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Vol. 64 No. 14: Issue 14

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Therapeutic and maintenance regimens of vitamin D3 supplementation in healthy adults: A systematic review

https://doi.org/10.14715/cmb/2018.64.14.2
Adla Bakri Hassan
Department of Internal Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Bahrain
Reham Fathi Hozayen
Internal Medicine Department, Salmanyia Medical Complex, Bahrain
Raed Aqshan Alotaibi
Internal Medicine Department, Salmanyia Medical Complex, Bahrain
Yasin Ibrahim Tayem
Department of Pharmacology and Therapeutics, College Of Medicine and Medical Sciences, Arabian Gulf University, Bahrain

Corresponding Author(s) : Adla Bakri Hassan

adla.hassan@gmail.com

Cellular and Molecular Biology, Vol. 64 No. 14: Issue 14

Abstract

Studies carried out assessing the effect of different doses of cholecalciferol (vitamin D3) on correcting serum 25-hydroxyvitamin D deficiency in healthy adults are limited and review studies are lacking. Moreover, the maintenance dose and its duration offered by these few studies are inconsistent. We performed a systematic review of randomized clinical controlled trials (RCTs) that assessed the effect of different doses of vitamin D3 on serum 25(OH)D in healthy adults. PubMed database was searched from 2010 to 2018 using the following search terms: "vitamin D deficiency”, "Cholecalciferol”, "vitamin D3 dose”, "vitamin D supplement”, "vitamin D therapy”. RCTs and original articles that evaluated different doses of vitamin D3 were identified. A total of sixteen (out of 3016) acceptable studies fulfilling our inclusion criteria were included in the current systematic review. Our results revealed that supplementation with vitamin D3 had a significant positive effect in raising serum 25(OH) D concentrations. Our findings indicated that the best regimen of vitamin D3 supplement consisted of an initial large bolus dose either IM injection of 600.000 IU monthly or oral dose of 200.000 IU monthly or 50.000 IU weekly for 8 weeks, followed by a maintenance dose of 50.000 IU monthly or bimonthly. A large bolus therapeutic dose of vitamin D3, frequently or infrequently for 8 weeks, followed by long-term oral maintenance dose of 50.000 IU monthly or bimonthly optimiz and manitain vitamin D serum levels year round.

