Analysis of potential interactions between vitamins D and C using gene expression profiles from mouse models

Yan Jiao; Mingming Niu; Cheng Tian; Jian Yan; Aron W. Vancil; Xuenan Yan; Ming Zhang

doi:10.14715/cmb/2017.63.11.13

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Vol. 63 No. 11: Issue 11

Issue Published : November 30, 2017

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Analysis of potential interactions between vitamins D and C using gene expression profiles from mouse models

https://doi.org/10.14715/cmb/2017.63.11.13

Yan Jiao

Mudanjiang Medical College, Mudanjiang, 157001, HeilongJiang, PR China

Mingming Niu

Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

Cheng Tian

Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

Jian Yan

Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

Aron W. Vancil

Department of Biology, Rhodes College, 2000 N. Parkway, Memphis, TN 38112, USA

Xuenan Yan

Department of Science, University of Tennessee, Knoxville, TN 37996, USA

Ming Zhang

Intergrative Research Center, The first hospital affilliated to Heilongjiang University of Traditional Chinese Medicine

Corresponding Author(s) : Ming Zhang

zyyzhangming@163.com

Cellular and Molecular Biology, Vol. 63 No. 11: Issue 11
Article Published : November 30, 2017

Abstract

Vitamin D (VD) and vitamin C (VC) have been recognized as essential elements for human health. Animal models, especially mouse models, have been widely used in the study of VD and VC. This study is to investigate how VD and VC interact at molecular level using whole genome expression profiles from spleens of 111 mouse strains and livers from 40 mouse strains. We first identified the genes that are closely correlated to vitamin D receptor (Vdr) and gulonolactone oxidase (Lgo). We next analyzed the potential molecular pathways of Vdrand Lgo correlated genes and examined how these two sets of pathways are connected in liver and spleen. Our results indicated that Vdrand Lgo associate to distinct groups of genes. While most of genes are not the same, a few of them are associated to both Vdrand Lgo. Our gene network construction suggests that there are interactions between Vdrand Lgopathways. Our work laid down the foundation for future study of the interactions between VD and VC and revealed the potential bias when using animals for the study of VD or VC, as humans do not produce VC.

Keywords

Gene Expression Mouse Network Vitamin C Vitamin D.

Jiao, Y., Niu, M., Tian, C., Yan, J., Vancil, A. W., Yan, X., & Zhang, M. (2017). Analysis of potential interactions between vitamins D and C using gene expression profiles from mouse models. Cellular and Molecular Biology, 63(11), 68–74. https://doi.org/10.14715/cmb/2017.63.11.13

