Frontiers of Ferroptosis in Cancer Treatment

Durr-e-shahwar  Malik; Mirna Azalea  Romero; Saiyada Fatima Maida  Halim; Deena  Elsori; Lara  Youssef; Ishmuratova Margarita  Yulaevna; Uteuliyev Yerzhan  Sabitaliyevich; Rukset  Attar

doi:10.14715/cmb/2022.68.2.31

Issue

Vol. 68 No. 2: Issue 2

Issue Published : June 8, 2022

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Frontiers of Ferroptosis in Cancer Treatment

https://doi.org/10.14715/cmb/2022.68.2.31

Durr-e-shahwar Malik

Institute of Pharmaceutical Sciences, PUMHSW, Nawabshah, Pakistan

Mirna Azalea Romero

Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica, Av. Solidaridad S/N, Colonia Hornos Insurgentes, cp 39300, Acapulco, Guerrero México

Saiyada Fatima Maida Halim

Rashid Latif Medical College, Lahore, Pakistan

Deena Elsori

Faculty of Resilience, Rabdan Academy, Abu Dhabi, United Arab

Lara Youssef

Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand (UOB), Al-Kurah, Lebanon

Ishmuratova Margarita Yulaevna

E. A. Buketov Karaganda University, Kazakhstan

Uteuliyev Yerzhan Sabitaliyevich

Scientific Center for Innovative Technologies and Research, Kazakhstan

Rukset Attar

Department of Obstetrics and Gynecology, Yeditepe University, Turkey

Corresponding Author(s) : Rukset Attar

ruksetattar@hotmail.com

Cellular and Molecular Biology, Vol. 68 No. 2: Issue 2
Article Published : February 28, 2022

Abstract

Recent phenomenal advancements in genomic and proteomic technologies and rapid breakthroughs in the interpretation of large gene expression datasets have enabled scientists to comprehensively characterize the gene signatures involved in ferroptosis. Ferroptosis is an iron-dependent form of non-apoptotic cell death that has gained the worthwhile attention of both basic and clinical researchers. Ferroptosis has dichotomous, context-dependent functions both as a tumor suppressor and promoter of carcinogenesis. Essentially, pharmacological modulation of ferroptosis by its induction as well as its inhibition holds enormous potential to overcome drug resistance and to improve the therapeutic potential of chemotherapeutic drugs in a wide variety of cancers.

Malik, D.- e- shahwar ., Romero, M. A. ., Halim, S. F. M. ., Elsori, D. ., Youssef, L. ., Yulaevna, I. M. ., Sabitaliyevich, U. Y. ., & Attar, R. . (2022). Frontiers of Ferroptosis in Cancer Treatment. Cellular and Molecular Biology, 68(2), 213–226. https://doi.org/10.14715/cmb/2022.68.2.31