Issue

Vol. 63 No. 9: Issue 9

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Bioactive chemical compounds in Eremurus persicus (Joub. & Spach) Boiss. essential oil and their health implications

https://doi.org/10.14715/cmb/2017.63.9.1
B. Salehi
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran
S. A. Ayatollahi
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
A. Segura-Carretero
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda. Fuentenueva s/n, 18071 Granada, Spain
F. Kobarfard
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
M. d. M. Contreras
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda. Fuentenueva s/n, 18071 Granada, Spain
M. Faizi
Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
M. Sharifi-Rad
Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663-335, Iran
S. A. Tabatabai
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
J. Sharifi-Rad
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Corresponding Author(s) : J. Sharifi-Rad

javad.sharifirad@gmail.com

Cellular and Molecular Biology, Vol. 63 No. 9: Issue 9

Abstract

The genus Eremurus is native to Eastern Europe and temperate Asia. Particularly, Eremurus persicus (Joub. & Spach) Boiss. is highly valued in traditional foods and medicine. Scientific knowledge about E. persicus chemical composition and bioactivity is required. Therefore, the present study is aimed to determine the volatile composition of E. persicus essential oil (EO) by means of gas chromatography coupled to flame ionization/mass spectrometry detection. Moreover, the antioxidant, antimicrobial, anticancer, and acetylcholinesterase inhibitory activities of the EO were tested. Interestingly, the anti-dermatophyte potency was close to that of the drug griseofulvin, with minimum fungicidal concentration ranging between 0.7 and 4.5% depending on the fungi strain. The EO was also effective against hepatocellular carcinoma (Hep-G2) and breast adenocarcinoma (MCF-7) human cancer cell lines in a concentration (200-1500 ng/mL)-dependent manner, with a decrease of the cell viability up to 65% and 52%, respectively. The E. persicus EO was rich in terpenes and oxygenated terpene derivatives. Individually, limonene (16.25%), geranylgeraniol (15.23%), n-nonanal (9.48%), geranyl acetone (9.12%), benzene acetaldehyde (8.51%), linalool (7.93%), α-pinene (6.89%), and 1,8-cineol (5.22%) were the most abundant volatile compounds and could be chosen as analytical markers of this essential oil. In conclusion, our results suggested that this EO possesses a wide range of bioactive properties that could be useful in nutraceutical, functional foods and cosmeceutical formulations.

