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Copyright (c) 2024 Nawres Abdulameer
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The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Relationships between genetic polymorphisms of IL-1β and rheumatoid arthritis
Corresponding Author(s) : Nawres Adnan Abdulameer
Cellular and Molecular Biology,
Vol. 70 No. 12: Issue 12
Abstract
This study aimed to investigate the association between the interleukin-1 beta (IL-1β) gene polymorphism (rs2853550) and the risk of rheumatoid arthritis (RA) in a sample of the Iraqi population. The study included 100 RA patients and 100 healthy controls. Demographic characteristics, including age and gender, were collected and compared between the two groups. The IL-1β (rs2853550) polymorphism was genotyped using the ARMS-PCR method. The distribution of genotypes and alleles of the IL-1β (rs2853550) polymorphism was significantly different between RA patients and healthy controls. The frequency of the heterozygous AG genotype was significantly higher in the patient group compared to the control group (33% vs. 25%, p=0.001). The odds ratio for RA in individuals with the AG genotype was 1.5038 (95% CI: 0.7274-3.1086), indicating that it may be a potential risk factor. Additionally, the frequency of the G allele was significantly higher in RA patients compared to controls (129 vs. 109, p=0.0021), with an odds ratio of 1.5169 (95% CI: 1.0151-2.2667). The present study demonstrates that the IL-1β (rs2853550) polymorphism is associated with an increased risk of rheumatoid arthritis in the Iraqi population. The AG genotype and the G allele of this polymorphism may serve as genetic markers for susceptibility to RA.
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