Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon and at night in young trained male subjects

Oguz Ozcelik; Sermin Algul; Bayram Yilmaz

doi:10.14715/cmb/2018.64.10.21

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Vol. 64 No. 10: Issue 10

Issue Published : August 3, 2018

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Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon and at night in young trained male subjects

https://doi.org/10.14715/cmb/2018.64.10.21

Oguz Ozcelik

Department of Physiology, Faculty of Medicine, University of Firat, Elazig, Turkey

Sermin Algul

Department of Physiology, Faculty of Medicine, University of Van Yuzuncu Yil, Van, Turkey

Bayram Yilmaz

Department of Physiology, Faculty of Medicine, University of Yeditepe, Istanbul, Turkey

Corresponding Author(s) : Sermin Algul

serminalgul@hotmail.com

Cellular and Molecular Biology, Vol. 64 No. 10: Issue 10
Article Published : July 30, 2018

Abstract

This study aimed to investigate the potential effects of acute soccer matches performed in morning, afternoon and at night on both nesfatin-1 and irisin levels in trained subjects. Total of 20 male subjects performed in soccer matches at three different times of day: morning, afternoon, and night. Pre- and post-match venous blood samples were taken, and levels of both nesfatin-1 and irisin were analysed using the enzyme-linked immunosorbent assay (ELISA). Following all matches, the subjects' irisin levels increased significantly in all subjects (p < 0.0001). Nesfatin-1 levels were also increased after the matches; however, the increase was statistically significant for morning (P=0.01) and night-time (p=0.009). The subjects' nesfatin-1 levels did not increase in all subjects and decrease of nesfatin-1 levels observed in some subjects after matches. This study finds that soccer matches performed different workout times have strong stimulatory effects on irisin levels in all subjects but nesfatin-1 response varied among the subjects and it did not change significantly in afternoon match.

Keywords

Energy Irisin Metabolism Nesfatin-1 Soccer match.

Ozcelik, O., Algul, S., & Yilmaz, B. (2018). Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon and at night in young trained male subjects. Cellular and Molecular Biology, 64(10), 130–133. https://doi.org/10.14715/cmb/2018.64.10.21

