Mostafa  Saeedinia; Jiayi  Chen; Omid Kohandel Gargari; Kyana  Jafarabady; Majid Zaki-Dizaji; Alireza Ghorbankhanloo; Zohreh  Heidary

doi:10.14715/cmb/2024.70.7.4

Issue

Vol. 70 No. 7: Issue 7

Issue Published : July 28, 2024

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Epigenetics modification among vitrified oocytes and early embryos derived from them: a narrative review

Epigenetics modification of oocytes and embryos

https://doi.org/10.14715/cmb/2024.70.7.4

Mostafa Saeedinia

Shahid Beheshti University of Medical Sciences, Tehran, Iran

Jiayi Chen

Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, P.R.China

Omid Kohandel Gargari

Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Kyana Jafarabady

Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Majid Zaki-Dizaji

Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Alireza Ghorbankhanloo

Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Zohreh Heidary

Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Corresponding Author(s) : Zohreh Heidary

zheidary2016@gmail.com

Cellular and Molecular Biology, Vol. 70 No. 7: Issue 7
Article Published : July 28, 2024

Abstract

Vitrification has important application in assisted reproductive technology (ART) and this technique has been widely used in the cryopreservation of oocytes and embryos. However, due to susceptibility of epigenetic modifications to environmental changes induced by cryopreservation procedures, there are concerns about the potential epigenetic consequences of oocyte and embryo vitrification. This review comprehensively summarized the effect of cryopreservation—especially the vitrification method in ART-on oocytes and embryos. Various studies have reported changes in different aspects of genomic status which directly affect the quality of fertilized embryos. The objective of this review is to assess existing literature on the epigenetic modifications that occur in vitrified oocytes and early embryos resulting from oocyte vitrification, including DNA modifications, RNA methylation, histone modification and microRNAs related to ART.

Keywords

Assisted reproductive technology oocyte vitrification epigenetic cryopreservation

Saeedinia, M. ., Chen, J. ., Kohandel Gargari, O., Jafarabady, K. ., Zaki-Dizaji, M., Ghorbankhanloo , A., & Heidary, Z. . (2024). Epigenetics modification among vitrified oocytes and early embryos derived from them: a narrative review: Epigenetics modification of oocytes and embryos. Cellular and Molecular Biology, 70(7), 22–28. https://doi.org/10.14715/cmb/2024.70.7.4