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6-Gingerol inhibits proliferation in gastric cancer via the STAT3 pathway in vitro
Corresponding Author(s) : Mian-Hua Wu
Cellular and Molecular Biology,
Vol. 65 No. 3: Issue 3
Abstract
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- Hassanipour-Azgomi S, Mohammadian-Hafshejani A, Ghoncheh M, Towhidi F, Jamehshorani S, Salehiniya H. Incidence and mortality of prostate cancer and their relationship with the Human Development Index worldwide. Prostate Int 2016; 4: 118-124.
- Sugano K. Screening of gastric cancer in Asia. Best Pract Res Clin Gastroenterol 2015; 29: 895-905.
- Sun Q, Lu NN, Feng L. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Biochem Biophys Res Commun 2018; 498: 164-170.
- Suzuki H, Oda I, Abe S, Sekiguchi M, Mori G, Nonaka S, et al. High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection. Gastric Cancer 2016; 19: 198-205.
- Lee J, Kang WK, Park JO, Park SH, Park YS, Lim HY, et al. Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. APMIS 2009; 117: 598-606.
- Lim HS, Kim OS, Kim BY, Jeong SJ. Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells. J Med Food 2016; 19: 1032-1040.
- Fathi N, Rashidi G, Khodadadi A, Shahi S, Sharifi S. STAT3 and apoptosis challenges in cancer. Int J Biol Macromol 2018; 117: 993-1001.
- Ghasemzadeh A, Jaafar H, Rahmat A. Variation of the Phytochemical Constituents and Antioxidant Activities of Zingiber officinale var. rubrum Theilade Associated with Different Drying Methods and Polyphenol Oxidase Activity. Molecules 2016; 21: 6.
- Krell J, Stebbing J. Ginger: the root of cancer therapy? Lancet Oncol 2012; 13: 235-236.
- Chen YL, Zhuang XD, Xu ZW, Lu LH, Guo HL, Wu WK, et al. Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway. Evid Based Complement Alternat Med 2013; 2013: 970490.
- Zhang F, Zhang JG, Yang W, Xu P, Xiao YL, Zhang HT. 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation. Biomed Pharmacother 2018; 107: 1523-1529.
- Haris P, Mary V, Sudarsanakumar C. Probing the interaction of the phytochemical 6-gingerol from the spice ginger with DNA. Int J Biol Macromol 2018; 113: 124-131.
- Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A 1997; 94: 3801-3810.
- Zhong Z, Wen Z, Darnell JE Jr. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A 1994; 91: 4806-4810.
- Danial NN, Pernis A, Rothman PB. Jak-STAT signaling induced by the v-abl oncogene. Science 1995; 269: 1875-1877.
- van Meerloo J, Kaspers GJ, Cloos J. Cell sensitivity assays : the MTT assay. Methods Mol Biol 2011; 731: 237-245.
- Sayre KR, Dodd RY, Tegtmeier G, Layug L, Alexander SS, Busch MP. False-positive human immunodeficiency virus type 1 western blot tests in noninfected blood donors. Transfusion 2010; 36: 45-52.
- Qiu P, Zhang S, Zhou Y, Zhu M, Kang Y, Chen D, et al. Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-κB activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy. Eur J Med Chem 2017; 139: 917-925.
- Xu Y, Wang Q, Feng Y, Caleb F, Zhu Y, Emmanuel OS, et al. Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation. J Funct Foods 2016; 27: 703-710.
- Zhang F, Zhang JG, Qu J, Zhang Q, Prasad C, Wei ZJ. Assessment of anti-cancerous potential of 6-gingerol ( Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells. Food Chem Toxicol 2017; 109: 910-922.
- Hoey I, Grusby MJ. STATs as Mediators of Cytokine-Induced Responses. Adv Immunol 1998: 145-162.
- Wu H, Huang M, Cao P, Wang T, Shu Y, Liu P. MiR-135a targetsJAK2and inhibits gastric cancer cell proliferation. Cancer Biol Ther 2014; 13: 281-288.
- Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, et al. Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer. Mol Cancer Ther 2011; 11: 277-287.
- Xiong H, Chen ZF, Liang QC, Du W, Chen HM, Su WY, et al. Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. J Cell Mol Med 2009; 13: 3668-3679.
- Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, et al. Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells. Cancer Res 2009; 69: 5876-5884.
- Kim SH, Ahn KS, Jeong SJ, Kwon TR, Jung JH, Yun SM, et al. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. Eur J Pharmacol 2011; 654: 10-16.
- Lai CS, Lee JH, Ho CT, Liu CB, Wang JM, Wang YJ, et al. Rosmanol Potently Inhibits Lipopolysaccharide-Induced iNOS and COX-2 Expression through Downregulating MAPK, NF-κB, STAT3 and C/EBP Signaling Pathways. J Agric Food Chem 2011; 3: 198-206.
