miR-146a rs2910164 polymorphism might be associated with coronary artery disease risk in Asians

H-Y. Zhou; Q. Wei; X-D Shi; H-Y. Cao; L. Qin

doi:10.14715/cmb/2017.63.8.6

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Vol. 63 No. 8: Issue 8

Issue Published : September 4, 2017

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miR-146a rs2910164 polymorphism might be associated with coronary artery disease risk in Asians

https://doi.org/10.14715/cmb/2017.63.8.6

H-Y. Zhou

Department of Cardiology, The First Hospital of Jilin University, No.71 of Xinmin Street, Changchun 130021, Jilin, China

Q. Wei

Department of Cardiology, The First Hospital of Jilin University, No.71 of Xinmin Street, Changchun 130021, Jilin, China

X-D Shi

Department of Hepatology, The First Hospital of Jilin University, No.71 of Xinmin Street, Changchun 130021, Jilin, China

H-Y. Cao

Department of Cardiology, The First Hospital of Jilin University, No.71 of Xinmin Street, Changchun 130021, Jilin, China

L. Qin

Department of Cardiology, The First Hospital of Jilin University, No.71 of Xinmin Street, Changchun 130021, Jilin, China

Corresponding Author(s) : L. Qin

jiezong66jie@163.com

Cellular and Molecular Biology, Vol. 63 No. 8: Issue 8
Article Published : August 30, 2017

Abstract

Recently, several studies reported the association between miR-146a rs2910164 polymorphism and coronary artery disease (CAD) risk. However, the results were inconclusive. We therefore did a meta-analysis to investigate this association. Electronic databases, including PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) databases, were searched. The strength of association was assessed by calculating odds ratios (OR) and 95% confidence interval (CI). Five eligible studies included in this meta-analysis. The total sample size of this meta-analysis was 1565 cases and 1541 controls. We found that miR-146a rs2910164 polymorphism was significantly associated with an increased CAD risk (OR = 1.19; 95% CI 1.07 – 1.32; P = 0.002). In the subgroup analysis by race, miR-146a rs2910164 polymorphism was significantly associated with an increased CAD risk in Asians (OR = 1.18; 95% CI 1.04 – 1.33; P = 0.008). However, we did not find significant result in Caucasians (OR = 1.22; 95% CI 0.86 – 1.74; P = 0.25). In the subgroup analysis by age, we found that miR-146a rs2910164 polymorphism increased CAD risk in old population (OR = 1.22; 95% CI 1.09 – 1.38; P = 0.0008). In conclusion, this meta-analysis found that miR-146a rs2910164 polymorphism was significantly associated with CAD risk.

Keywords

Coronary artery disease MicroRNA Polymorphism.

Zhou, H.-Y., Wei, Q., Shi, X.-D., Cao, H.-Y., & Qin, L. (2017). miR-146a rs2910164 polymorphism might be associated with coronary artery disease risk in Asians. Cellular and Molecular Biology, 63(8), 27–29. https://doi.org/10.14715/cmb/2017.63.8.6

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References

He J, Gu D, Wu X, Reynolds K, Duan X, Yao C, Wang J, Chen CS, Chen J, Wildman RP, Klag MJ, Whelton PK. Major causes of death among men and women in China. N Engl J Med. 2005;353:1124-34.
Usman A, Ribatti D, Sadat U, Gillard JH. From Lipid Retention to Immune-Mediate Inflammation and Associated Angiogenesis in the Pathogenesis of Atherosclerosis. J Atheroscler Thromb. 2015;22:739-49.
He X, Tang R, Sun Y, Wang YG, Zhen KY, Zhang DM, Pan WQ. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. EBioMedicine. 2016;13:339-347.
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Xiong XD, Cho M, Cai XP, Cheng J, Jing X, Cen JM, Liu X, Yang XL, Suh Y. A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression. Mutat Res. 2014; 761:15-20.
Bastami M, Ghaderian SM, Omrani MD, Mirfakhraie R, Vakili H, Parsa SA, Nariman-Saleh-Fam Z, Masotti A. MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. Genet Test Mol Biomarkers. 2016;20:241-8.
Wang J, Yan Y, Song D, Liu B. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. Biomed Res Int. 2016;2016:4285942.
Alipoor B, Meshkani R, Ghaedi H, Sharifi Z, Panahi G, Golmohammadi T. Association of miR-146a rs2910164 and miR-149 rs2292832 Variants with Susceptibility to Type 2 Diabetes. Clin Lab. 2016;62:1553-1561.
Yin Z, Cui Z, Ren Y, Xia L, Li H, Zhou B. MiR-146a polymorphism correlates with lung cancer risk in Chinese nonsmoking females. Oncotarget. 2017;8:2275-2283.
Bogunia-Kubik K, WysoczaÅ„ska B, Pić…tek D, Iwaszko M, Ciechomska M, Åšwierkot J. Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis. Arch Immunol Ther Exp (Warsz). 2017. doi: 10.1007/s00005-016-0443-5. [Epub ahead of print]

