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Vol. 66 No. 7: Issue 7

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Multi-omics analysis profile oral tumor module clusters to reveal the potential pathogenic mechanism

https://doi.org/10.14715/cmb/2020.66.7.5
Jun Liu
Plastic and Maxillofacial Surgery, Heilongjiang Provincial Hospital, Harbin, 150036, China
Chaoyue Zhao
Department of Prosthodontics, The First Hospital of Harbin, Harbin, 150070, China
Song Yang
Plastic and Maxillofacial Surgery, Heilongjiang Provincial Hospital, Harbin, 150036, China
Chen Dong
Plastic and Maxillofacial Surgery, Heilongjiang Provincial Hospital, Harbin, 150036, China

Corresponding Author(s) : Jun Liu

b1n.yang@yandex.com

Cellular and Molecular Biology, Vol. 66 No. 7: Issue 7

Abstract

Oral tumors are malignant cancers caused by abnormal proliferation or pathological changes of soft or hard tissues in the oral cavity. Serious cases may pose a threat to life. However, its precancerous lesions remain unclear. This study is based on a comprehensive strategy to explore a multi-factor-driven oral cancer barrier module, which is an attempt to describe the pathogenesis of the disease and potential regulatory drugs from a global perspective. Functional disease modules were identified by constructing a protein-specific interaction network in patients' oral tissues. Then, comprehensive pathogenesis was explored through combination with analysis of functional and signaling pathway enrichment, prediction of key regulatory factors. It was found that these specifically expressed proteins and their interactions often play a pivotal part in oral tumors. This is reflected in the results of functional and pathway enrichment of modulating genes, which show that they are mainly involved in various immune responses, inflammatory reactions, oral plaque, and oral ulcer-related regulatory processes. This may represent the potential pathogenesis of oral tumors. On the predictive analysis of regulators, a series of ncRNAs (including miR-590, CRNDE and miR-340) and transcription factors (including E2F1, MYC and TP53) were identified that have potential important regulatory effects on oral tumors. These key regulators may manipulate a crucial part of the module sub-network and then work together to mediate the occurrence of oral tumors. On the comprehensive Multi-omics module analysis, the specific proteins and their interactions in patients' oral tissues were identified, while the prominent pivotal regulators were involved in the different pathogenic functions of oral tumors.

