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Vol. 63 No. 5: Issue 5

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Preparation and properties of polyvinyl alcohol (PVA) and hydroxylapatite (HA) hydrogels for cartilage tissue engineering

https://doi.org/10.14715/cmb/2017.63.5.7
F. Yuan
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
M. Ma
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
L. Lu
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
Z. Pan
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
W. Zhou
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
J. Cai
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
S. Luo
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
W. Zeng
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China
F. Yin
Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji Hospital, Shanghai, China

Corresponding Author(s) : F. Yin

yinfeng_150@163.com

Cellular and Molecular Biology, Vol. 63 No. 5: Issue 5

Abstract

A novel bioactive hydrogel for cartilage tissue based on polyvinyl alcohol (PVA) and hydroxylapatite (HA) were prepared, the effects of its component contents on the mechanical properties and microstructure of the hydrogel were investigated. The important properties of the scaffold composites, such as density, porosity, compressive modulus and microstructure were studied and analyzed through various measurements and methods. The biodegradability of hydrogel was evaluated by soaking the samples into artificial degradation solution at body temperature (36 - 37 oC) in vitro. Experimental results showed that the PVA/HA hydrogels had a density of 0.572 - 0.683 g/cm3, a porosity of 63.25 - 96.14% and a compressive modulus of 5.62 - 8.24 MP. The HA compound in the hydrogels enhanced the biodegradation significantly and linearly increased the rate of biodegradation by 2.3 - 8.5 %. The compressive modulus of PVA/HA exhibited a linear reduce to 0.86 - 1.53 MP with the time of degradation. The scaffold composites PVA/HA possess a high porosity, decent compressive modulus and good biodegradability. After further optimizing the structure and properties, this composite might be considered as novel hydrogel biomaterials to be applied in the field of cartilage tissue engineering.

Keywords

Polyvinyl alcohol Hydroxylapatite Artificial cartilage Biodegradability.
Yuan, F., Ma, M., Lu, L., Pan, Z., Zhou, W., Cai, J., Luo, S., Zeng, W., & Yin, F. (2017). Preparation and properties of polyvinyl alcohol (PVA) and hydroxylapatite (HA) hydrogels for cartilage tissue engineering. Cellular and Molecular Biology, 63(5), 32–35. https://doi.org/10.14715/cmb/2017.63.5.7
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References
  1. Ratner, B. D., & Hoffman, A. S. (2002). Synthetic hydrogels for biomedical applications. Advanced Drug Delivery Reviews, 54(1), 3-12.
  2. Stammen, J. A., Williams, S., Ku, D. N., & Guldberg, R. E. (2001). Mechanical properties of a novel pva hydrogel in shear and unconfined compression. Biomaterials, 22(8), 799–806.
  3. Ducheyne, P., & Qiu, Q. (1999). Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials, 20(24), 2287-2303.
  4. Zheng, Y., Wang, Y. J., Chen, X., Qing, L., & Yang, H. (2007). Preparation and characterization of poly(vinyl alcohol)/hydroxylapatite hybrid hydrogels. Journal of Composite Materials, 41(17), 2071-2082.
  5. Zheng, Y., Yi, L. U., Wang, Y., Liu, Q., & Gang, W. U. (2002). Structure and properties of bioactive compound hydrogels made from poly(vinyl alcohol). Materials Science & Engineering, 20(2), 170-172.
  6. Yan, H., Jin, B., Gao, S., & Chen, L. (2014). Equilibrium swelling and electrochemistry of polyampholytic ph-sensitive hydrogel. International Journal of Solids & Structures, 51(23–24), 4149-4156.
  7. Vaz, C. M., Reis, R. L., & Cunha, A. M. (2002). Use of coupling agents to enhance the interfacial interactions in starch-evoh/hydroxylapatite composites. Biomaterials, 23(2), 629-35.
  8. Saralidze, K., Koole, L. H., & Knetsch, M. L. W. (2010). Polymeric microspheres for medical applications. Materials, 3(6), 3537-3564.
  9. Pramanik, N., Mohapatra, S., Alam, S., & Pramanik, P. (2008). Synthesis of hydroxyapatite/poly(vinyl alcohol phosphate) nanocomposite and its characterization. Polymer Composites, 29(4), 429–436.
  10. Bundela, H., & Bharadwaj, V. (2012). Synthesis and characterization of hydroxyapatite-poly-(vinyl alcohol) based nanocomposites for their perspective use as bone substitutes. Polymer Science Series A, 54(4), 299-309.
  11. Zeng, S., Fu, S., Guo, G., Liang, H., Qian, Z., & Tang, X., et al. (2011). Preparation and characterization of nano-hydroxyapatite/poly(vinyl alcohol) composite membranes for guided bone regeneration. Journal of Biomedical Nanotechnology, 7(4), 549-557.
  12. Kumar, A., Negi, Y. S., Choudhary, V., & Bhardwaj, N. K. (2014). Microstructural and mechanical properties of porous biocomposite scaffolds based on polyvinyl alcohol, nano-hydroxyapatite and cellulose nanocrystals. Cellulose, 21(5), 3409-3426.
  13. Valenzuela, F., Covarrubias, C., Martí­nez, C., Smith, P., Dí­az-Dosque, M., & Yazdani-Pedram, M. (2012). Preparation and bioactive properties of novel bone-repair bionanocomposites based on hydroxyapatite and bioactive glass nanoparticles. Journal of Biomedical Materials Research Part B Applied Biomaterials, 100(6), 1672-82.
  14. Mollazadeh, S., Javadpour, J., & Khavandi, A. (2007). Biomimetic synthesis and mechanical properties of hydroxyapatite/poly (vinyl alcohol) nanocomposites. British Ceramic Transactions, 106(4), 165-170.
  15. Tudorachi, N., & Chiriac, A. P. (2011). Poly(vinyl alcohol-co-lactic acid)/hydroxyapatite composites: synthesis and characterization. Journal of Polymers and the Environment, 19(2), 546-558.
  16. Pramanik, N., Mohapatra, S., Alam, S., & Pramanik, P. (2008). Synthesis of hydroxyapatite/poly(vinyl alcohol phosphate) nanocomposite and its characterization. Polymer Composites, 29(4), 429–436.
  17. Pramanik, N., Mohapatra, S., Bhargava, P., & Pramanik, P. (2009). Chemical synthesis and characterization of hydroxyapatite (hap)-poly (ethylene co vinyl alcohol) (eva) nanocomposite using a phosphonic acid coupling agent for orthopedic applications. Materials Science & Engineering C, 29(1), 228-236.
  18. Pan, Y., & Xiong, D. (2009). Study on compressive mechanical properties of nanohydroxyapatite reinforced poly(vinyl alcohol) gel composites as biomaterial. Journal of Materials Science: Materials in Medicine, 20(6), 1291-1297.
  19. Suciu, A. N., Iwatsubo, T., Matsuda, M., & Nishino, T. (2004). A study upon durability of the artificial knee joint with pva hydrogel cartilage. Jsme International Journal, 47(47), 199-208.
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