Issue

Vol. 63 No. 10: Issue 10

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Endothelial nitric oxide synthase 27VNTR (4b/4a) gene polymorphism and the risk of diabetic microvascular complications in Chinese populations

https://doi.org/10.14715/cmb/2017.63.10.8
X. Zhang
Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China
Z. Yang
Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China
X. Chen
Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China

Corresponding Author(s) : X. Chen

vq0056@163.com

Cellular and Molecular Biology, Vol. 63 No. 10: Issue 10

Abstract

To access the association of endothelial nitric oxide synthase (eNOS) gene 27VNTR (4b/4a) polymorphism with diabetic microvascular complications (DMI) susceptibility in Chinese populations. Data were retrieved in a systematic manner on PubMed database, ISI Web of Knowledge, the Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang, as well as manual searching of the references of the identified articles. Odds ratio (OR) and 95% confidence interval were used to evaluate the strength of associations. Potential sources of heterogeneity and publication bias were explored. Twelve published articles with thirteen outcomes including 1484 DMI patients and 1225 diabetic controls were included in the meta-analysis. The results showed no evidence for significant association of 27VNTR (4b/4a) polymorphism with DMI risk in dominant model (OR=1.36, 95% CI=0.90–2.06, P=0.15), and similar results were obtained in the allelic, additive and the recessive models (Pï¹¥0.05). Our meta-analysis suggests that eNOS gene 27VNTR (4b/4a) polymorphism might not be a risk factor for DMI in Chinese populations.

Keywords

Endothelial nitric oxide synthase Gene polymorphism Diabetic microvascular complications.
Zhang, X., Yang, Z., & Chen, X. (2017). Endothelial nitric oxide synthase 27VNTR (4b/4a) gene polymorphism and the risk of diabetic microvascular complications in Chinese populations. Cellular and Molecular Biology, 63(10), 54–58. https://doi.org/10.14715/cmb/2017.63.10.8
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. References
  2. Reusch JE. Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? J Clin Invest 2003; 112:986-8.
  3. Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wright AD, Turner RC, Holman RR. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. Bmj 2000; 321:412-9.
  4. Raman R, Gupta A, Krishna S, Kulothungan V, Sharma T. Prevalence and risk factors for diabetic microvascular complications in newly diagnosed type II diabetes mellitus. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS, report 27). J Diabetes Complications 2012; 26:123-8.
  5. Larsen T, Mose FH, Bech JN, Pedersen EB. Effect of nitric oxide inhibition on blood pressure and renal sodium handling: a dose-response study in healthy man. Clin Exp Hypertens 2012; 34:567-74.
  6. Li Q, Verma A, Han PY, Nakagawa T, Johnson RJ, Grant MB, Campbell-Thompson M, Jarajapu YP, Lei B, Hauswirth WW. Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci 2010; 51:5240-6.
  7. Nagareddy PR, McNeill JH, MacLeod KM. Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats. Eur J Pharmacol 2009; 611:53-9.
  8. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357:593-615.
  9. Farbstein D, Levy AP. The genetics of vascular complications in diabetes mellitus. Cardiol Clin 2010; 28:477-96.
  10. Dong JJ, Zhao JJ, Lee KO, Lir MC, Chan SW, Liao L. [Distribution of polymorphism in endothelial nitric oxide synthase gene in Singapore Chinese and its association with diabetic nephropathy]. Zhonghua Yi Xue Za Zhi 2007; 87:3415-7.
  11. Zhang Min LH, Yang Huiying, Wang Yuming, Song Dianping, Li Hong. Relationship of endothelial nitric oxide synthase ( eNOS) 4 a/ b gene polymorphism with diabetic nephropathy in T2DM. Chin J Diabetes 2005; 13:284-5.
  12. Xing Qian SB, Li Changchen, Du Jianling, Zhang Jianing, Xu Zhaohui. Association between endothelial nitric oxide synthase gene polymorphism and type 2 diabetic nephropathy. Chin J Endocrinol Metab 2004; 20:435-7.
  13. Sun Haiyan YM, Liu Shuqin, Wang Changjiang, Zhang Qiu, Chen Mingwei, Wang Yanhua, Sun Guihua. Study on the correlation of the polymorphism of Endothelial Nitric Oxide Synthase Gene with type 2 Diabetes Mellitus and Diabetic Nephropathy. Chin J Prev Contr Chron Non-commun Dis 2004; 12:101-3.
  14. Huang Huibin LL, Chen Mingqin. Relationship between eNOS gene polymophism and diabetic nephropathy. Chin J Nephro 2003; 19:181-2.
  15. Luo Hui NY. Association of polymorphism of endothelial nitric oxide synthase gene with diabetic nephropathy. Chinese Journal of Clinical Rehabilitation 2003; 7:1766-7.
  16. Lin S, Qu H, Qiu M. Allele A in intron 4 of ecNOS gene will not increase the risk of diabetic nephropathy in type 2 diabetes of Chinese population. Nephron 2002; 91:768.
  17. Li Changgui DZ, Lv Wenshan, Si Yuanguo, Liu Lin, Zhai Muxu. The association between polymorphism of endothelial nitric oxide synthase gene and diabetic nephropathy. Chin J Intern Med 2001; 40:729-32.
  18. Yue Mei YX, Dai Hong, Long Li. Diabetic retinopathy and variable number tandem repeat polymorphism in intron 4 of endothelial nitric oxide synthase gene. Chin J Ocul Fundus Dis 2011; 27:214-7.
  19. Zhang Min LH, Xu Yushan, Wang Yuming, Song Dianping, Li Hong. Endothe lial nitric ox ide synthase gene intron 4 polymorphism is associated with type 2 diabetic retinopathy. Chin J Endocrinol Metab 2005; 21:146-7.
  20. Sun Haiyan YM, Liu Shuqin, Wang Changjiang, Zhang Qiu, Chen Mingwei, Wang Yanhua, Sun Guihua. Association of endothelial nitric oxide synthase gene polymorphisms with type 2 diabetes mellitus and diabetic retinopathy. Chin J Endocrinol Metab 2004; 19:52-3.
  21. Wang XL, Mahaney MC, Sim AS, Wang J, Wang J, Blangero J, Almasy L, Badenhop RB, Wilcken DE. Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol 1997; 17:3147-53.
  22. Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab 2000; 70:241-51.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 876 Download : 298

Most read articles by the same author(s)