References
Hassanipour-Azgomi S, Mohammadian-Hafshejani A, Ghoncheh M, Towhidi F, Jamehshorani S, Salehiniya H. Incidence and mortality of prostate cancer and their relationship with the Human Development Index worldwide. Prostate Int 2016; 4: 118-124.
Sugano K. Screening of gastric cancer in Asia. Best Pract Res Clin Gastroenterol 2015; 29: 895-905.
Sun Q, Lu NN, Feng L. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Biochem Biophys Res Commun 2018; 498: 164-170.
Suzuki H, Oda I, Abe S, Sekiguchi M, Mori G, Nonaka S, et al. High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection. Gastric Cancer 2016; 19: 198-205.
Lee J, Kang WK, Park JO, Park SH, Park YS, Lim HY, et al. Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. APMIS 2009; 117: 598-606.
Lim HS, Kim OS, Kim BY, Jeong SJ. Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells. J Med Food 2016; 19: 1032-1040.
Fathi N, Rashidi G, Khodadadi A, Shahi S, Sharifi S. STAT3 and apoptosis challenges in cancer. Int J Biol Macromol 2018; 117: 993-1001.
Ghasemzadeh A, Jaafar H, Rahmat A. Variation of the Phytochemical Constituents and Antioxidant Activities of Zingiber officinale var. rubrum Theilade Associated with Different Drying Methods and Polyphenol Oxidase Activity. Molecules 2016; 21: 6.
Krell J, Stebbing J. Ginger: the root of cancer therapy? Lancet Oncol 2012; 13: 235-236.
Chen YL, Zhuang XD, Xu ZW, Lu LH, Guo HL, Wu WK, et al. Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway. Evid Based Complement Alternat Med 2013; 2013: 970490.
Zhang F, Zhang JG, Yang W, Xu P, Xiao YL, Zhang HT. 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation. Biomed Pharmacother 2018; 107: 1523-1529.
Haris P, Mary V, Sudarsanakumar C. Probing the interaction of the phytochemical 6-gingerol from the spice ginger with DNA. Int J Biol Macromol 2018; 113: 124-131.
Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A 1997; 94: 3801-3810.
Zhong Z, Wen Z, Darnell JE Jr. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A 1994; 91: 4806-4810.
Danial NN, Pernis A, Rothman PB. Jak-STAT signaling induced by the v-abl oncogene. Science 1995; 269: 1875-1877.
van Meerloo J, Kaspers GJ, Cloos J. Cell sensitivity assays : the MTT assay. Methods Mol Biol 2011; 731: 237-245.
Sayre KR, Dodd RY, Tegtmeier G, Layug L, Alexander SS, Busch MP. False-positive human immunodeficiency virus type 1 western blot tests in noninfected blood donors. Transfusion 2010; 36: 45-52.
Qiu P, Zhang S, Zhou Y, Zhu M, Kang Y, Chen D, et al. Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-κB activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy. Eur J Med Chem 2017; 139: 917-925.
Xu Y, Wang Q, Feng Y, Caleb F, Zhu Y, Emmanuel OS, et al. Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation. J Funct Foods 2016; 27: 703-710.
Zhang F, Zhang JG, Qu J, Zhang Q, Prasad C, Wei ZJ. Assessment of anti-cancerous potential of 6-gingerol ( Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells. Food Chem Toxicol 2017; 109: 910-922.
Hoey I, Grusby MJ. STATs as Mediators of Cytokine-Induced Responses. Adv Immunol 1998: 145-162.
Wu H, Huang M, Cao P, Wang T, Shu Y, Liu P. MiR-135a targetsJAK2and inhibits gastric cancer cell proliferation. Cancer Biol Ther 2014; 13: 281-288.
Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, et al. Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer. Mol Cancer Ther 2011; 11: 277-287.
Xiong H, Chen ZF, Liang QC, Du W, Chen HM, Su WY, et al. Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. J Cell Mol Med 2009; 13: 3668-3679.
Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, et al. Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells. Cancer Res 2009; 69: 5876-5884.
Kim SH, Ahn KS, Jeong SJ, Kwon TR, Jung JH, Yun SM, et al. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. Eur J Pharmacol 2011; 654: 10-16.
Lai CS, Lee JH, Ho CT, Liu CB, Wang JM, Wang YJ, et al. Rosmanol Potently Inhibits Lipopolysaccharide-Induced iNOS and COX-2 Expression through Downregulating MAPK, NF-κB, STAT3 and C/EBP Signaling Pathways. J Agric Food Chem 2011; 3: 198-206.