Keywords

Antimicrobial Antifungal Eremurus persicus Essential oil Natural antioxidant Terpenes.
Salehi, B., Ayatollahi, S. A., Segura-Carretero, A., Kobarfard, F., Contreras, M. d. M., Faizi, M., Sharifi-Rad, M., Tabatabai, S. A., & Sharifi-Rad, J. (2017). Bioactive chemical compounds in Eremurus persicus (Joub. & Spach) Boiss. essential oil and their health implications. Cellular and Molecular Biology, 63(9), 1–7. https://doi.org/10.14715/cmb/2017.63.9.1
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Sharifi-Rad J, Miri A, Hoseini-Alfatemi SM, Sharifi-Rad M, Setzer WN, Hadjiakhoondi A. Chemical Composition and Biological Activity of Pulicaria vulgaris Essential Oil from Iran. Natural Product Communications. 2014;9:1633-1636.
  2. Sahraie-Rad M, Izadyari A, Rakizadeh S. Sharifi-Rad J. Preparation of Strong Antidandruff Shampoo Using Medicinal Plant Extracts: A Clinical Trial and Chronic Dandruff Treatment. Jundishapur Journal of Natural Pharmaceutical Products. 2015;10:e21517.
  3. Sharifi-Rad M., Tayeboon GS, Miri A, Sharifi-Rad M, Setzer WN, Fallah F. et al. Mutagenic, antimutagenic, antioxidant, anti-lipoxygenase and antimicrobial activities of Scandix pecten-veneris L. Cellular and Molecular Biology. 2016;62(6):8-16.
  4. Bagheri G., Mirzaei M., Mehrabi R., J. Sharifi-Rad. Cytotoxic and Antioxidant Activities of Alstonia scholaris, Alstonia venenata and Moringa oleifera Plants from India. Jundishapur Journal of Natural Pharmaceutical Products. 2016;11(3):e31129.
  5. Sharifi-Rad M, Tayeboon GS, Sharifi-Rad J, Iriti M, Varoni EM, Razazi S. Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts. Cellular and Molecular Biology. 2016;62(6):80-85.
  6. Choudhary MI, Hussain A, Adhikari A, Bishnu P. Marasini, Samin A. Sattar, Wahab A, Hussain N, Ayatollahi SA, Rahman A. Anticancer and α-chymotrypsin inhibiting diterpenes and triterpenes from Salvia leriifolia. Phytochemistry Letters. 2013;6(1):139–143.
  7. Ayatollahi SA, Kobarfard F, Asgarpanah J, Ahmed Z. Chemical constituents from Otostegia persica. Journal of the Chemical Society of Pakistan. 2007;29(1):61-63.
  8. Mahboubi A, Kamalinejad M, Ayatollahi SA, Babaeian M. Total phenolic content and antibacterial activity of five plants of Labiatae against four foodborne and some other bacteria. Iranian Journal of Pharmaceutical Research. 2014;13(2): 559-566.
  9. Raeisi S, Sharifi-Rad M, Quek SY, Shabanpour B, Sharifi-Rad J. Evaluation of antioxidant and antimicrobial effects of shallot (Allium ascalonicum L.) fruit and ajwain (Trachyspermum ammi (L.) Sprague) seed extracts in semi-fried coated rainbow trout (Oncorhynchus mykiss) fillets for shelf-life extension. LWT-Food Science and Technology. 2016;65:112–121.
  10. Grondona E, Gatti G, López AG, Sánchez LR, Rivero V, Pessah O, Zunino MP, Ponce AA. Bio-efficacy of the Essential Oil of Oregano (Origanum vulgare Lamiaceae. ssp. hirtum). Plant Foods for Human Nutrition. 2014;69:351–357.
  11. Sharifi-Rad J, Sureda A, Tenore GC , Daglia M, Sharifi-Rad M, Valussi M, Tundis R, Sharifi-Rad M, Loizzo MR, Oluwaseun Ademiluyi A, Sharifi-Rad R, Ayatollahi SA, Iriti M. Biological activities of essential oils: From plant chemoecology to traditional healing systems. Molecules. 2017;22(1):70.
  12. Sharifi-Rad J, Mnayer D, Tabanelli G, Stojanović-Radić Z, Sharifi-Rad M, Yousaf Z, Vallone L, Setzer WN, Iriti M. Plants of the genus Allium as antibacterial agents: From tradition to pharmacy. Cellular and Molecular Biology. 2016;62:57-68.
  13. Sharifi-Rad J, Hoseini-Alfatemi SM, Sharifi-Rad M, Setzer WN. Chemical composition, antifungal and antibacterial activities of essential oil from Lallemantia royleana (Benth. In Wall.) Benth. Journal of Food Safety. 2015;35:19–25.
  14. Sharifi-Rad J, Hoseini-Alfatemi SM, Sharifi-Rad M, Sharifi-Rad M, Iriti M, Sharifi-Rad M, Sharifi-Rad R, Raeisi S. Phytochemical compositions and biological activities of essential oil from Xanthium strumarium L. Molecules. 2015;20:7034–7047.
  15. Andrade MA, das Graças Cardoso M, de Andrade J, Silva LF, Teixeira ML, Valério Resende JM, et al. Chemical Composition and antioxidant activity of essential oils from Cinnamodendron dinisii Schwacke and Siparuna guianensis Aublet. Antioxidants. 2013;2:384-397.
  16. Javad Sharifi-Rad, Dima Mnayer, Amir Roointan, Farkhondeh Shahri, Seyed Abdulmajid Ayatollahi. Marzieh Sharifi-Rad, Neda Molaee. Mehdi Sharifi-Rad. Antibacterial activities of essential oils from Iranian medicinal plants on extended-spectrum β-lactamase-producing Escherichia coli. Cellular and Molecular Biology, 62 (9): 75-82, 2016.
  17. Moradkhani S, Ayatollahi Abdulmajid, Ghanadian M, Moin MR, Razavizadeh M, Shahlaeif M. Phytochemical Analysis and Metal-chelation Activity of Achillea tenuifolia Lam. Iranian Journal of Pharmaceutical Research. 2012;11(1):177–183.
  18. Batooli H, Haguir Ebrahimabadi A, Nourouzi M, Mazoochi A. Essential oil composition in different parts of Eremurus persicus (Joub. & Spach) Boiss. From Azaran of Kashan. Eco-phytochemical Journal of Medical Plants. 2015;3:1-11.
