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Vol. 64 No. 5: Issue 5

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Hematoprotective effect of boron on cyclophosphamide toxicity in rats

https://doi.org/10.14715/cmb/2018.64.5.10
Mustafa Cengiz
Department of Elementary Education, Faculty of Education, Siirt University, Siirt, Turkey

Corresponding Author(s) : Mustafa Cengiz

mustafacengizogu@gmail.com

Cellular and Molecular Biology, Vol. 64 No. 5: Issue 5

Abstract

The goal of this study was to determine the effects of  boric acid (B) as a boron source on blood cells and indirectly on bone marrow. Intraperitoneally (i.p.) administration of 200 mg / kg of cyclophosphamide (CP) resulted in reductions in the number of erythrocyte (20%), hemoglobin (20%), leukocytes (96%), thrombocytes (41%), and hematocrit (21%). The group given CP alone was killed 3 days after the CP administrated. For the group having CP+B (200 mg/kg i.p) treatment was started 3 days earlier than the CP administration and continued to the finish of the experiment (6 days). On day 4, the animals were weighed again, relative doses of CP were expected, and CP+B was administered together. On day 7, blood samples were collected under anesthesia. The results suggest that B could reduce CP -induced toxicity on blood cells and bone marrow in rats.

Keywords

Cyclophosphamide Boron Hematotoxicity Cytoprotectivity Rats.
Cengiz, M. (2018). Hematoprotective effect of boron on cyclophosphamide toxicity in rats. Cellular and Molecular Biology, 64(5), 62–65. https://doi.org/10.14715/cmb/2018.64.5.10
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References
  1. Ehrenfried JA, Ko T, hompson EA and Evers BM (1997) Cell cycle-mediated regulation of hepatic regeneration, Surgery, 122 (5): 927-935 p.
  2. Fairchild WV, Spencer CR, Solomon HD, and Gangai MP (1979) The Incidence of Bladder Cancer After Cyclophosphamide Therapy, Journal of Urology, 122: 163-164 p.
  3. Kayaalp SO (1989) Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, Feryal Matbaacılık, Ankara, Cilt:I, S: 973-993, Cilt: II, S: 1100-1107 p.
  4. Pool BL, Bos RP, Nıemeyer U, Theuws JLG, and Schmalhl D (1988) Invitro/invivoEffect of Mesna on the Genotoxicity and Toxicity of Cyclophosphamide A Study Aimed at Clarifyingtheult Mechanim of Mesna"Ÿs Anticarsinogenic Activity, Toxicology Letters, 41:49-56 p.
  5. Kalaycıoğlu ME, Lıchtın AE, Andrese SW, Tuason L, Bolwell BJ (1995) High-Dose Busulfan and Cyclophosphamide Followed by Autologous Bone Morrow Transplantation and/or Peripheral Blood Progenitor Cell Rescue for Metastatic Breast Cancer. American Journal of Clinical Oncolology, 18(6): 491-494 p.
  6. Kumar KB, Kuttan R (2004) Chemoprotective Activity of an Extract of Phyllanthus Amarus Against Cyclophosphamide-Induced Toxicity in Mice. Phytomedicine, 12: 494-500 p.
  7. Senthilkumar S, Devaki T, Manohar BM, Babu MS (2006) Effect of squalene on cyclophosphamide-induced toxicity. Clinica Chimitica Acta, 364(1-2): 335-42.
  8. Kawabata TT, Chapman MY, Kım DH, Stevens WD, and Holsapple MP (1990) Mechanism of in vitro Immunu suppression by Hepatocyte Generated Cyclophosphamid eMetabolites and 4-Hydroxi cyclophosphamide, Biochemical Pharmacology, 40(5): 927-935 p.
  9. Türkez H, Geyikoğlu F, Tatar A, Keleş S, Ozkan A (2007) Effects of some boron compounds on peripheral human blood. Z Natur forsch C.;62(11-12):889-96.
  10. Ince S, Keles H, Erdogan M, Hazman O, Kucukkurt I (2012) Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice. Drug Chem Toxicol. 35(3):285-92.
  11. Kumar KBH, Kuttan R (2005) Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice Phytomedicine 12:494–500.
  12. Liang J, Huang M, Duan W, Yu XQ, Zhou S (2007) Design of new oxazaphosphorine anticancer drugs. Curr Pharm Des 13:963–978.
  13. George KS, Rajesh R, Sunil Kumar S, Sulekha B, Balaram P (2008) A polyherbal ayurvedic drug”Indukantha Ghritham as an adjuvant to cancer chemotherapy via immunomodulation. Immunobiology 213:641–649.
  14. Ayhanci A, Yaman S, Appak S and Gunes S (2009) Hematoprotective effect of seleno-L-methionine on cyclophosphamide toxicity in rats. Drug and Chemical Toxicology, 32:4, 424-428.
  15. Fraiser LH, Kanekal S, Kehrer JP (1991) Cyclophosphamide toxicity: characterizing and avoiding the problem. Drugs 42:781–795.
  16. Schuurman HJ, Smith HT, Cozzi E (2005) Tolerability of cyclophosphamide and methotrexate induction immunosuppression in nonhuman primates. Toxicology 213:1–12.
  17. Moore FR, Urda GA, Krıshna G, and Theıss JC (1995) An invivo/invitro Method for Assessing Micronucleus and Chromosome Aberration Induction in Rat Bone Morrow and Spleen. 1. Studies with Cyclophosphamide. Mutation Research/Environmental Mutagenesis and Related Subjects, 335 (2): 191-199.
  18. Trasler JM, Hales BF, Robaire B (1987) A time-course study of chronic paternal cyclophosphamide treatment in rats: effects on pregnancy outcome and themalere productive and hematologic systems. Biology of Reproduction, 37(2):317-26.
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