Effect of resveratrol administration on muscle glycogen levels in rats subjected to acute swimming exercise

Mursel Bicer; Saltuk Bugra Baltaci; Rasim Mogulkoc; Abdulkerim Kasim Baltaci; Mustafa Cihat Avunduk

doi:10.14715/cmb/2019.65.2.5

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Vol. 65 No. 2: Issue 2

Issue Published : March 12, 2019

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Effect of resveratrol administration on muscle glycogen levels in rats subjected to acute swimming exercise

https://doi.org/10.14715/cmb/2019.65.2.5

Mursel Bicer

School of Physical Education and Sports, Gaziantep University, Gaziantep, Turkey

Saltuk Bugra Baltaci

Faculty of Medicine, Department of Physiology, Selçuk University, Konya, Turkey

Rasim Mogulkoc

Faculty of Medicine, Department of Physiology, Selçuk University, Konya, Turkey

Abdulkerim Kasim Baltaci

School of Physical Education and Sports, Gaziantep University, Gaziantep, Turkey

Mustafa Cihat Avunduk

Faculty of Meram Medicine, Department of Pathology, Necmettin Erbakan University, Konya-Turkey

Corresponding Author(s) : Saltuk Bugra Baltaci

saltukbugrabaltaci@selcuk.edu.tr

Cellular and Molecular Biology, Vol. 65 No. 2: Issue 2
Article Published : February 28, 2019

Abstract

The present study aims to examine how resveratrol administration affects muscle glycogen levels in rats subjected to an acute swimming exercise bout. The study was conducted on adult male rats of Wistar-Albino. The 28 rats used in the study were equally divided among four groups: Group 1, Control Group: The group fed on a standard diet and not subjected to any procedure. Group 2, Control Swimming Group: The group fed on a standard diet and subjected to an acute swimming exercise bout for 30 minutes at the end of the study. Group 3, Resveratrol Group: The group fed on a standard diet and given (10 mg/kg) resveratrol in drinking water for four weeks. Group 4, Resveratrol + Swimming Group: The group fed on a standard diet, given (10 mg/kg) resveratrol in drinking water for four weeks and subjected to a 30-minute acute swimming exercise at the end of the study. At the end of the four weeks, the animals were decapitated, muscle glycogen levels using immunohistochemical method. The highest muscle glycogen levels were obtained in the resveratrol-administered Group 3 and the lowest levels in group 2 (swimming group) (p<0.05). The results of the study demonstrate that resveratrol support had a protective and/or regulatory effect on mucle glycogen in both exercised and not-exercised rats.

Keywords

Swimming exercise Resveratrol Leptin Glycogen Rat.

Bicer, M., Baltaci, S. B., Mogulkoc, R., Baltaci, A. K., & Avunduk, M. C. (2019). Effect of resveratrol administration on muscle glycogen levels in rats subjected to acute swimming exercise. Cellular and Molecular Biology, 65(2), 28–31. https://doi.org/10.14715/cmb/2019.65.2.5

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References

REFERENCES
Dolinsky VW, Dyck JR. Experimental studies of the molecular pathways regulated by exercise and resveratrol in heart,skeletal muscle and the vasculature. Molecules 2014; 19(9):14919-47.
Olas B, Nowak P, Kolodziejczyk J, Ponczek M, Wachowicz B. Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite. J Nutr Biochem 2006;7(2):96-102.
Soleas GJ, Grass L, Josephy PD, Goldberg DM, Diamandis EP. A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin Biochem 2002;35(2):119-124.
Matsumura A, Ghosh A, Pope GS, Darbre PD. Comparative study of oestrogenic-properties of eight phytoestrogens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol 2005;94(5): 431-443.
Tegos G, Stermitz FR, Lomovskaya O, Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother. 2002; 46(10):3133-31341.
Scribbans TD, Ma JK, Edgett BA, Vorobej KA, Mitchell AS, Zelt JG, Simpson CA, Quadrilatero J, Gurd BJ. Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans. Appl Physiol Nutr Metab. 2014;39(11):1305-13.
Ahmad A, Ahmad R. Resveratrol mitigate structural changes and hepatic stellate cell activation in N'-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage. Chem Biol Interact. 2014;221C:1-12.
Wu RE, Huang WC, Liao CC, Chang YK, Kan NW, Huang CC. Resveratrol protects against physical fatigue and improves exercise performance in mice. Molecules. 2013;18(4):4689-702.
Kan NW, Ho CS, Chiu YS, Huang WC, Chen PY, Tung YT, Huang CC. Effects of resveratrol supplementation and exercise training on exercise performance in middle-aged mice. Molecules. 2016;21(5): pii: E661.
Ryan MJ, Jackson JR, Hao Y, Williamson CL, Dabkowski ER, Hollander JM, Alway SE. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol A Biol Sci Med Sci. 2010;65(8):815-31.
Muhammad MH, Allam MM. Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function. J Physiol Sci. 2017 Dec 11. doi: 10.1007/s12576-017-0582-4.
Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R. Of mice and men: The benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev 2012;11:390–398.
Schrauwen P, Timmers S. Can resveratrol help to maintain metabolic health? Proc Nutr Soc 2014;73:271–277.
Dolinsky VW, Jones KE, Sidhu RS, Haykowsky M, Czubryt MP, Gordon T, Dyck JR. Improvements in skeletal muscle strength and cardiac function induced by resveratrol contribute to enhanced exercise performance in rats. J Physiol 2012;590:2783–2799.
Gliemann L, Schmidt JF, Olesen J, Bienso RS, Peronard SL, Grandjean SU, Mortensen SP, Nyberg M, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol 2013;591:5047–5059.
Olesen J, Gliemann L, Bienso R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol 2014;592:1873–1886.
Baltaci SB, Mogulkoc R, Baltaci AK. Resveratrol and exercise. Biomed Rep 2016; 5(5): 525-530.
Jacobs RA, Lundby C. Mitochondria express enhanced quality as well as quantity inassociation with aerobic fitness across recreationally active individuals up to elite athletes. J Appl Physiol 2013;114:344–350.
Holloszy JO, Coyle EF. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 1984;l56:831–838.
Rimbaud S, Ruiz M, Piquereau J, Mateo P, Fortin D, Veksler V, Garnier A, Ventura-Clapier R. Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. PLoS One 2011;6:e26391.
Biala A, Tauriainen E, Siltanen A, Shi J, Merasto S, Louhelainen M, Martonen E, Finckenberg P, et al. Resveratrol induces mitochondrial biogenesis andameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes. Blood Press 2010;19:196–205.
Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 2009;297:H13–H20.
Baltaci AK, Arslangil D, Mogulkoc R, Patlar S. Effect of Resveratrol Administration on the Element Metabolism in the Blood and Brain Tissues of Rats Subjected to Acute Swimming Exercise. Biol Trace Elem Res 2017;175(2):421-427.
Duran MO, Baltaci AK, Mogulkoc R, Avunduk MC, Ergene N. The effect of resveratrol supplementation on plasma leptin and liver glycogen levels in rats with acute swimming exercise. Acta Physiol 2015;215(Suppl 705):87-87.

