MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase

Hui-Zhen Jia; Sheng-Lin Liu; Yan-Fen Zou; Xiao-Fan Chen; Lin Yu; Jun Wan; Hong-Yu Zhang; Qi Chen; Yi Xiong; Bo Yu; Wei Zhang

doi:10.14715/cmb/2018.64.3.17

Issue

Vol. 64 No. 3: Issue 3

Issue Published : March 3, 2018

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase

https://doi.org/10.14715/cmb/2018.64.3.17

Hui-Zhen Jia

Shenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, Guangdong Province, China

Sheng-Lin Liu

Yan-Fen Zou

Department of Dermatology, Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Shenzhen 518036, Guangdong Province, China

Xiao-Fan Chen

Lin Yu

Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China

Jun Wan

Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University - the Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, Guangdong Province, China

Hong-Yu Zhang

Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China

Qi Chen

Yi Xiong

Bo Yu

Department of Dermatology, Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Shenzhen 518036, Guangdong Province, China

Wei Zhang

Corresponding Author(s) : Wei Zhang

zhangweispace@yeah.net

Cellular and Molecular Biology, Vol. 64 No. 3: Issue 3
Article Published : February 28, 2018

Abstract

Atopic dermatitis (AD) is one of the most prevalent skin diseases around the world. Excessive histamine plays a critical role as an inflammatory factor in the pathogenesis of AD. Deregulated microRNAs (miRNAs) were involved in atopic dermatitis by targeting various genes. MiR-223 had been reported to play a vital role in hematopoiesis. In this study, we identified upregulated miR-223 in the whole blood cells of a large group of AD patients. What's more, we found for the first time that one of the major histamine degradation enzymes, histamine-N-methyltransferase (HNMT), was increased in AD patients and AD model mice. Although there was one miR-223 binding site in the 3'- untranslated region of the HNMT gene, HNMT were not inhibited by miR-223. Taken together, it suggested that miR-223 participates in AD through upregulating HNMT indirectly to degrade the excessive histamine.

Keywords

Atopic dermatitis Histamine-N-methyltransferase Micro RNAs miR-223.

Jia, H.-Z., Liu, S.-L., Zou, Y.-F., Chen, X.-F., Yu, L., Wan, J., Zhang, H.-Y., Chen, Q., Xiong, Y., Yu, B., & Zhang, W. (2018). MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase. Cellular and Molecular Biology, 64(3), 103–107. https://doi.org/10.14715/cmb/2018.64.3.17

Download Citation

References

Barton M and Sidbury R. Advances in understanding and managing atopic dermatitis. F1000Res 2015; 4
Furukawa F, Yoshimasu T, Yamamoto Y, Kanazawa N and Tachibana T. Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice. Autoimmun Rev 2009; 8: 495-9.
Brown DD, Tomchick R and Axelrod J. The distribution and properties of a histamine-methylating enzyme. J Biol Chem 1959; 234: 2948-50.
Kuefner MA, Feurle J, Petersen J, Uder M and Schwelberger HG. Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro. Allergol Immunopathol 2014; 42: 324-8.
Carthew RW and Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-55.
Ebert Margaret S and Sharp Phillip A. Roles for MicroRNAs in Conferring Robustness to Biological Processes. Cell 2012; 149: 515-24.
Lu TX and Rothenberg ME. Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. Journal of Allergy and Clinical Immunology 2013; 132: 3-13.
Haneklaus M, Gerlic M, O'Neill LA and Masters SL. miR-223: infection, inflammation and cancer. J Intern Med 2013; 274: 215-26.
Sonkoly E, Janson P, Majuri ML, Savinko T, Fyhrquist N, Eidsmo L, et al., MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J Allergy Clin Immunol 2010; 126: 581-9 e1-20.
Rossbach K, Schaper K, Kloth C, Gutzmer R, Werfel T, Kietzmann M, et al., Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis. Allergy 2016; 71: 189-97.
Imig J, Motsch N, Zhu JY, Barth S, Okoniewski M, Reineke T, et al., microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma. Nucleic Acids Res 2011; 39: 1880-93.
Lu TX, Lim EJ, Besse JA, Itskovich S, Plassard AJ, Fulkerson PC, et al., MiR-223 deficiency increases eosinophil progenitor proliferation. J Immunol 2013; 190: 1576-82.
Kohda F, Koga T, Uchi H, Urabe K and Furue M. Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-c and IL-4 in human keratinocytes. J Dermatol Sci 2002; 28: 34-41.
Lee HS, Kim SH, Kim KW, Baek JY, Park HS, Lee KE, et al., Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in korean children. Allergy Asthma Immunol Res 2012; 4: 31-6.
Preuss CV, Wood TC, Szumlanski CL, Raftogianis RB, Otterness DM, Girard B, et al., Human Histamine N-Methyltransferase Pharmacogenetics Common Genetic Polymorphisms that Alter Activity. Mol Pharmacol 1998; 53:708-17.

References

Barton M and Sidbury R. Advances in understanding and managing atopic dermatitis. F1000Res 2015; 4

Furukawa F, Yoshimasu T, Yamamoto Y, Kanazawa N and Tachibana T. Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice. Autoimmun Rev 2009; 8: 495-9.

Brown DD, Tomchick R and Axelrod J. The distribution and properties of a histamine-methylating enzyme. J Biol Chem 1959; 234: 2948-50.

Kuefner MA, Feurle J, Petersen J, Uder M and Schwelberger HG. Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro. Allergol Immunopathol 2014; 42: 324-8.

Carthew RW and Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-55.

Ebert Margaret S and Sharp Phillip A. Roles for MicroRNAs in Conferring Robustness to Biological Processes. Cell 2012; 149: 515-24.

Lu TX and Rothenberg ME. Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. Journal of Allergy and Clinical Immunology 2013; 132: 3-13.

Haneklaus M, Gerlic M, O'Neill LA and Masters SL. miR-223: infection, inflammation and cancer. J Intern Med 2013; 274: 215-26.

Sonkoly E, Janson P, Majuri ML, Savinko T, Fyhrquist N, Eidsmo L, et al., MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J Allergy Clin Immunol 2010; 126: 581-9 e1-20.

Rossbach K, Schaper K, Kloth C, Gutzmer R, Werfel T, Kietzmann M, et al., Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis. Allergy 2016; 71: 189-97.

Imig J, Motsch N, Zhu JY, Barth S, Okoniewski M, Reineke T, et al., microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma. Nucleic Acids Res 2011; 39: 1880-93.

Lu TX, Lim EJ, Besse JA, Itskovich S, Plassard AJ, Fulkerson PC, et al., MiR-223 deficiency increases eosinophil progenitor proliferation. J Immunol 2013; 190: 1576-82.

Kohda F, Koga T, Uchi H, Urabe K and Furue M. Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-c and IL-4 in human keratinocytes. J Dermatol Sci 2002; 28: 34-41.

Lee HS, Kim SH, Kim KW, Baek JY, Park HS, Lee KE, et al., Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in korean children. Allergy Asthma Immunol Res 2012; 4: 31-6.

Preuss CV, Wood TC, Szumlanski CL, Raftogianis RB, Otterness DM, Girard B, et al., Human Histamine N-Methyltransferase Pharmacogenetics Common Genetic Polymorphisms that Alter Activity. Mol Pharmacol 1998; 53:708-17.

Author biographies is not available.