Contrast enhanced ultrasound in diagnosis of endometrial carcinoma and endometrial hyperplasia

Qichen Su; Zhen Sun; Guorong Lv

doi:10.14715/cmb/2018.64.11.16

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Vol. 64 No. 11: Issue 11

Issue Published : August 31, 2018

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Contrast enhanced ultrasound in diagnosis of endometrial carcinoma and endometrial hyperplasia

https://doi.org/10.14715/cmb/2018.64.11.16

Qichen Su

Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, China

Zhen Sun

Department of Clinical Medicine, Quanzhou Medical College, Quanzhou 362000, Fujian, China

Guorong Lv

Department of Clinical Medicine, Quanzhou Medical College, Quanzhou 362000, Fujian, China

Corresponding Author(s) : Guorong Lv

lvguorong_1@sohu.com

Cellular and Molecular Biology, Vol. 64 No. 11: Issue 11
Article Published : August 30, 2018

Abstract

The present study was aimed to compare application of contrast enhanced ultrasound (CEUS) in diagnosis of endometrial carcinoma (EC) and endometrial hyperplasia (EH). A total of 81 patients with EC and simple EH were selected in this study. Among all patients, 39 cases were diagnosed as EC and 42 cases were diagnosed with EH. All patients were diagnosed by CEUS examination. The diagnosis of EC and EH was also confirmed by endometrial biopsy. CEUS was conducted for all patients. Eendometrial thickness was measured and the mean arrival time, time-to-peak, enhancement time, arrival intensity, peak intensity, enhancement intensity, rising rate, washout half-time and clearance half-time were recorded. Myometrial invasion was categorized into 2 stages <50% and >50%. No significant difference was observed in clinical basis between the two groups. Endometrial thickness of EC was significantly higher than that of EH, P<0.05. Results of CEUS parameters showed that in EC patients, all values of arrival time, time-to-peak, washout half-time and clearance half-time were all shorter in EC group compared with those in EH patients, P<0.05. And values of peak intensity, enhancement intensity, and rising rate were also lower in EC patients than those in EH patients, P<0.05. Diagnostic accuracy of CEUS in myometrial invasion for EC was shown showed that 26 of 30 cases were diagnosed as myometrial invasion <50% by CEUS and 7 of 9 cases were diagnosed as myometrial invasion >50%. The total diagnostic accuracy of CEUS is 82.62% (33/39). We conducted a comparison study to analyze different diagnostic effects of CEUS for EC and EH. The study may give more clinical basic data in the field of CEUS application in diagnosis of EC and can give a reference to the difference between EC and EH.

Keywords

Contrast enhanced ultrasound Diagnosis Endometrial carcinoma Endometrial hyperplasia.

Su, Q., Sun, Z., & Lv, G. (2018). Contrast enhanced ultrasound in diagnosis of endometrial carcinoma and endometrial hyperplasia. Cellular and Molecular Biology, 64(11), 88–91. https://doi.org/10.14715/cmb/2018.64.11.16

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References

Maso L D, Augustin L S A, Karalis A, et al. Circulating Adiponectin and Endometrial Cancer Risk[J]. Journal of Clinical Endocrinology & Metabolism. 2013; 89(3):1160-1163.
Wright J D, Medel N I B, Sehouli J, et al. Contemporary management of endometrial cancer. Lancet. 2012; 379(9823):1352.
Colombo N, Creutzberg C, Amant F, et al. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Annals of Oncology. 2016; 26(1):1.
Siegel R L, Miller K D, Jemal A. Cancer statistics, 2015.. Ca A Cancer Journal for Clinicians. 2015; 63(1):11–30.
Kurosawa H, Ito K, Nikura H, et al. Hysteroscopic inspection and total curettage are insufficient for discriminating endometrial cancer from atypical endometrial hyperplasia. Tohoku Journal of Experimental Medicine. 2012; 228(4):365-70.
Crispi C P, Vanin C M, Dibi R P, et al. Postmenopausal Bleeding: Findings and Accuracy of Hysteroscopy and Histopathologic in the Diagnosis of Endometrial Cancer. Journal of Minimally Invasive Gynecology. 2011; 18(6):S83-S83.
Bakir B, Sanli S, Bakir V L, et al. Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening. Clinical Imaging. 2017; 41:86-94.
Bollineni V R, Ytrehauge S, Bollinenibalabay O, et al. High diagnostic value of FDG-PET/CT in endometrial cancer: Systematic review and meta-analysis of the literature. Journal of Nuclear Medicine. 2016; 12(1):38-48.
Jacobs I, Gentry-Maharaj A, Burnell M, et al. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. Lancet Oncology. 2011; 12(1):38-48.
de Boer S M, Nout R A, Jürgenliemkschulz I M, et al. Long-Term Impact of Endometrial Cancer Diagnosis and Treatment on Health-Related Quality of Life and Cancer Survivorship: Results From the Randomized PORTEC-2 Trial. International Journal of Radiation Oncology Biology Physics. 2015; 93(4):797-809.
Armstrong A J, Hurd W W, Elguero S, et al. Diagnosis and management of endometrial hyperplasia. Journal of Minimally Invasive Gynecology. 2012; 19(5):562-571.
Lencioni R, Piscaglia F, Bolondi L. Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma. La radiologia medica. 2015; 48(7):848-57.
Dietrich C F, Averkiou M A, Correas J M, et al. An EFSUMB introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for quantification of tumour perfusion. Ultraschall in Der Medizin. 2012; 33(4):344-51.
Wang J, Lv F, Fei X, et al. Study on the Characteristics of Contrast-Enhanced Ultrasound and Its Utility in Assessing the Microvessel Density in Ovarian Tumors or Tumor-Like Lesions. International Journal of Biological Sciences. 2011; 7(5):600-6.
Song Y, Yang J, Liu Z, et al. Preoperative evaluation of endometrial carcinoma by contrast-enhanced ultrasonography. Bjog An International Journal of Obstetrics & Gynaecology. 2009; 116(116):294-8.
Lencioni R, Piscaglia F, Bolondi L. Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma. La radiologia medica. 2015; 48(7):848-857.
Zhu X S, Gao Y H, Wang S S, et al. Contrast-enhanced ultrasound diagnosis of splenic artery steal syndrome after orthotopic liver transplantation. Liver Transplantation. 2012; 18(8):966.
Qiu L, Zhang X, Liu D, et al. Contrast-Enhanced Ultrasonography Diagnostic Evaluation of Esophageal Varices in Patients With Cirrhosis. Ultrasound Quarterly. 2015; 32(2).
Zhou X D, Ren X L, Zhang J, et al. Therapeutic response assessment of high intensity focused ultrasound therapy for uterine fibroid: utility of contrast-enhanced ultrasonography. European Journal of Radiology. 2007; 62(2):289-294.
Liu Y, Xu Y, Cheng W, et al. Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. Oncology Letters. 2016; 12(5):3763-3770.
Liu Z Z, Jiang Y X, Dai Q, et al. Imaging of endometrial carcinoma using contrast-enhanced sonography. Journal of Ultrasound in Medicine Official Journal of the American Institute of Ultrasound in Medicine. 2011; 30(11):1519-1527.