Keywords

Oral tumors Immune response Pivotal regulators Pathogenic mechanism ncRNA Transcription factor.
Liu, J., Zhao, C., Yang, S., & Dong, C. (2020). Multi-omics analysis profile oral tumor module clusters to reveal the potential pathogenic mechanism. Cellular and Molecular Biology, 66(7), 24–30. https://doi.org/10.14715/cmb/2020.66.7.5
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References
  1. Kazemi E, Kahrizi D, Moradi M, Sohrabi M, Yari K. Gastric cancer and helicobacter pylori: impact of hopQII gene. Cell Mol Biol. 2016; 62(2): 107-110.
  2. Kazemi E, Kahrizi D, Moradi M, Sohrabi M, Amini S, Mousavi S, Yari K. Association between Helicobacter pylori hopQI genotypes and human gastric cancer risk. Cell Mol Biol. 2016; 62(1): 6-9.
  3. Ismaili A, Yari K, Moradi M-T, Sohrabi M, Kahrizi D, Kazemi E, Souri Z. IL-1B (C+ 3954T) gene polymorphism and susceptibility to gastric cancer in the Iranian population. Asian Pac J Cancer Prev. 2015; 16: 841-844.
  4. Kazemi E, Kahrizi D. Lack of association between gastric cancer and hopQ alleles in Helicobacter pylori. Genetika. 2016; 48(3): 893-902.
  5. Kazemi E, Moradi M, Yari K, Mousavi S, Kahrizi D. Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease. Cell Mol Biol. 2015; 61(8): 49-52.
  6. Darvishi E, Aziziaram Z, Yari K, Dehbaghi MB, Kahrizi D, Karim H, Vaziri S, Zargooshi J, Ghadiri K, Muhammadi S. Lack of association between the TNF-α-1031genotypes and generalized aggressive periodontitis disease. Cell Mol Biol. 2016; 62(11): 63-66.
  7. Gholizadeh P, Eslami H, Yousefi M, Asgharzadeh M, Aghazadeh M, Kafil HS. Role of oral microbiome on oral cancers, a review. Biomed Pharmacother. Dec 2016; 84: 552-558.
  8. Markopoulos AK. Current aspects on oral squamous cell carcinoma. Open Dent J. 2012; 6: 126-130.
  9. Pereira LO, Bicalho LS, Campos-da-Paz Lopes M, de Sousa TM, Bao SN, de Fatima Menezes Almeida Santos M, Fonseca MJ. DNA damage and apoptosis induced by Pteridium aquilinum aqueous extract in the oral cell lines HSG and OSCC-3. J Oral Pathol Med. May 2009; 38(5): 441-447.
  10. Huber MA, Tantiwongkosi B. Oral and oropharyngeal cancer. Med Clin North Am. Nov 2014; 98(6): 1299-1321.
  11. Campbell BR, Netterville JL, Sinard RJ, Mannion K, Rohde SL, Langerman A, Kim YJ, Lewis JS, Jr., Lang Kuhs KA. Early onset oral tongue cancer in the United States: A literature review. Oral Oncol. Dec 2018; 87: 1-7.
  12. Sievilainen M, Almahmoudi R, Al-Samadi A, Salo T, Pirinen M, Almangush A. The prognostic value of immune checkpoints in oral squamous cell carcinoma. Oral Dis. Oct 13 2018.
  13. Zheng JW, Yang Y, Yang S, Zhou W, Qiu H, Li X, Cai Q, Li T, Luo G. Gene microarray analysis revealed a potential crucial gene RACK1 in oral squamous cell carcinoma (OSCC). Anim Cells Syst (Seoul). 2018; 22(2): 82-91.
  14. Yao Y, Zhou WY, He RX. Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-kappaB pathway. Biomed Pharmacother. Jan 2019; 109: 1994-2004.
  15. Masumoto K, Kitagawa M. E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers. Curr Cancer Drug Targets. 2016; 16(2): 130-135.
  16. Valverde Lde F, Pereira Tde A, Dias RB, Guimaraes VS, Ramos EA, Santos JN, Gurgel Rocha CA. Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. Tumour Biol. Jul 2016; 37(7): 9233-9241.
  17. Lee HM, Patel V, Shyur LF, Lee WL. Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells. Phytomedicine. Nov 15 2016; 23(12): 1535-1544.
  18. Deeks ED. Olaparib: first global approval. Drugs. Feb 2015; 75(2): 231-240.
  19. Yasukawa M, Fujihara H, Fujimori H, Kawaguchi K, Yamada H, Nakayama R, Yamamoto N, Kishi Y, Hamada Y, Masutani M. Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. Feb 24 2016; 17(3): 272.
  20. Lebrun C, Rocher F. Cancer Risk in Patients with Multiple Sclerosis: Potential Impact of Disease-Modifying Drugs. CNS Drugs. Oct 2018; 32(10): 939-949.
  21. Syed YY. Rucaparib: First Global Approval. Drugs. Apr 2017; 77(5): 585-592.