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References

V. Reinhold, BF. Heike, J B. Barbara, et al. The urgent need to recommend an intake of vitamin D that is effective American Journal of Clinical Nutrition,; 85 (2007),pp. 649-50.
MF.Holick Vitamin D and bone health. Nutr. , 126(1996), pp. 1159S-64S.
JS. Adams, M. Hewison, Hewison Update in Vitamin D Journal of Clinical, 95 (2010), pp. 471–8.
MF. Holick Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease American Journal of Clinical Nutrition, 80 (2004), pp.1678S–88S.
G. Bánhegyi, J. Mándl The hepatic glycogenoreticular system Pathol. Oncol. Res., 7 (2001), pp. 107-10.
VR. Preedy, RR. Watson, Z. Sherma Dietary Components and Immune Function (Nutrition and Health) NJ: Humana Press, 2010. pp. 36-52.
N. Boyera , I. Galey , BA. Bernard Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International Journal of Cosmetic Science, 20(1998), pp. 151-8.
Y. Chen , CP. Curran , DW. Nebert , et al. Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice Genes, Brain and Behavior,11 (2012), pp. 269-77.
J. Welsh Vitamin D and breast cancer: insights from animal models. The American Journal of Clinical Nutrition, 80(2004), pp. 1721S-4S
AW. Norman The avian as an animal model for the study of the vitamin D endocrine system The Journal of Experimental Zoology, 4(1990), pp. 37-45.
FE. Nashold, CD. Nelson , LM. Brown , et al. One calcitriol dose transiently increases Helios+ FoxP3+ T cells and ameliorates autoimmune demyelinating disease Journal of Neuroimmunology, 263(2013), pp. 64-74
G. Perrone , T. Hideshima, H. Ikeda , et al. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia, 23(2009), pp. 1679-86
P. Gao, H. Zhang , R. Dinavahi , et al. HIF-dependent anti-tumorigenic effect of antioxidants in vivo Cancer Cell, 12(2007), pp. 230-8
L. Hasan , P. Vogeli, P. Stoll, et al. Neuenschwander S. Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs.
Mamm Genome. 15 (2004), pp. 323–33
J. Cui, YH. Pan, Y. Zhang, et al. Progressive pseudogenization: vitamin C synthesis and its loss in bats Mol Biol Evol, 28(2011), pp.1025–31.
H A. Montel, S. Kinet, N. Manel, et al. Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C. Cell, 132(2008), pp. 1039–48.
S. Telang, AL. Clem, JW. Eaton, et al. Depletion of ascorbic acid restricts angiogenesis and retards tumor growth in a mouse model Neoplasia, 9(2007), pp. 47–56.
KK. Parsons, N. Maeda, M. Yamauchi, et al. Ascorbic acid-independent synthesis of collagen in mice Am J Physiol Endocrinol Metab, 290(2006), pp. 1131–9
FE. Harrison, SS. Yu, DB KL. Van, et al. Elevated oxidative stress and sensorimotor deï¬cits but normal cognition in mice that cannot synthesize ascorbic acid. Neurochem, 106(2008), pp. 1198–208
R. Yu, HE. Schellhorn Recent applications of engineered animal antioxidant deficiency models in human nutrition and chronic disease J Nutr., 143( 2013), pp. 1-11.
QP. Li, X. Qi, R. Pramanik , et al. Dissects the Stress-induced c-Jun-dependent Vitamin D J. Biol. Chem, 282(2007), pp. 1544-1551.
S. Nagpal, S. Na, Rathnachalam Noncalcemic actions of vitamin D receptor ligands R Endocr Rev., 26(2005), pp. 662-87
X. Qing, YH. Qiu, WK. Gu PGMapper: a web-based tool linking phenotype to genes
Bioinformatics, 24 (2008), pp. 1011-1013
S. Cao, JK. Iyer, V. Lin Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein Biochem Biophys Res Commun, 345(2006), pp. 310-7
X. Wang, S. Bo, H. Lee, et al. Impaired Balance of Mitochondria Fission and Fusion in Alzheimer Disease. J Neurosci. , 29 (2009), pp. 9090–103
DJ. Jung, SY. Na, DS. Na, et al. Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors J Biol Chem. , 277(2002), pp. 1229-34J
DH. Dowhan, EP. Hong, D. Auboeuf, et al. Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta Mol Cell. , 17(2005), pp. 429-39
C. Jin, P. Ding, Y. Wang, et al. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8 FEBS Lett. , 579(2005), pp. 6375-82
C. Jin, Y. Wang, W. Han CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway J Cell Physiol., 211(2007), pp. 112-20
U. Dougherty, R. Mustafi, F. Sadiq, et al. The Renin-Angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer Clin Cancer Res., 20(2014), pp. 5848-59

References

V. Reinhold, BF. Heike, J B. Barbara, et al. The urgent need to recommend an intake of vitamin D that is effective American Journal of Clinical Nutrition,; 85 (2007),pp. 649-50.

MF.Holick Vitamin D and bone health. Nutr. , 126(1996), pp. 1159S-64S.

JS. Adams, M. Hewison, Hewison Update in Vitamin D Journal of Clinical, 95 (2010), pp. 471–8.

MF. Holick Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease American Journal of Clinical Nutrition, 80 (2004), pp.1678S–88S.

G. Bánhegyi, J. Mándl The hepatic glycogenoreticular system Pathol. Oncol. Res., 7 (2001), pp. 107-10.

VR. Preedy, RR. Watson, Z. Sherma Dietary Components and Immune Function (Nutrition and Health) NJ: Humana Press, 2010. pp. 36-52.

