Mehran Alavi; Musa  Moetasam Zorab; Morahem  Ashengroph; Qassim Hassan Aubais  Aljelehawy; Danial Kahrizi

doi:10.14715/cmb/2022.68.3.2

Issue

Vol. 68 No. 3: New findings of cellular, molecular, and medical biology using nanotechnology

Issue Published : August 9, 2022

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Antibacterial and wound healing applications of curcumin in micro and nano-scaffolds based on chitosan, cellulose, and collagen

Antibacterial and wound healing applications of curcumin in micro and nano-scaffolds

https://doi.org/10.14715/cmb/2022.68.3.2

Mehran Alavi

Nanobiotechnology Department, Faculty of innovative Science and Technology, Razi University, Kermanshah, Iran

Musa Moetasam Zorab

Department of Physics, University of Halabja, Kurdistan Region, Iraq

Morahem Ashengroph

Department of Biological Science, Faculty of Science, University of Kurdistan, Kurdistan, Sanandaj, Iran

Qassim Hassan Aubais Aljelehawy

Danial Kahrizi

Nanobiotechnology Laboratory, Biology Department, Faculty of Science, Razi University, Kermanshah, Iran

Corresponding Author(s) : Morahem Ashengroph

m.ashengroph@uok.ac.ir

Cellular and Molecular Biology, Vol. 68 No. 3: New findings of cellular, molecular, and medical biology using nanotechnology
Article Published : March 31, 2022

Abstract

About 80% higher risk of amputation resulted from microbial infection was indicated for patients with diabetic foot ulcers (DFUs). Micro and nano-scaffolds made of natural polymers specifically cellulose, chitosan, and collagen can donate the biocompatibility, biodegradability, and bioavailability properties appropriate to accelerate wound closure before microbial biofilm formation. Antimicrobial activity of these wound dressings can be improved by incorporation of bioactive compounds extracted from medicinal plant species such as curcumin. Low water solubility and poor bioavailability are recognized as two main disadvantages of curcumin, lipophilic phytopolyphenol, which could be controlled by targeted polymeric micro and nano-scaffolds. Consequently, this review has discussed the capacity and challenges of these types of formulations according to recent investigations.

Keywords

Antibacterial activity; wound healing; curcumin; micro/nano-scaffolds; biocompatible polymers

Alavi, M., Moetasam Zorab, M. ., Ashengroph, M. ., Aljelehawy, Q. H. A. ., & Kahrizi, D. (2022). Antibacterial and wound healing applications of curcumin in micro and nano-scaffolds based on chitosan, cellulose, and collagen: Antibacterial and wound healing applications of curcumin in micro and nano-scaffolds. Cellular and Molecular Biology, 68(3), 9–14. https://doi.org/10.14715/cmb/2022.68.3.2