The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Nitrite/nitrate and malondialdehyde levels in nasal polyp
Corresponding Author(s) : G. Bugdayci
bugdayci_g@ibu.edu.tr
Cellular and Molecular Biology,
Vol. 54 No. 2: General Papers
Abstract
The aim of this study was to examine the pathophysiological role of NO (nitric oxide) and MDA (malondialdehyde) in tissue in patients with nasal polyposis. We measured nitrite/nitrate (Nitrite/Nitrate; NO2-/NO3-) and MDA in tissue and plasma of NP patients (n=20) and controls (n=20). MDA level expressed as the concentration of substances reacting to thiobarbituric acid and production of NO (concentration of nitrite/nitrate in plasma) by the Griess reaction were determined. The level of NO2- and NO3- in tissue are higher than that of the normal tissue (p<0.05). The level of MDA in tissue are higher than that of the normal tissue (p<0.05). The level of NO2- and NO3- in plasma of two groups are similar (p>0.05). The level of MDA in plasma is higher than that in the normal controls (p<0.05). The change in NO2-/NO3- and MDA levels of nasal polyp patients was demonstrated. Further studies are required concerning the significance of changes in lipid peroxidation and nitrite levels in pathogenesis of nasal polyp.
Keywords
Inflammation
Oxidative stress
Malondialdehyde
Nitric oxide
Nasal Polyposis.
Bugdayci, G., & Kaymakci, M. (2008). Nitrite/nitrate and malondialdehyde levels in nasal polyp. Cellular and Molecular Biology, 54(2), 1043–45. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/1026
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX