Maryam Qais Ahmed; Zainab A  Razak Al-Sharifi; Faiq  Gorial

doi:10.14715/cmb/2023.69.13.22

Issue

Vol. 69 No. 13: Issue 13

Issue Published : December 29, 2023

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Association of soluble triggering receptor expressed on myeloid cells‐1 with rheumatoid arthritis in Iraqi patients: A case-control study

Association of sTREM-1 with RA in Iraqi patients

https://doi.org/10.14715/cmb/2023.69.13.22

Maryam Qais Ahmed

Biochemical Engineering Department, Al-Khwarizmi College of Engineering College, University of Baghdad, Baghdad, Iraq

Zainab A Razak Al-Sharifi

Department of Biochemistry, College of Medicine, University of Baghdad, Baghdad, Iraq

Faiq Gorial

Department of Rheumatology, University of Baghdad-College of Medicine, Baghdad, Iraq

Corresponding Author(s) : Maryam Qais Ahmed

maryam.q@kecbu.uobaghdad.edu.iq

Cellular and Molecular Biology, Vol. 69 No. 13: Issue 13
Article Published : December 10, 2023

Abstract

Rheumatoid arthritis (RA) is a common chronic immune-mediated inflammatory arthritis, impacting 0.5-1% of the global population, and leading to progressive deterioration of the musculoskeletal and joint systems. This study aims to analyze the serum levels of soluble triggering receptors expressed on myeloid cells‐1 (sTREM-1) in Iraqi patients with RA and healthy individuals. It also intends to assess the diagnostic significance of these receptors, investigate their association with disease activity and examine their correlation with the sociodemographic and clinical characteristics of the patients. From December 2020 to June 2021, 117 RA patients with a mean age of 50 years participated in the study. The patients were categorized into inactive and active disease groups based on their DAS28 score and CDAI, as determined by a Rheumatologist. The serum levels of a specific triggering receptor expressed on myeloid cells‐1 (TREM-1) (Pg/mL) were measured. The results showed that the active RA patients had significantly higher levels of the receptor (270.17±187) compared to both the inactive RA patients (112.81±37.48) and the healthy controls (43.89±29.53) (P < 0.001). The sTREM-1 demonstrated a high discriminatory ability (AUC ≥ 0.936) between RA and control groups. Moreover, a direct association was observed between the DAS-28ESR and sTREM-1 levels.

Keywords

Chronic inflammatory Rheumatoid arthritis Soluble triggering receptor Musculoskeletal system Myeloid cells‐1 Disease activity score 28

Qais Ahmed, M., Razak Al-Sharifi, Z. A. ., & Gorial, F. . (2023). Association of soluble triggering receptor expressed on myeloid cells‐1 with rheumatoid arthritis in Iraqi patients: A case-control study: Association of sTREM-1 with RA in Iraqi patients. Cellular and Molecular Biology, 69(13), 142–148. https://doi.org/10.14715/cmb/2023.69.13.22