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Vol. 64 No. 12: Issue 12

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Omentin Val/Val genotype increases predisposition to acne vulgaris without changing omentin serum level

https://doi.org/10.14715/cmb/2018.64.12.16
Hatice Soguktas
Department of Medical Biology and Genetics, Duzce University Institute of Health Science, Duzce, Turkey
Kursat Oguz Yaykasli
Department of Medical Genetics, Duzce, Duzce University Medical Faculty, Turkey
http://orcid.org/0000-0001-7550-6370
Hakan Turan
Department of Dermatology, Duzce University Medical Faculty, Duzce, Turkey
Ertugrul Kaya
Department of Pharmacology, Duzce University Medical Faculty, Duzce, Turkey
Emine Yaykasli
Department of Medical Biology and Genetics, Duzce University Institute of Health Science, Duzce, Turkey

Corresponding Author(s) : Kursat Oguz Yaykasli

kursatyay@yahoo.com

Cellular and Molecular Biology, Vol. 64 No. 12: Issue 12

Abstract

Acne vulgaris is the most frequent and multifactorial inflammatory skin disorder in all races. Obesity is considered to be a risk factor for acne due to its contribution to inflammation. The involvements of inflammatory (leptin and resistin) and anti-inflammatory (adiponectin) adipokines in the pathogenesis of acne were reported. Omentin resembles adiponectin in terms of having inhibitory effect on tumor necrosis factor-α (TNF-α) induced inflammation, a vital process in the acne formation. This study was designed to investigate the putative involvement of omentin in acne formation. The genotyping was performed by restriction fragment length polymorphism (RFLP) method. Serum omentin protein levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Serum omentin level was not significantly changed between groups. However, the decreased serum omentin level was observed as the mean value of BMI increased. The Asp/Asp, Val/Asp and Val/Val genotypes distributions for control and patient groups (19[17.4%], 22[20.2%], and 3[2.8%] respectively, vs. 31[28.4%], 25[22.9%], and 9[8.3%], respectively) were obtained. The Val/Val (mutant homozygote) genotype was found nearly 1.8 times more in the patient group (p=0.403, OR=1.839 (0.442-7.653)). This is the first time to clarify a linkage between anti-inflammatory omentin and acne vulgaris. Omentin Val109Asp polymorphism affects the overall function of the protein. In conclusion, omentin Val/Val (mutant homozygote) genotype increases predisposition to acne vulgaris by probably disrupting overall protein function of omentin.

Keywords

Omentin Acne vulgaris Inflammation Obesity Adipokines.
Soguktas, H., Yaykasli, K. O., Turan, H., Kaya, E., & Yaykasli, E. (2018). Omentin Val/Val genotype increases predisposition to acne vulgaris without changing omentin serum level. Cellular and Molecular Biology, 64(12), 81–86. https://doi.org/10.14715/cmb/2018.64.12.16
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