tissues were measured by Western blot. The levels of tissue-associated inflammatory and anti-inflammatory factors in the spinal cord were detected by ELISA. Results showed that Neurotropin significantly alleviated mechanical and thermal hyperalgesia induced by NP transplantation and reduced levels of Iba-1, c-JNK, and CXCL1 proteins in the spinal cord tissue. In addition, neurotoxins also lowered concentrations of the inflammatory factors IL-1β, IL-6 and TNF-α. It was concluded that Neurotropin has an inhibitory effect on lumbar disc herniation-induced spinal cord inflammation through inhibition of the c-JNK/CXCL signaling pathway.
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