References

Maso L D, Augustin L S A, Karalis A, et al. Circulating Adiponectin and Endometrial Cancer Risk[J]. Journal of Clinical Endocrinology & Metabolism. 2013; 89(3):1160-1163.

Wright J D, Medel N I B, Sehouli J, et al. Contemporary management of endometrial cancer. Lancet. 2012; 379(9823):1352.

Colombo N, Creutzberg C, Amant F, et al. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Annals of Oncology. 2016; 26(1):1.

Siegel R L, Miller K D, Jemal A. Cancer statistics, 2015.. Ca A Cancer Journal for Clinicians. 2015; 63(1):11–30.

Kurosawa H, Ito K, Nikura H, et al. Hysteroscopic inspection and total curettage are insufficient for discriminating endometrial cancer from atypical endometrial hyperplasia. Tohoku Journal of Experimental Medicine. 2012; 228(4):365-70.

Crispi C P, Vanin C M, Dibi R P, et al. Postmenopausal Bleeding: Findings and Accuracy of Hysteroscopy and Histopathologic in the Diagnosis of Endometrial Cancer. Journal of Minimally Invasive Gynecology. 2011; 18(6):S83-S83.

Bakir B, Sanli S, Bakir V L, et al. Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening. Clinical Imaging. 2017; 41:86-94.

Bollineni V R, Ytrehauge S, Bollinenibalabay O, et al. High diagnostic value of FDG-PET/CT in endometrial cancer: Systematic review and meta-analysis of the literature. Journal of Nuclear Medicine. 2016; 12(1):38-48.

Jacobs I, Gentry-Maharaj A, Burnell M, et al. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. Lancet Oncology. 2011; 12(1):38-48.

de Boer S M, Nout R A, Jürgenliemkschulz I M, et al. Long-Term Impact of Endometrial Cancer Diagnosis and Treatment on Health-Related Quality of Life and Cancer Survivorship: Results From the Randomized PORTEC-2 Trial. International Journal of Radiation Oncology Biology Physics. 2015; 93(4):797-809.

Armstrong A J, Hurd W W, Elguero S, et al. Diagnosis and management of endometrial hyperplasia. Journal of Minimally Invasive Gynecology. 2012; 19(5):562-571.

Lencioni R, Piscaglia F, Bolondi L. Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma. La radiologia medica. 2015; 48(7):848-57.

Dietrich C F, Averkiou M A, Correas J M, et al. An EFSUMB introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for quantification of tumour perfusion. Ultraschall in Der Medizin. 2012; 33(4):344-51.

Wang J, Lv F, Fei X, et al. Study on the Characteristics of Contrast-Enhanced Ultrasound and Its Utility in Assessing the Microvessel Density in Ovarian Tumors or Tumor-Like Lesions. International Journal of Biological Sciences. 2011; 7(5):600-6.

Song Y, Yang J, Liu Z, et al. Preoperative evaluation of endometrial carcinoma by contrast-enhanced ultrasonography. Bjog An International Journal of Obstetrics & Gynaecology. 2009; 116(116):294-8.

Lencioni R, Piscaglia F, Bolondi L. Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma. La radiologia medica. 2015; 48(7):848-857.

Zhu X S, Gao Y H, Wang S S, et al. Contrast-enhanced ultrasound diagnosis of splenic artery steal syndrome after orthotopic liver transplantation. Liver Transplantation. 2012; 18(8):966.

Qiu L, Zhang X, Liu D, et al. Contrast-Enhanced Ultrasonography Diagnostic Evaluation of Esophageal Varices in Patients With Cirrhosis. Ultrasound Quarterly. 2015; 32(2).

Zhou X D, Ren X L, Zhang J, et al. Therapeutic response assessment of high intensity focused ultrasound therapy for uterine fibroid: utility of contrast-enhanced ultrasonography. European Journal of Radiology. 2007; 62(2):289-294.

Liu Y, Xu Y, Cheng W, et al. Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. Oncology Letters. 2016; 12(5):3763-3770.

Liu Z Z, Jiang Y X, Dai Q, et al. Imaging of endometrial carcinoma using contrast-enhanced sonography. Journal of Ultrasound in Medicine Official Journal of the American Institute of Ultrasound in Medicine. 2011; 30(11):1519-1527.

Author biographies is not available.