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Vol. 68 No. 9: Issue 9

Issue Published : March 11, 2023
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Telomerase Reverse Transcriptase and Telomerase RNA Component Gene Expression as a Novel Biomarkers for Alzheimer’s disease

Telomerase Gene Expression Levels as Novel Biomarkers of Alzheimer
https://doi.org/10.14715/cmb/2022.68.9.2
Raya Kh. Yashooa
Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, 44001, Kurdistan, Iraq
https://orcid.org/0000-0002-9886-9868
Ari Q. Nabi
Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, 44001, Kurdistan, Iraq
https://orcid.org/0000-0001-6844-1134

Corresponding Author(s) : Ari Q. Nabi

ari.nabi@su.edu.krd

Cellular and Molecular Biology, Vol. 68 No. 9: Issue 9
Article Published : September 30, 2022

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Abstract

Alzheimer's disease (AD) is a neurological, age-related condition that causes cognitive decline and memory loss; it induces dementia in the elderly. Telomerase is a reverse transcriptase ribonucleoprotein that adds nucleotides to the end of DNA. This study aimed to compare human telomerase reverse transcriptase (hTERT) and telomerase RNA component (TERC) expression in different phases of AD and healthy cohorts. Sixty participants were divided into 30 who had dementia and 30 who did not. After collecting blood samples, total RNAs were extracted from the plasma. Screening for hTERT and TERC gene expression was carried out by quantitative reverse transcriptase real-time polymerase chain reaction (RT-qPCR) using the relative quantification method to estimate the expression changes in hTERT and TERC. The RT-qPCR results show that hTERT and TERC gene expression was significantly down-regulated in Alzheimer's patients compared to the health subjects (P-value= <0.0001,0.005), respectively. The area under curve AUC was 0.773 for hTERT and 0.703 for TERC. The Mini-Mental State Examination scores revealed a significant difference between dementia and non-dementia subjects (P=<0.0001). We conclude down-regulations in both hTERT and TERC gene expression in AD patients, which supports our hypothesis that the telomerase expression gene in the blood of AD patients can serve as a non-invasive, early, and novel diagnostic marker of AD.


 

Keywords

Alzheimer, Biomarker, Telomerase, RT-qPCR, hTERT, TERC
Yashooa, R. K., & Nabi, A. Q. . (2022). Telomerase Reverse Transcriptase and Telomerase RNA Component Gene Expression as a Novel Biomarkers for Alzheimer’s disease: Telomerase Gene Expression Levels as Novel Biomarkers of Alzheimer. Cellular and Molecular Biology, 68(9), 14–20. https://doi.org/10.14715/cmb/2022.68.9.2
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Author Biographies

Raya Kh. Yashooa, Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, 44001, Kurdistan, Iraq

MSc student at Biology Department, College of Science, Salahaddin University-Erbil, Erbil 44001, Kurdistan, Iraq.

Ari Q. Nabi, Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, 44001, Kurdistan, Iraq

Dr Ari Nabi; is also known as (Ari Q. Nabi; or Ari Qadir Nabi)

Associate Professor in Molecular Biology at Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, 44001, Kurdistan, Iraq

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