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Copyright (c) 2023 Alan Hassan, Ali Ahmed Al-Dosky
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Association between vitamin D status and malondialdehyde in T2DM patients with painful diabetic peripheral neuropathy
Corresponding Author(s) : Alan Bapeer Hassan
Cellular and Molecular Biology,
Vol. 69 No. 13: Issue 13
Abstract
The association of vitamin D with oxidative stress in type 2 diabetes mellitus (T2DM) patients with peripheral neuropathy (pDPN) has not been investigated in the literature yet. In this regard, we aimed to investigate the link between vitamin D status and malondialdehyde secretion in T2DM with pDPN. We included the T2DM patients with and without pDPN from a main tertiary medical diabetic center in Duhok City in this case-control investigation from September 2021 to March 2022. The patients aged between 40 and 70 years old. The patients were diagnosed based on the American Diabetes Association criteria. The T2DM patients with pDPN had a significantly lower level of vitamin D (12.10 ng/ml vs. 16.86 ng/ml; P=0.0013.) compared to the patients without compilations, respectively. The T2DM patients with pDPN had a significantly higher prevalence of severe deficiency (45.83% vs. 16.67%), while the patients without compilations had a significantly higher prevalence of deficient vitamin D (50.0% vs. 37.50%; P=0.0053). Moreover, the T2DM patients with pDPN had a significantly higher concentration of MDA compared to the T2DM patients without complications (30.55 nmol/ml vs. 16.6 nmol/ml; P=0.0098). The study did not find a significant correlation between MDA and vitamin D levels in T2DM patients with pDPN. This study showed that a higher concentration of MDA was not associated with lower vitamin D levels in T2DM patients with pDPN.
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