References

He J, Gu D, Wu X, Reynolds K, Duan X, Yao C, Wang J, Chen CS, Chen J, Wildman RP, Klag MJ, Whelton PK. Major causes of death among men and women in China. N Engl J Med. 2005;353:1124-34.

Usman A, Ribatti D, Sadat U, Gillard JH. From Lipid Retention to Immune-Mediate Inflammation and Associated Angiogenesis in the Pathogenesis of Atherosclerosis. J Atheroscler Thromb. 2015;22:739-49.

He X, Tang R, Sun Y, Wang YG, Zhen KY, Zhang DM, Pan WQ. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. EBioMedicine. 2016;13:339-347.

Czajka AA, Wójcicka A, Kubiak A, Kotlarek M, BakuÅ‚a-Zalewska E, Koperski Å, Wiechno W, JaÅ¼dÅ¼ewski K. Family of microRNA-146 Regulates RARÎ² in Papillary Thyroid Carcinoma. PLoS One. 2016;11:e0151968.

Shi L, Xu Z, Wu G, Chen X, Huang Y, Wang Y, Jiang W, Ke B. Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J. BMC Cancer. 2017;17:138.

Hamann L, Glaeser C, Schulz S, Gross M, Franke A, Nöthlings U, Schumann RR. A micro RNA-146a polymorphism is associated with coronary restenosis. Int J Immunogenet. 2014;41:393-6.

Chen L, Wu YT. Association of genetic polymorphisms in microRNAs precursor with the riskand prognosis of coronary heart diseases. J. Xi'an Jiaotong Univ. 2013, 34, 495–499.

Ramkaran P, Khan S, Phulukdaree A, Moodley D, Chuturgoon AA. miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease. Cell Biochem Biophys. 2014;68:259-66.

Xiong XD, Cho M, Cai XP, Cheng J, Jing X, Cen JM, Liu X, Yang XL, Suh Y. A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression. Mutat Res. 2014; 761:15-20.

Bastami M, Ghaderian SM, Omrani MD, Mirfakhraie R, Vakili H, Parsa SA, Nariman-Saleh-Fam Z, Masotti A. MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. Genet Test Mol Biomarkers. 2016;20:241-8.

Wang J, Yan Y, Song D, Liu B. Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. Biomed Res Int. 2016;2016:4285942.

Alipoor B, Meshkani R, Ghaedi H, Sharifi Z, Panahi G, Golmohammadi T. Association of miR-146a rs2910164 and miR-149 rs2292832 Variants with Susceptibility to Type 2 Diabetes. Clin Lab. 2016;62:1553-1561.

Yin Z, Cui Z, Ren Y, Xia L, Li H, Zhou B. MiR-146a polymorphism correlates with lung cancer risk in Chinese nonsmoking females. Oncotarget. 2017;8:2275-2283.

Bogunia-Kubik K, WysoczaÅ„ska B, Pić…tek D, Iwaszko M, Ciechomska M, Åšwierkot J. Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis. Arch Immunol Ther Exp (Warsz). 2017. doi: 10.1007/s00005-016-0443-5. [Epub ahead of print]

Author biographies is not available.