Yang  Liu; Xiangcai  Meng; Xin  Zhang; Li  He; Yimin Wang

doi:10.14715/cmb/2023.69.7.26

Issue

Vol. 69 No. 7: Issue 7

Issue Published : September 13, 2023

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Vitamin D Inhibits Colorectal Cancer Cell Proliferation, Migration and Invasion via Downregulating the Notch1 Pathway

Vitamin D Suppresses CRC via Notch1 Downregulation

https://doi.org/10.14715/cmb/2023.69.7.26

Yang Liu

Department of Surgery, Hebei Medical University, Hebei, 050017, China

Xiangcai Meng

Department of General Surgery The First Hospital of Qinhuangdao, Qinhuangdao 066000, China

Xin Zhang

Department of General Surgery The First Hospital of Qinhuangdao, Qinhuangdao 066000, China

Li He

Department of General Surgery The First Hospital of Qinhuangdao, Qinhuangdao 066000, China

Yimin Wang

Department of Surgery, Hebei Medical University, Hebei, 050017, China

Corresponding Author(s) : Yimin Wang

Qhddrwym@163.com

Cellular and Molecular Biology, Vol. 69 No. 7: Issue 7
Article Published : July 31, 2023

Abstract

Due to its high incidence and mortality rates, colorectal cancer (CRC) has become the focus of research. Vitamin D has anticancer functions in a variety of cancers, but the relationship between vitamin D status and CRC risk and survival is inconclusive. The purpose of this study was to explore the effect of vitamin D on the proliferation and invasion of CRC cells to find an effective way to treat CRC. The results showed that vitamin D could inhibit SW480 cell progression in vitro. The results showed that vitamin D significantly blocked the Notch1 pathways by decreasing NOTCH1 protein expression. In addition, we found that Notch1 overexpression could significantly reverse the inhibitory effect of vitamin D on SW480 cells. These results reveal novel insights into the mechanisms of vitamin D anticancer activity in CRC development and progression.

Keywords

Vitamin D Colorectal Cancer Proliferation Metastasis Notch1

Liu, Y. ., Meng, X. ., Zhang, X. ., He, L. ., & Wang, Y. (2023). Vitamin D Inhibits Colorectal Cancer Cell Proliferation, Migration and Invasion via Downregulating the Notch1 Pathway: Vitamin D Suppresses CRC via Notch1 Downregulation. Cellular and Molecular Biology, 69(7), 164–167. https://doi.org/10.14715/cmb/2023.69.7.26