Issue
Copyright (c) 2025 Mohammad Salman Akhtar, Raed A. Alharbi, Arshi Talat, Abdulmajeed AA Sindi, Mohammad A. Shanawaz, Ali A Zaeri, Abdulbaset M Kabli, Abdulmohsen M Alruwetei, Dina K. Marghani
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Allele frequency of CTLA-4 rs231775 (+49 A>G) gene polymorphism and its association with cancer susceptibility in the Saudi Arabian population and other ethnic groups
Corresponding Author(s) : Mohammad Salman Akhtar
Cellular and Molecular Biology,
Vol. 71 No. 11: Issue 11
Abstract
Single-nucleotide polymorphisms (SNPs) of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene found in exon 1 are directly associated with the progression and onset of autoimmune disease and various human cancers. These SNPs are commonly known prognostic biomarkers for the prediction and early onset of cancer risk. The variant frequency of CTLA-4 rs231775 (+49 A>G) polymorphisms may affect the various ethnic groups differently. This study assessed the allelic frequency distribution of rs231775 (+49 A>G) polymorphisms in the Saudi Arabian population and compared it with other world populations. The data were extracted from case-control studies in several ethnic groups using PubMed (Medline) and similar web databases. The frequency of CTLA-4 rs231775 (+49 A>G) variant allele (G) was observed at 33.0% and different frequencies were found significant for Pakistan (p=0.02), China (p=0.05), China (p= 0.00), Iran (p=0.00), Poland (p=0.00), the USA (p=0.00) and Turkey (p=0.02) when the prevalence of Saudi Arabian population is compared to that of other populations. The observed finding reveals a distinct pattern of CTLA-4 rs231775 (+49 A>G) polymorphism variant allele in the populations of Saudi Arabia, maybe because of the differences in ethnicity. The observed findings can help assess the risk for the population harboring the risk allele of the rs231775 (+49 A>G) SNP and their subsequent susceptibility to cancer.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
