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  3. Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer
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Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer

Issue Published : May 19, 2018

Bacillus Calmette Guérin (BCG) activates lymphocyte to promote autophagy and apoptosis of gastric cancer MGC-803 cell

https://doi.org/10.14715/cmb/2018.64.6.3
Keyu Yao
School of Traditional Chinese Medicine /School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Wei Wang
Department of Laboratory, Foshan Fourth People's Hospital, Foshan 528000, China
Haicheng Li
Shenzhen Center for Chronic Disease Control, Shenzhen 518102, China
Jinfei Lin
Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, China
Weiguo Tan
Shenzhen Center for Chronic Disease Control, Shenzhen 518102, China
Yuhui Chen
Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, China
Lina Guo
Nutritional department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China
Dongzi Lin
Clinic laboratory of Dongguan Sixth People's Hospital, Guangzhou 523008, China
Tao Chen
Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, China
Jie Zhou
School of Traditional Chinese Medicine /School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Shuangqing Zhai
School of Traditional Chinese Medicine /School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Weiye Yu
Shenzhen Center for Chronic Disease Control, Shenzhen 518102, China

Corresponding Author(s) : Jie Zhou

zjet65@163.com

Cellular and Molecular Biology, Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer
Article Published : May 15, 2018

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Abstract

Bacillus Calmette Guérin (BCG) has a potential anti-tumor effect on gastric cancer. However, the mechanism is still unclear. In this study, we investigated the effect of BCG on gastric cancer cell line MGC-803 and studied the potential cooperation of BCG and lymphocyte in determining the final fate of cancer cells. After treatment with BCG, the cell viability was significantly inhibited in a dosage-dependent manner. Flow cytometry assay showed the apoptosis rates were significantly increased by BCG. Using western blot assay, results showed that BCG increased cleaved-caspase-3, LC-3BII and Atg-3. After cocultured with BCG and lymphocyte, the apoptosis rates, the levels of cleaved-caspase-3, and the protein levels of LC-3BII and Atg-3 were significantly increased compared with BCG or lymphocytes alone groups. ELISA detection found that BCG induced secretion of interferon gamma (IFNg) from lymphocytes. BCG with IFNg also increased levels of cleaved-caspase-3, LC-3BII and Atg-3. Taken together, BCG promotes lymphocyte immunocompetence to induce cell apoptosis and autophagy in MGC-803 cells, might through inducing release of IFNg from peripheral blood lymphocytes.

Keywords

Bacillus Calmette Guérin Lymphocyte IFNg Gastric cancer Autophagy.
Yao, K., Wang, W., Li, H., Lin, J., Tan, W., Chen, Y., Guo, L., Lin, D., Chen, T., Zhou, J., Zhai, S., & Yu, W. (2018). Bacillus Calmette Guérin (BCG) activates lymphocyte to promote autophagy and apoptosis of gastric cancer MGC-803 cell. Cellular and Molecular Biology, 64(6), 11–16. https://doi.org/10.14715/cmb/2018.64.6.3
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