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Vol. 68 No. 6: Issue 6

Issue Published : October 7, 2022
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma

LINC0196/miR-584-5p/miR-34a-5p/TRIM59 and Pediatric Neuroblastoma
https://doi.org/10.14715/cmb/2022.68.6.19
Pengfei Xie
Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, 255022, Shandong Province, China
Zhen Wang
Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, 255022, Shandong Province, China
Xia Chen
Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, 255022, Shandong Province, China
Ying Han
Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, 255022, Shandong Province, China
Mei Yang
Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, 255022, Shandong Province, China
Zhuang Ye
Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, 255022, Shandong Province, China

Corresponding Author(s) : Zhuang Ye

yezhuang2022@yandex.com

Cellular and Molecular Biology, Vol. 68 No. 6: Issue 6
Article Published : June 30, 2022

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Abstract

This work was to study the regulatory mechanism of large intergenic non-coding RNA 0196 (LINC0196), miR-584-5p, miR-34a-5p, and tripartite motif 59 (TRIM59) on neuroblastoma. The interaction among the four was analyzed to provide a research basis for the clinical treatment of neuroblastoma at the molecular level. The human neuroblastoma SK-N-SH cells were collected and cultured. According to the transfection methods, the cells were divided into control group (without any treatment), si-LINC0196 group (si-LINC0196 transfection), si-LINC0196-NC group (si-LINC0196 vector transfection), miR-584-5p group (miR-584-5p mimic transfection), miR-584-5p-NC group (miR-584-5p inhibitor transfection), miR-34a-5p group (miR-34a-5p mimic transfection), and miR-34a-5p-NC group (miR-34a-5p inhibitor transfection). The proliferation, migration, and apoptosis of SK-N-SH cells in each group were compared. The effects of LINC0196, miR-584-5p, miR-34a-5p, and TRIM59 were evaluated. The expressions of LINC0196 and TRIM59 in SK-N-SH cells in si-LINC0196, miR-584-5p, and miR-34a-5p groups were up-regulated. miR-584-5p and miR-34a-5p in si-LINC0196-NC, miR-584-5p-NC, and miR-34a-5p-NC groups decreased significantly (P < 0.05). The proliferation rate, migration rate, and invasiveness of SK-N-SH cells in miR-584-5p and miR-34a-5p groups were lower than those in si-LINC0196-NC, miR-584-5p-NC, and miR-34a-5p-NC groups, while the apoptosis rate increased (P < 0.05). After miR-584-5p and miR-34a-5p transfections, the relative activities of WT-LINC0196 and WT-TRIM59 dual luciferase were greatly inhibited (P < 0.05). LINC0196 could regulate TRIM59 by regulating miR-584-5p and miR-34a-5p, thereby indirectly regulating cell proliferation, apoptosis, migration, and invasion of SK-N-SH cells.

Keywords

large intergenic non-coding RNA 0196 (LINC0196) miR-584-5p miR-34a-5 p tripartite motif 59 (TRIM59) neuroblastoma SK-N-SH
Xie, P., Wang, Z., Chen, X., Han, Y., Yang, M., & Ye, Z. (2022). Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma: LINC0196/miR-584-5p/miR-34a-5p/TRIM59 and Pediatric Neuroblastoma. Cellular and Molecular Biology, 68(6), 117–123. https://doi.org/10.14715/cmb/2022.68.6.19
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