  19. Kemenetsky R, Akhmetova M. Floral development of Eremurus altiacus (Liliaceae). Israel Journal of Plant Sciences. 1994;42:227-233.
  20. Wandelbo P. Liliaceae, 1-Asphodeloideae: Eremurus. In: Rechinger KH (ed) ‘Flora Iranica'. 1982; 151. Austria: Graz.
  21. Safar KN, Osaloo SK, Assadi M, Zarrei M, Mozaffar MK. Phylogenetic analysis of Eremurus, Asphodelus, and Asphodeline (Xanthorrhoeaceae-Asphodeloideae) inferred from plastid trnL-F and nrDNA ITS sequences. Biochemical Systematics and Ecology. 2014;56:32-39.
  22. Mosaddegh M, Naghibia F, Moazzenia H, Pirania A, Esmaeilia S. Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. Journal of Ethnopharmacology. 2012;141:80-95.
  23. Rajaei P, Mohamadi N. Ethnobotanical study of medicinal plants of Hezar mountain allocated in south east of Iran. Iranian Journal of Pharmaceutical Research. 2012;11: 1153-1167.
  24. Zare A, Arzani H, Javadi SA, Eslami MR, Meybodi NB. The economic value of paste (Eremurus persicus) in rangelands of Yazd case study: Rangelands of Khatam county. European Journal of Experimental Biology. 2014;4:583-587.
  25. Shahrokhi SR, Ghanimatdan M, Bazm MA, Karimi I. Survey of Indigenous medicinal plants and Traditional foods in the Lorestan province, West Iran. Bulletin of Environment, Pharmacology and Life Sciences. 2014;3:45-49.
  26. Hashemi SJ, Asgarpanah J, Alaee Z, Sadeghian S, Hasani H, Azimi A. In vitro antifungal activity of four medicinal plants used in Iranian Traditional Medicine. Research Journal of Pharmacognosy. 2014;1:39-43.
  27. Gaggeri R, Rossi D, Mahmood K, Gozzini D, Mannucci B, Corana F, et al. Towards elucidating Eremurus root remedy: Chemical profiling and preliminary biological investigations of Eremurus persicus and Eremurus spectabilis root ethanolic extracts. Journal of Medicinal Plants Research. 2015;8:1038-1048.
  28. Shibamoto T. Retention indices in essential oil analysis. In: Sandra P, Bicchi C, editors. Capillary Gas Chromatography in Essential Oil Analysis. New York: Huethig-Verlag. 1987.
  29. Rippon JW. Medical Mycology, third ed. W.B. Saunders Co, Philadelphia. 1988.
  30. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing, 20th Informational Supplement, CLSI document M100-S20. Wayne: CLSI. 2010.
  31. Norris HA, Elewski BE, Ghannoum MA. Optimal growth conditions for the determination of the antifungal susceptibility of three species of dermatophytes with the use of a microdilution method. Journal of the American Academy of Dermatology. 1999; 40:9-13.
  32. Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology.1961;7:88-95.
  33. Buckle J. Clinical aromatherapy, Essential oils in healthcare. St. Louis: Elsevier. 2015.
  34. Langeveld WT, Veldhuizen EJA, Burt SA. Synergy between essential oil components and antibiotics: a review. Critical Reviews in Microbiology. 2014;40:76–94
  35. Shin S. Lim S. Antifungal effects of herbal essential oils alone and in combination with ketoconazole against Trichophyton spp. Journal of Applied Microbiology, 2004;97:1289–1296.
  36. Inoue Y, Hada T, Shiraishi A, Hirose K, Hamashima H, Kobayashi S. Biphasic effects of geranylgeraniol, teprenone, and phytol on the growth of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 2005;49:1770–1774.
  37. Herman A, Tambor K, Herman A. Linalool affects the antimicrobial efficacy of essential oils. Current Microbiology. 2016;72:165–172.
  38. Morales-Soto A, Oruna-Concha MJ, Elmore JS, Barrajón-Catalán E, Micol V, Roldán C, Segura-Carretero A. Volatile profile of Spanish Cistus plants as sources of antimicrobials for industrial applications. Industrial Crops and Products. 2015;74: 425–433.
  39. Sharifi-Rad J, Sharifi-Rad M, Hoseini-Alfatemi SM, Iriti M, Sharifi-Rad M, Sharifi-Rad M. Composition, cytotoxic and antimicrobial activities of Satureja intermedia C.A.Mey essential oil. International Journal of Molecular Sciences. 2015;16:17812-17825.
  40. íœçüncü O, Cansu TB, í–zdemir T, Alpay Karaoğlu Åž, Yayli N. Chemical composition and antimicrobial activity of the essential oils of mosses (Tortula muralis Hedw., Homalothecium lutescens (Hedw.) H. Rob., Hypnum cupressiforme Hedw., and Pohlia nutans (Hedw.) Lindb.) from Turkey. Turkish Journal of Chemistry. 2010;34:825–834.
  41. Mothana RA, Al-Said MS, Al-Yahya MA, Al-Rehaily AJ, Khaled JM. GC and GC/MS analysis of essential oil composition of the endemic Soqotraen Leucas virgata Balf.f. and its antimicrobial and antioxidant activities. International Journal of Molecular Sciences. 2013;14:23129–23139.
  42. Paik S, Koh K-H, Beak S-M, Paek S-H, Kim J-A. The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. Biological and Pharmaceutical Bulletin. 2005; 28:802–807.
  43. Vieira Sobral M, Lira Xavier A, Cardoso Lima TD. de Sousa P. Antitumor activity of monoterpenes found in essential oils. The Scientific World Journal. 2014; 953451:1-35.
  44. Usta J, Kreydiyyeh S, Knio K, Barnabe P, Bou-Moughlabay Y, Dagher S. Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels. Chemico-Biological Interactions. 2009;180:39-46.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 1188 Download : 438