  22. Kurnit KC, Coleman RL, Westin SN. Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer. Curr Treat Options Oncol. Nov 15 2018; 19(12): 1.
  23. Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, Yefanov A, Lee H, Zhang N, Robertson CL, Serova N, Davis S, Soboleva A. NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. Jan 2013; 41(Database issue): D991-995.
  24. Huang SH, O'Sullivan B. Oral cancer: Current role of radiotherapy and chemotherapy. Med Oral Patol Oral Cir Bucal. Mar 1 2013; 18(2): e233-240.
  25. Kim W, Zandona ME, Kim SH, Kim HJ. Oral disease-modifying therapies for multiple sclerosis. J Clin Neurol. Jan 2015; 11(1): 9-19.
  26. Baharvand M, Manifar S, Akkafan R, Mortazavi H, Sabour S. Serum levels of ferritin, copper, and zinc in patients with oral cancer. Biomed J. Sep-Oct 2014; 37(5): 331-336.
  27. Rivera C. Essentials of oral cancer. International journal of clinical and experimental pathology. 2015; 8(9): 11884.
  28. Sasahira T, Kirita T. Hallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell Carcinoma. Int J Mol Sci. Aug 16 2018; 19(8).
  29. Petito G, Carneiro MA, Santos SH, Silva AM, Alencar RC, Gontijo AP, Saddi VA. Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil. Braz J Otorhinolaryngol. Jan - Feb 2017; 83(1): 38-44.
  30. Ren Y, He W, Chen W, Ma C, Li Y, Zhao Z, Gao T, Ni Q, Chai J, Sun M. CRNDE promotes cell tongue squamous cell carcinoma cell growth and invasion through suppressing miR-384. J Cell Biochem. Jan 2019; 120(1): 155-163.
  31. Kim H, Yang JM, Ahn SH, Jeong WJ, Chung JH, Paik JH. Potential Oncogenic Role and Prognostic Implication of MicroRNA-155-5p in Oral Squamous Cell Carcinoma. Anticancer Res. Sep 2018; 38(9): 5193-5200.
  32. Pedersen NJ, Jensen DH, Lelkaitis G, Kiss K, Charabi BW, Ullum H, Specht L, Schmidt AY, Nielsen FC, von Buchwald C. MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma. Oral Oncol. Aug 2018; 83: 46-52.
  33. Li X, He J, Shao M, Cui B, Peng F, Li J, Ran Y, Jin D, Kong J, Chang J, Duan L, Yang X, Luo Y, Lu Y, Lin B, Liu T. Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-ROCK signaling. Biomed Pharmacother. Oct 2018; 106: 646-654.
  34. Bordbar M, Darvishzadeh R, Pazhouhandeh M, Kahrizi D. An overview of genome editing methods based on endonucleases. Modern Genetics J. 2020; 15(2): 75-92.
  35. van Ginkel JH, de Leng WW, de Bree R, van Es RJ, Willems SM. Targeted sequencing reveals TP53 as a potential diagnostic biomarker in the post-treatment surveillance of head and neck cancer. Oncotarget. Sep 20 2016; 7(38): 61575-61586.
  36. Martano M, Stiuso P, Facchiano A, De Maria S, Vanacore D, Restucci B, Rubini C, Caraglia M, Ravagnan G, Lo Muzio L. Aryl hydrocarbon receptor, a tumor gradeassociated marker of oral cancer, is directly downregulated by polydatin: A pilot study. Oncol Rep. Sep 2018; 40(3): 1435-1442.
  37. Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH. Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis. Mol Cancer Res. Aug 2016; 14(8): 696-706.
  38. Budhy TI. Molecular Grading of Oral Squamous Cell Carcinomas Infected with EBV. Asian Pac J Cancer Prev. Jul 27 2018; 19(7): 1793-1796.
  39. Ali J, Sabiha B, Jan HU, Haider SA, Khan AA, Ali SS. Genetic etiology of oral cancer. Oral Oncol. Jul 2017; 70: 23-28.
  40. Sawant S, Gokulan R, Dongre H, Vaidya M, Chaukar D, Prabhash K, Ingle A, Joshi S, Dange P, Joshi S, Singh AK, Makani V, Sharma S, Jeyaram A, Kane S, D'Cruz A. Prognostic role of Oct4, CD44 and c-Myc in radio-chemo-resistant oral cancer patients and their tumourigenic potential in immunodeficient mice. Clin Oral Investig. Jan 2016; 20(1): 43-56.
  41. Sharma V, Nandan A, Sharma AK, Singh H, Bharadwaj M, Sinha DN, Mehrotra R. Signature of genetic associations in oral cancer. Tumour Biol. Oct 2017; 39(10): 1010428317725923.
  42. Tsantoulis PK, Kastrinakis NG, Tourvas AD, Laskaris G, Gorgoulis VG. Advances in the biology of oral cancer. Oral Oncol. Jul 2007; 43(6): 523-534.
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