References

REFERENCES

Dolinsky VW, Dyck JR. Experimental studies of the molecular pathways regulated by exercise and resveratrol in heart,skeletal muscle and the vasculature. Molecules 2014; 19(9):14919-47.

Olas B, Nowak P, Kolodziejczyk J, Ponczek M, Wachowicz B. Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite. J Nutr Biochem 2006;7(2):96-102.

Soleas GJ, Grass L, Josephy PD, Goldberg DM, Diamandis EP. A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin Biochem 2002;35(2):119-124.

Matsumura A, Ghosh A, Pope GS, Darbre PD. Comparative study of oestrogenic-properties of eight phytoestrogens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol 2005;94(5): 431-443.

Tegos G, Stermitz FR, Lomovskaya O, Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother. 2002; 46(10):3133-31341.

Scribbans TD, Ma JK, Edgett BA, Vorobej KA, Mitchell AS, Zelt JG, Simpson CA, Quadrilatero J, Gurd BJ. Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans. Appl Physiol Nutr Metab. 2014;39(11):1305-13.

Ahmad A, Ahmad R. Resveratrol mitigate structural changes and hepatic stellate cell activation in N'-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage. Chem Biol Interact. 2014;221C:1-12.

Wu RE, Huang WC, Liao CC, Chang YK, Kan NW, Huang CC. Resveratrol protects against physical fatigue and improves exercise performance in mice. Molecules. 2013;18(4):4689-702.

Kan NW, Ho CS, Chiu YS, Huang WC, Chen PY, Tung YT, Huang CC. Effects of resveratrol supplementation and exercise training on exercise performance in middle-aged mice. Molecules. 2016;21(5): pii: E661.

Ryan MJ, Jackson JR, Hao Y, Williamson CL, Dabkowski ER, Hollander JM, Alway SE. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol A Biol Sci Med Sci. 2010;65(8):815-31.

Muhammad MH, Allam MM. Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function. J Physiol Sci. 2017 Dec 11. doi: 10.1007/s12576-017-0582-4.

Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R. Of mice and men: The benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev 2012;11:390–398.

Schrauwen P, Timmers S. Can resveratrol help to maintain metabolic health? Proc Nutr Soc 2014;73:271–277.

Dolinsky VW, Jones KE, Sidhu RS, Haykowsky M, Czubryt MP, Gordon T, Dyck JR. Improvements in skeletal muscle strength and cardiac function induced by resveratrol contribute to enhanced exercise performance in rats. J Physiol 2012;590:2783–2799.

Gliemann L, Schmidt JF, Olesen J, Bienso RS, Peronard SL, Grandjean SU, Mortensen SP, Nyberg M, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol 2013;591:5047–5059.

Olesen J, Gliemann L, Bienso R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol 2014;592:1873–1886.

Baltaci SB, Mogulkoc R, Baltaci AK. Resveratrol and exercise. Biomed Rep 2016; 5(5): 525-530.

Jacobs RA, Lundby C. Mitochondria express enhanced quality as well as quantity inassociation with aerobic fitness across recreationally active individuals up to elite athletes. J Appl Physiol 2013;114:344–350.

Holloszy JO, Coyle EF. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 1984;l56:831–838.

Rimbaud S, Ruiz M, Piquereau J, Mateo P, Fortin D, Veksler V, Garnier A, Ventura-Clapier R. Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. PLoS One 2011;6:e26391.

Biala A, Tauriainen E, Siltanen A, Shi J, Merasto S, Louhelainen M, Martonen E, Finckenberg P, et al. Resveratrol induces mitochondrial biogenesis andameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes. Blood Press 2010;19:196–205.

Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 2009;297:H13–H20.

Baltaci AK, Arslangil D, Mogulkoc R, Patlar S. Effect of Resveratrol Administration on the Element Metabolism in the Blood and Brain Tissues of Rats Subjected to Acute Swimming Exercise. Biol Trace Elem Res 2017;175(2):421-427.

Duran MO, Baltaci AK, Mogulkoc R, Avunduk MC, Ergene N. The effect of resveratrol supplementation on plasma leptin and liver glycogen levels in rats with acute swimming exercise. Acta Physiol 2015;215(Suppl 705):87-87.