N. Boyera , I. Galey , BA. Bernard Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International Journal of Cosmetic Science, 20(1998), pp. 151-8.

Y. Chen , CP. Curran , DW. Nebert , et al. Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice Genes, Brain and Behavior,11 (2012), pp. 269-77.

J. Welsh Vitamin D and breast cancer: insights from animal models. The American Journal of Clinical Nutrition, 80(2004), pp. 1721S-4S

AW. Norman The avian as an animal model for the study of the vitamin D endocrine system The Journal of Experimental Zoology, 4(1990), pp. 37-45.

FE. Nashold, CD. Nelson , LM. Brown , et al. One calcitriol dose transiently increases Helios+ FoxP3+ T cells and ameliorates autoimmune demyelinating disease Journal of Neuroimmunology, 263(2013), pp. 64-74

G. Perrone , T. Hideshima, H. Ikeda , et al. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia, 23(2009), pp. 1679-86

P. Gao, H. Zhang , R. Dinavahi , et al. HIF-dependent anti-tumorigenic effect of antioxidants in vivo Cancer Cell, 12(2007), pp. 230-8

L. Hasan , P. Vogeli, P. Stoll, et al. Neuenschwander S. Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs.

Mamm Genome. 15 (2004), pp. 323–33

J. Cui, YH. Pan, Y. Zhang, et al. Progressive pseudogenization: vitamin C synthesis and its loss in bats Mol Biol Evol, 28(2011), pp.1025–31.

H A. Montel, S. Kinet, N. Manel, et al. Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C. Cell, 132(2008), pp. 1039–48.

S. Telang, AL. Clem, JW. Eaton, et al. Depletion of ascorbic acid restricts angiogenesis and retards tumor growth in a mouse model Neoplasia, 9(2007), pp. 47–56.

KK. Parsons, N. Maeda, M. Yamauchi, et al. Ascorbic acid-independent synthesis of collagen in mice Am J Physiol Endocrinol Metab, 290(2006), pp. 1131–9

FE. Harrison, SS. Yu, DB KL. Van, et al. Elevated oxidative stress and sensorimotor deï¬cits but normal cognition in mice that cannot synthesize ascorbic acid. Neurochem, 106(2008), pp. 1198–208

R. Yu, HE. Schellhorn Recent applications of engineered animal antioxidant deficiency models in human nutrition and chronic disease J Nutr., 143( 2013), pp. 1-11.

QP. Li, X. Qi, R. Pramanik , et al. Dissects the Stress-induced c-Jun-dependent Vitamin D J. Biol. Chem, 282(2007), pp. 1544-1551.

S. Nagpal, S. Na, Rathnachalam Noncalcemic actions of vitamin D receptor ligands R Endocr Rev., 26(2005), pp. 662-87

X. Qing, YH. Qiu, WK. Gu PGMapper: a web-based tool linking phenotype to genes

Bioinformatics, 24 (2008), pp. 1011-1013

S. Cao, JK. Iyer, V. Lin Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein Biochem Biophys Res Commun, 345(2006), pp. 310-7

X. Wang, S. Bo, H. Lee, et al. Impaired Balance of Mitochondria Fission and Fusion in Alzheimer Disease. J Neurosci. , 29 (2009), pp. 9090–103

DJ. Jung, SY. Na, DS. Na, et al. Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors J Biol Chem. , 277(2002), pp. 1229-34J

DH. Dowhan, EP. Hong, D. Auboeuf, et al. Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta Mol Cell. , 17(2005), pp. 429-39

C. Jin, P. Ding, Y. Wang, et al. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8 FEBS Lett. , 579(2005), pp. 6375-82

C. Jin, Y. Wang, W. Han CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway J Cell Physiol., 211(2007), pp. 112-20

U. Dougherty, R. Mustafi, F. Sadiq, et al. The Renin-Angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer Clin Cancer Res., 20(2014), pp. 5848-59

Author biographies is not available.