Keywords

Vitamin D3 deficiency Therapy Maintenance dose.
Hassan, A. B., Hozayen, R. F., Alotaibi, R. A., & Tayem, Y. I. (2018). Therapeutic and maintenance regimens of vitamin D3 supplementation in healthy adults: A systematic review. Cellular and Molecular Biology, 64(14), 8–14. https://doi.org/10.14715/cmb/2018.64.14.2
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References
  1. Rajakumar, K., Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics, 2003. 112(2): p. e132-5.
  2. Zipitis, C.S. and A.K. Akobeng, Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child, 2008. 93(6): p. 512-7.
  3. Garadah, T.S., et al., Predictors of abnormal bone mass density in adult patients with homozygous sickle-cell disease. Clin Med Insights Endocrinol Diabetes. 8: p. 35-40.
  4. Farahati, J., et al., Ethnicity, Clothing Style, and Body Mass Index are Significant Predictors of Vitamin D Insufficiency in Germany. Endocr Pract. 21(2): p. 122-7.
  5. Farid, E., et al., Prevalence of Vitamin D Deficiency in Adult Patients with Systemic Lupus Erythematosus in Kingdom of Bahrain. Egypt J Immunol. 24(2): p. 1-8.
  6. Manoy, P., et al., Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients. 9(8).
  7. Oliveira, S.R., et al., Vitamin D deficiency is associated with disability and disease progression in multiple sclerosis patients independently of oxidative and nitrosative stress. J Neurol Sci. 381: p. 213-219.
  8. Pilz, S., et al., Effects of vitamin D on blood pressure and cardiovascular risk factors: a randomized controlled trial. Hypertension, 2015. 65(6): p. 1195-201.
  9. Barreto, S.G. and R.E. Neale, Vitamin D and pancreatic cancer. Cancer Lett, 2015. 368(1): p. 1-6.
  10. Arul Vijaya Vani, S., et al., Effects of vitamin D and calcium supplementation on side effects profile in patients of breast cancer treated with letrozole. Clin Chim Acta, 2016. 459: p. 53-56.
  11. Ross, A.C., et al., The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 96(1): p. 53-8.
  12. Holick, M.F., et al., Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 96(7): p. 1911-30.
  13. Adami, S., et al., [Guidelines on prevention and treatment of vitamin D deficiency. Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS)]. Reumatismo. 63(3): p. 129-47.
  14. Reid, I.R., D.J. Gallagher, and J. Bosworth, Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure. Age Ageing, 1986. 15(1): p. 35-40.
  15. Cannell, J.J. and B.W. Hollis, Use of vitamin D in clinical practice. Altern Med Rev, 2008. 13(1): p. 6-20.
  16. Holick, M.F., et al., Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab, 2012. 97(4): p. 1153-8.
  17. Cross, H.S. and E. Kallay, Regulation of the colonic vitamin D system for prevention of tumor progression: an update. Future Oncol, 2009. 5(4): p. 493-507.
  18. Khan, A.H., et al., Response of a single 'mega intramuscular dose' of vitamin D on serum 25OHD and parathyroid hormone levels. J Coll Physicians Surg Pak, 2012. 22(4): p. 207-12.
  19. Khan, A.H., et al., No change in calcium absorption in adult Pakistani population before and after vitamin D administration using strontium as surrogate. Osteoporos Int, 2013. 24(3): p. 1057-62.
  20. Priyambada, L., et al., Serum 25 hydroxyvitamin D profile after single large oral doses of cholecalciferol (vitamin D3) in medical staff in North India: a pilot study. J Postgrad Med, 2014. 60(1): p. 52-6.
  21. Nowak, A., et al., Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial. Medicine (Baltimore), 2016. 95(52): p. e5353.
  22. Saleh, L., et al., Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency. Clin Chem Lab Med, 2017. 55(12): p. 1912-1921.
  23. Gowda, U., et al., Efficacy of high dose Vitamin D supplementation in improving serum 25(OH)D among migrant and non migrant population: a retrospective study. BMC Health Serv Res, 2016. 16(1): p. 579.
  24. Gupta, A., et al., Presence of impaired intestinal calcium absorption in chronic hypovitaminosis D and its change after cholecalciferol supplementation: assessment by the calcium load test. J Hum Nutr Diet, 2010. 23(1): p. 54-60.
  25. Rana, P., et al., Effect of vitamin D supplementation on muscle energy phospho-metabolites: a (3)(1)P magnetic resonance spectroscopy-based pilot study. Endocr Res, 2014. 39(4): p. 152-6.
  26. Harris, R.A., et al., Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults. Am J Hypertens, 2011. 24(5): p. 557-62.
  27. Mazahery, H., W. Stonehouse, and P.R. von Hurst, The effect of monthly 50,000 IU or 100,000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland. Eur J Clin Nutr, 2015. 69(3): p. 367-72.
  28. Schleck, M.L., et al., A Randomized, Double-Blind, Parallel Study to Evaluate the Dose-Response of Three Different Vitamin D Treatment Schemes on the 25-Hydroxyvitamin D Serum Concentration in Patients with Vitamin D Deficiency. Nutrients, 2015. 7(7): p. 5413-22.
  29. Khawaja, N., et al., Vitamin D Dosing Strategies Among Jordanians With Hypovitaminosis D. J Pharm Pract, 2017. 30(2): p. 172-179.
  30. Yao, P., et al., Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation. J Clin Endocrinol Metab, 2017. 102(1): p. 100-110.
  31. Green, T.J., C.M. Skeaff, and J.E. Rockell, Milk fortified with the current adequate intake for vitamin D (5 microg) increases serum 25-hydroxyvitamin D compared to control milk but is not sufficient to prevent a seasonal decline in young women. Asia Pac J Clin Nutr, 2010. 19(2): p. 195-9.
  32. Osmancevic, A., et al., Vitamin D treatment in Somali women living in Sweden - Two randomized, placebo-controlled studies. Clin Endocrinol (Oxf), 2016. 85(4): p. 535-43.
  33. Gallagher, J.C., P.S. Jindal, and L.M. Smith, Vitamin D supplementation in young White and African American women. J Bone Miner Res, 2014. 29(1): p. 173-81.
  34. Dawodu, A., et al., Diet, clothing, sunshine exposure and micronutrient status of Arab infants and young children. Ann Trop Paediatr, 2001. 21(1): p. 39-44.
  35. Larrosa, M., et al., [Prevalence of hypovitaminosis D in elderly institutionalized residents: influence of a substitutive treatment]. Med Clin (Barc), 2001. 117(16): p. 611-4.
  36. Vieth, R., Why the minimum desirable serum 25-hydroxyvitamin D level should be 75 nmol/L (30 ng/ml). Best Pract Res Clin Endocrinol Metab. 25(4): p. 681-91.
  37. Duque, G., et al., Vitamin D, bones and muscle: myth versus reality. Australas J Ageing. 36 Suppl 1: p. 8-13.
  38. Tripkovic, L., et al., Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr, 2012. 95(6): p. 1357-64.
  39. Gasier, H.G., et al., The efficacy of vitamin D supplementation during a prolonged submarine patrol. Calcif Tissue Int. 95(3): p. 229-39.
  40. Venugopal, Y., et al., Maintenance vitamin D3 dosage requirements in Chinese women with post menopausal osteoporosis living in the tropics. Asia Pac J Clin Nutr, 2017. 26(3): p. 412-420.
  41. Verrusio, W., et al., Hypovitaminosis D: which oral supplement therapy? J Nutr Health Aging, 2014. 18(4): p. 449-50.
  42. Luger, M., et al., Vitamin D3 Loading Is Superior to Conventional Supplementation After Weight Loss Surgery in Vitamin D-Deficient Morbidly Obese Patients: a Double-Blind Randomized Placebo-Controlled Trial. Obes Surg, 2017. 27(5): p. 1196-1207.
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