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Copyright (c) 2022 Mingming Gu, Zhubei Chen, Hui Xiong, Kun Liu, Zhangpeng Ye, Qingsheng You
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Role and Clinical Significance of LncRNA16 in the Malignant Proliferation of Lung Cancer Cells
Corresponding Author(s) : Qingsheng You
Cellular and Molecular Biology,
Vol. 68 No. 7: Issue 7
Abstract
The highest mortality rate among cancer patients is lung cancer. A large proportion of cancer patients are lung cancer patients. The incidence rate of lung cancer is the highest in the world. In recent years, long-chain non-coding RNA, or LncRNA, has become more and more closely related to cancer and has gradually attracted the attention of many cancer researchers. LncRNA is the proto-oncogene of cancer. We can find out the cause of cancer and put forward effective methods to inhibit the occurrence of cancer by studying LncRNA. This study aimed to investigate the effect of noncoding long-chain RNA16 on the proliferation and molecular mechanism of lung cancer cells. During the operation, the distance between the excised lung cancer block and the adjacent tissue is 2cm from the corresponding lung cancer block. Then, the total RNA in lung cancer cells and tissues is extracted with a Trizole reagent. Then, the expression profile of LncRNA in three cases of lung cancer and the corresponding adjacent tissue is identified by RNA chip technology. The LncRNA related to proliferation and the expression difference is significant through bioinformatics. The conclusion was that the A549 and H1299 groups of shLncRNA16 could significantly reduce the incidence by 64% and 40% percentage points compared with the experimental group, which indicates that LncRNA16 can be used as a potential treatment target for patients.
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