Effects of marine n-3 fatty acids on circulating levels of soluble adhesion molecules in patients with chronic heart failure
Corresponding Author(s) : O. Eschen
Cellular and Molecular Biology,
Vol. 56 No. 1: Omega-3 fatty acids and coronary heart disease
Inflammatory markers as circulating soluble cellular adhesion molecules (sCAMs) and high sensitive C-reactive protein (hsCRP) are elevated in patients with chronic heart failure (CHF), and may constitute an increased risk of adverse outcome. Marine n-3 polyunsaturated fatty acids (n-3 PUFA) may have anti-inflammatory effect and reduce levels of sCAMs (soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), P-selectin) and hsCRP. In a randomized, controlled trial, 138 patients with NYHA class II-III CHF were allocated to receive a daily supplement of 0.9 g of n-3 PUFA or olive-oil for 24 weeks. After supplementation, no significant changes occurred in sCAMs or hsCRP after adjusting for possible confounders. However, a significant reduction was observed in sP-selectin in patients receiving n-3 PUFA, but this result was only of borderline significance in a between- group analysis. In conclusion, a daily supplement with 0.9 g of n-3 PUFA does not significantly affect plasma levels of sCAMs or hs-CRP in patients with CHF. n-3 PUFA may reduce sP-selectin, indicating a possible effect on platelet (and endothelial) activation. The results also indicate that the low dose of n-3 PUFA used in many intervention trials does not have deleterious effects on sCAMs or hsCRP.
Heart Failure n-3 PUFA P-selectin ICAM-1 VCAM-1 C-reactive protein.
Eschen, O., Christensen, J. H., La rovere, M. T., Romano, P., Sala, P., & Schmidt, E. B. (2010). Effects of marine n-3 fatty acids on circulating levels of soluble adhesion molecules in patients with chronic heart failure. Cellular and Molecular Biology, 56(1), 45–51. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/1008
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