Boric acid protects against cyclophosphamide-induced oxidative stress and renal damage in rats

Mustafa Cengiz

doi:10.14715/cmb/2018.64.12.3

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Vol. 64 No. 12: Issue 12

Issue Published : October 2, 2018

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Boric acid protects against cyclophosphamide-induced oxidative stress and renal damage in rats

https://doi.org/10.14715/cmb/2018.64.12.3

Mustafa Cengiz

Department of Elementary Education, Faculty of Education, Siirt University, Siirt, Turkey

Corresponding Author(s) : Mustafa Cengiz

mustafacengizogu@gmail.com

Cellular and Molecular Biology, Vol. 64 No. 12: Issue 12
Article Published : September 30, 2018

Abstract

The worldwide increase in the rate of cancer incidence also leads to a significant increase in the use of chemotherapeutic agents. Unfortunately, the optimal clinical usefulness of these agents is heavy restricted by a high incidence of several organ toxicity and as well reason oxidative stress and bring about changing in antioxidant status. Kidney toxicity is a side effect often encountered with cyclophosphamide (CPM) which is commonly used in most cancer chemotherapy. The present study aims on the assessment of the probable defensive efficacy of Boric acid (BA) against CPM-induced oxidative stress and renal damage in rats. Based upon our investigation results with oxidative stress markers and light microscopic findings, it can be concluded that BA significantly reduced CPM induced oxidative stress and renal damage. As far as we know, high dose (200 mg/kg) of BA are the first study on the prevention of kidney damage caused by CPM. It is thought that the renoprotective effects of BA may be due to an increase in the activity of the antioxidant protection system and also inhibition of lipid per oxidation.

Keywords

Boric acid Cyclophosphamide Renoprotective Lipid peroxidation Oxidative stress Nephrotoxicity.

Cengiz, M. (2018). Boric acid protects against cyclophosphamide-induced oxidative stress and renal damage in rats. Cellular and Molecular Biology, 64(12), 11–14. https://doi.org/10.14715/cmb/2018.64.12.3

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References

Choudhury D, Ahmed Z (2006). Drug-associated renal dysfunction and injury. Nat Clin Pract Neph. 2(2):80-91.
Joy J, Nair C (2008). Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract. J Can Res Ther. 4(3),111-5.
Said E, Elkashef WF, Abdelaziz RR (2016). Tranilast ameliorates cyclophosphamide-induced lung injury and nephrotoxicity. Can. J. Physiol. Pharmacol. 94 ,347–358.
Murray FJ (1998). A comparative review of the pharmacokinetics of boric acid in rodents and humans. Biol.Trace. Elem. Res. 66,331–341.
Hunt CD (1994). The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect. 35"‘43.
Cengiz M (2018). Hematoprotective effect of boron on cyclophosphamide toxicity in rats. Cellular and Molecular Biology. 62-65.
Goudarzia M, Khodayara MJ, Tabatabaeib SMTH, Ghaznavic HFI, Mehrzadi S (2017). Pretreatment with melatonin protects against cyclophosphamide-induced oxidative stress and renal damage in mice. Fundamental & Clinical Pharmacology. 625–635.
Ince S, Keles H, Erdogan M, Hazman O, Kucukkurt I (2012). Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice. Drug Chem. Toxicol. 35(3):285-92.
Stankiewicz A, Skrzydlewska E, Makiela M (2002). Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats. Drug Metab. Drug Interact. 19, 67–82.
Zarei M, Shivanandappa T (2016). Neuroprotective effect of Decalepis hamiltoni on cyclophosphamide-induced oxidative stress in the mouse brain. J. Basic Clin. Physiol. Pharmacol. 27, 341–348.
Que L, He L, Yu C et al. (2016). Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression. Toxicol. Lett. 262, 17–26.
Kern JC, Kehrer JP (2002). Acrolein-induced cell death: a caspase influenced decision between apoptosis and oncosis/necrosis. Chem. Biol. Interact. 139, 79–95.
Singh M, Kumar N, Shuaib M, Garg VK, Sharma A (2014). A review on renal protective agents for cyclophosphamide induced nephrotoxicity. World J. Pharm. Sci. 3, 737–747.
Abraham P, Isaac B (2011). The effects of oral glutamine on cyclophosphamide-induced nephrotoxicity in rats. Hum. Exp. Toxicolo. 30, 616–623.
Sinanoglu O, Yener AN, Ekici S, Midi A, Aksungar FB (2012). The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. Urolo. 80 1392.
Mansour DF, Salama AAA, Hegazy RR, Omara EA, Nada SA (2017) Whey protein isolate protects against cyclophosphamide-induced acute liver and kidney damage in rats. Journal of Applied Pharmaceutical Science Vol. 7 (06), pp. 111-120.
Koss LG, Lavin P (1970). Effects of a Single dose of cyclophosphamide on various organs in the rat. II. Response of urinary bladder epithelium according to strain and sex. J Natl Cancer Inst. 44(5),1195-200.
Sadeghi A, Kalantar M, Molavinia S, Houshmand G, Bahadoram M, Mahdi EM, Goudarzi M (2017). Ameliorative effects of hydroalcoholic extract of Lavandula officinalis L. on cyclophosphamide-induced nephrotoxicity in mice J Nephropathol. 6(4), 324-332.
Pawa S, Ali S (2006). Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem. Biol. Interact. 160, 89"‘98.
Nielsen FH (1991). Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. FASEB J. 5, 2661"‘2667.
Hunt CD (1996). Biochemical effects of physiological amounts of dietary boron. J. Trace Elem. Exp. Med. 9, 185–213.
Ince S, Kucukkurt I, Demirel HH et al. (2014) Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere 108:197–204.
Henderson K, Stella SL, Kobylewski S, Eckhert CD (2009). Receptor activated Ca(2+) release is inhibited by boric acid in prostate cancer cells. PLoS One 4(6): e6009.
Sogut I, Paltun SO, Tuncdemir M, Ersoz M, Hurdag C (2018) The antioxidant and antiapoptotic effect of boric acid on hepatoxicity in chronic alcohol-fed rats. Canadian Journal of Physiology and Pharmacology, 2018, Vol. 96, No. 4 : pp. 404-411.
Weir RJJ, Fisher RS (1972). Toxicologic studies on borax and boric acid. Toxicol Appl Pharmacol. 23, 351 364.
Coban FK, Ince S, Kucukkurt I, Demirel HH, Hazman O (2014). Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats. Drug Chem. Toxicol. 0148-0545.
Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G, Inal ME (2015). Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Exp. Ther. Med. 9(3), 1023-1027.

References

Choudhury D, Ahmed Z (2006). Drug-associated renal dysfunction and injury. Nat Clin Pract Neph. 2(2):80-91.

Joy J, Nair C (2008). Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract. J Can Res Ther. 4(3),111-5.

Said E, Elkashef WF, Abdelaziz RR (2016). Tranilast ameliorates cyclophosphamide-induced lung injury and nephrotoxicity. Can. J. Physiol. Pharmacol. 94 ,347–358.

Murray FJ (1998). A comparative review of the pharmacokinetics of boric acid in rodents and humans. Biol.Trace. Elem. Res. 66,331–341.

Hunt CD (1994). The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect. 35"‘43.

Cengiz M (2018). Hematoprotective effect of boron on cyclophosphamide toxicity in rats. Cellular and Molecular Biology. 62-65.

Goudarzia M, Khodayara MJ, Tabatabaeib SMTH, Ghaznavic HFI, Mehrzadi S (2017). Pretreatment with melatonin protects against cyclophosphamide-induced oxidative stress and renal damage in mice. Fundamental & Clinical Pharmacology. 625–635.

Ince S, Keles H, Erdogan M, Hazman O, Kucukkurt I (2012). Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice. Drug Chem. Toxicol. 35(3):285-92.

Stankiewicz A, Skrzydlewska E, Makiela M (2002). Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats. Drug Metab. Drug Interact. 19, 67–82.

Zarei M, Shivanandappa T (2016). Neuroprotective effect of Decalepis hamiltoni on cyclophosphamide-induced oxidative stress in the mouse brain. J. Basic Clin. Physiol. Pharmacol. 27, 341–348.

Que L, He L, Yu C et al. (2016). Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression. Toxicol. Lett. 262, 17–26.

Kern JC, Kehrer JP (2002). Acrolein-induced cell death: a caspase influenced decision between apoptosis and oncosis/necrosis. Chem. Biol. Interact. 139, 79–95.

Singh M, Kumar N, Shuaib M, Garg VK, Sharma A (2014). A review on renal protective agents for cyclophosphamide induced nephrotoxicity. World J. Pharm. Sci. 3, 737–747.

Abraham P, Isaac B (2011). The effects of oral glutamine on cyclophosphamide-induced nephrotoxicity in rats. Hum. Exp. Toxicolo. 30, 616–623.

Sinanoglu O, Yener AN, Ekici S, Midi A, Aksungar FB (2012). The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. Urolo. 80 1392.

Mansour DF, Salama AAA, Hegazy RR, Omara EA, Nada SA (2017) Whey protein isolate protects against cyclophosphamide-induced acute liver and kidney damage in rats. Journal of Applied Pharmaceutical Science Vol. 7 (06), pp. 111-120.

Koss LG, Lavin P (1970). Effects of a Single dose of cyclophosphamide on various organs in the rat. II. Response of urinary bladder epithelium according to strain and sex. J Natl Cancer Inst. 44(5),1195-200.

Sadeghi A, Kalantar M, Molavinia S, Houshmand G, Bahadoram M, Mahdi EM, Goudarzi M (2017). Ameliorative effects of hydroalcoholic extract of Lavandula officinalis L. on cyclophosphamide-induced nephrotoxicity in mice J Nephropathol. 6(4), 324-332.

Pawa S, Ali S (2006). Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem. Biol. Interact. 160, 89"‘98.

Nielsen FH (1991). Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. FASEB J. 5, 2661"‘2667.

Hunt CD (1996). Biochemical effects of physiological amounts of dietary boron. J. Trace Elem. Exp. Med. 9, 185–213.

Ince S, Kucukkurt I, Demirel HH et al. (2014) Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere 108:197–204.

Henderson K, Stella SL, Kobylewski S, Eckhert CD (2009). Receptor activated Ca(2+) release is inhibited by boric acid in prostate cancer cells. PLoS One 4(6): e6009.

Sogut I, Paltun SO, Tuncdemir M, Ersoz M, Hurdag C (2018) The antioxidant and antiapoptotic effect of boric acid on hepatoxicity in chronic alcohol-fed rats. Canadian Journal of Physiology and Pharmacology, 2018, Vol. 96, No. 4 : pp. 404-411.

Weir RJJ, Fisher RS (1972). Toxicologic studies on borax and boric acid. Toxicol Appl Pharmacol. 23, 351 364.

Coban FK, Ince S, Kucukkurt I, Demirel HH, Hazman O (2014). Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats. Drug Chem. Toxicol. 0148-0545.

Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G, Inal ME (2015). Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Exp. Ther. Med. 9(3), 1023-1027.

Author biographies is not available.