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Copyright (c) 2024 Nawar A. Sakran, Slim Cherif, Firas Shawqi Algburi
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.The relationship of irisin, apelin-13, and immunological markers il-1α & amp, il-1β with diabetes in kidney failure patients
Corresponding Author(s) : Nawar A. Sakran
Cellular and Molecular Biology,
Vol. 70 No. 12: Issue 12
Abstract
Chronic kidney disease (CKD) is often complicated by diabetes, impacting various biochemical and immunological markers. This study aimed to investigate the relationship between irisin, apelin-13, and immunological markers IL-1α and IL-1β in diabetic patients with CKD. This cross-sectional study was conducted from January to June 2023 in a tertiary care hospital in Tikrit City, Iraq. This study included 120 CKD patients and a control group including 20 healthy individuals. Patients were included in the study by convenience sampling method. Participants were evaluated using ELISA kits for irisin, apelin-13, and cytokines, with blood samples analyzed for relevant biochemical markers. Patients had irisin levels of 10.98 ± 2.5 ng/mL, significantly different from non-diabetic patients (12.40 ± 3.54 ng/mL) and controls (5.36 ± 1.06 ng/mL) (p<0.001). Apelin-13 was higher in diabetic patients (537.71 ± 124.78 pg/mL) compared to controls (181.26 ± 29.98 pg/mL) (p<0.001). IL-1α levels in diabetic patients were 715.30 ± 392.48 pg/mL, significantly higher than in control patients (206.27 ± 26.49 pg/mL) (p<0.001). IL-1β levels were 351.50 ± 81.82 pg/mL in diabetics, also higher than in control (145.79 ± 38.49 pg/mL) (p<0.001). The study highlights significant associations between biochemical markers and CKD in diabetic patients. Elevated levels of irisin, apelin-13, IL-1α, and IL-1β may serve as potential biomarkers for diabetes-related CKD complications.
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