Pomegranate seed extract attenuates chemotherapy-induced liver damage in an experimental model of rabbits.
Corresponding Author(s) : N. C. Yildirim
Cellular and Molecular Biology,
Vol. 59 No. 2: General Papers
The aim of this study was to determine whether antioxidant pomegranate seed extract (PSE) has a preventive effect on cisplatin-induced hepatotoxicity. Rabbits were divided into 3 groups (n=6):1-Control group (0.9 % saline. i.p) 2-Cisplatin group (a single dose of cisplatin (5 mg/kg, i.p) 3- A single dose of cisplatin (5 mg/kg, i.p) + PSE (250 mg/kg/day, i.p) for 6 consecutive days before and 6 consecutive days after a single intraperitoneal dose of 5 mg/kg body weight cisplatin. Liver function enzymes and malondialdehyde (MDA) levels were found significantly higher in cisplatin group compared to control. Liver catalase (CAT) and glutathione peroxidase (GSH-PX) activities decreased with cisplatin treatment but glutathione (GSH) level was increased. In cisplatin + PSE group, liver function enzyme activities and tissue MDA levels were found lower than cisplatin group. PSE ameliorated cisplatin-induced pathological changes. As a result it was demonstrated that PSE has protective effects against cisplatin hepatotoxicity in rabbit.
Pomegranate seed extract Antioxidant effect Cisplatin Hepatotoxicity Rabbit.
Yildirim, N. C., Kandemir, F. M., Ceribasi, S., Ozkaraca, M., & Benzer, F. (2013). Pomegranate seed extract attenuates chemotherapy-induced liver damage in an experimental model of rabbits. Cellular and Molecular Biology, 59(2), 1842–47. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/466
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