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References

Stensel D. Exercise, appetite and appetite-regulating hormones: implications for food intake and weight control. Ann Nutr Metab 2010; 57:36-42.
Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443:709-12.
Wernecke K, Lamprecht I, Johren O, Lehnert H, Schulz C. Nesfatin-1 increases energy expenditure and reduces food intake in rats. Obesity (Silver Spring) 2014; 22:1662-8.
Chen X, Shu X, Cong ZK, Jiang ZY, Jiang H. Nesfatin-1 acts on the dopaminergic reward pathway to inhibit food intake. Neuropeptides 2015; 53:45-50.
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-Î±-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481:463-8.
Chen JQ, Huang YY, Gusdon AM, Qu S. Irisin: a new molecular marker and target in metabolic disorder. Lipids Health Dis 2015; 14:2.
Mohebbi H, Nourshahi M, Ghasemikaram M, Safarimosavi S. Effects of exercise at individual anaerobic threshold and maximal fat oxidation intensities on plasma levels of nesfatin-1 and metabolic health biomarkers. J Physiol Biochem 2015; 71:79-88.
Ahmadizad S, Avansar AS, Ebrahim K, Avandi M, Ghasemikaram M. The effects of short-term high-intensity interval training vs. moderate intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers. Horm Mol Biol Clin Investig 2015; 21:165-73.
Ghanbari-Niaki A, Kraemer RR, Soltani R. Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. Eur J Appl Physiol 2010; 110:863-8.
Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biol Sport 2017; 34:339-44.
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012; 61:1725-38.
Kraemer RR, Shockett P, Webb ND, Shah U, Castracane VD. A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Horm Metab Res 2014; 46:150-4.
Stolen T, Chamari K, Castagna C, Wislí¸ff U. Physiology of soccer: an update. Sports Med 2005; 35:501-36.
Mendez-Villanueva A, Buchheit M, Simpson B, Bourdon PC. Match play intensity distribution in youth soccer. Int J Sports Med 2013; 34:101-10.
Algul S, Ozkan Y, Ozcelik O. Serum nesfatin-1 levels in patients with different glucose tolerance levels. Physiol Res 2016; 65:979-85.
Sanchis-Gomar F, Lippi G, Mayero S, Perez-Quilis C, García-Giménez JL. Irisin: a new potential hormonal target for the treatment of obesity and type 2 diabetes. J Diabetes 2012; 4:196.
Spiegelman BM. Banting Lecture 2012: regulation of adipogenesis – toward new therapeutics for metabolic disease. Diabetes 2013; 62:1774-82.
Hojlund K, Bostrom P. Irisin in obesity and type 2 diabetes. J Diabetes Complications 2013; 27:303-4.
Naser N, Ali A, Macadam P. Physical and physiological demands of futsal. J Exerc Sci Fit 2017; 15:76-80.
Hazell TJ, Islam H, Townsend LK, Schmale MS, Copeland JL. Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms. Appetite 2016; 98:80-8.
Ozcelik O, Celik H, Ayar A, Serhatlioglu S, Kelestimur H. Investigation of the influence of training status on the relationship between the acute exercise and serum leptin levels in obese females. Neuro Endocrinol Lett 2004; 25:381-5.
Yazıcı AG. Relationship and interaction between anaerobic sports branches and serum nesfatin-1. Turk J Phys Med Rehab 2015; 61:234-40.
Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y, et al. Fasting concentrations of nesfatin-1 are negatively corre¬lated with body mass index in non-obese males. Clin Endocrinol (Oxf) 2010; 73:484-90.
Chaolu H, Asakawa A, Ushikai M, Li YX, Cheng KC, Li JB, et al. Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp Ther Med 2011; 2:369-73.
Foo KS, Brismar H, Broberger C. Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 2008; 156:63-579.
Sedbazar U, Maejima Y, Nakata M, Mori M, Yada T. Paraventricular NUCB2/nesfatin-1 rises in synchrony with feeding suppression during early light phase in rats. Biochem Biophys Res Commun 2013; 434:434-8.
Winn NC, Grunewald ZI, Liu Y, Heden TD, Nyhoff LM, Kanaley JA. Plasma irisin modestly increases during moderate and high-intensity afternoon exercise in obese females. PLoS One 2017; 12:0170690.
Daskalopoulou SS, Cooke AB, Gomez YH, Mutter AF, Filippaios A, Mesfum ET, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol 2014; 171:343-52.
Czarkowska-Paczek B, Zendzian-Piotrowska M, Gala K, Sobol M, Paczek L. One session of exercise or endurance training does not influence serum levels of irisin in rats. J Physiol Pharmacol 2014; 65:449-54.
Miyamoto-Mikami E, Sato K, Kurihara T, Hasegawa N, Fujie S, Fujita S, et al. Endurance training induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One 2015; 10:0120354.
Löffler D, Müller U, Scheuermann K, Friebe D, Gesing J, Bielitz J, et al. Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab 2015; 100:1289-99.

References

Stensel D. Exercise, appetite and appetite-regulating hormones: implications for food intake and weight control. Ann Nutr Metab 2010; 57:36-42.

Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443:709-12.

Wernecke K, Lamprecht I, Johren O, Lehnert H, Schulz C. Nesfatin-1 increases energy expenditure and reduces food intake in rats. Obesity (Silver Spring) 2014; 22:1662-8.

Chen X, Shu X, Cong ZK, Jiang ZY, Jiang H. Nesfatin-1 acts on the dopaminergic reward pathway to inhibit food intake. Neuropeptides 2015; 53:45-50.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-Î±-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481:463-8.

Chen JQ, Huang YY, Gusdon AM, Qu S. Irisin: a new molecular marker and target in metabolic disorder. Lipids Health Dis 2015; 14:2.

Mohebbi H, Nourshahi M, Ghasemikaram M, Safarimosavi S. Effects of exercise at individual anaerobic threshold and maximal fat oxidation intensities on plasma levels of nesfatin-1 and metabolic health biomarkers. J Physiol Biochem 2015; 71:79-88.

Ahmadizad S, Avansar AS, Ebrahim K, Avandi M, Ghasemikaram M. The effects of short-term high-intensity interval training vs. moderate intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers. Horm Mol Biol Clin Investig 2015; 21:165-73.

Ghanbari-Niaki A, Kraemer RR, Soltani R. Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. Eur J Appl Physiol 2010; 110:863-8.

Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biol Sport 2017; 34:339-44.

Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012; 61:1725-38.

Kraemer RR, Shockett P, Webb ND, Shah U, Castracane VD. A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Horm Metab Res 2014; 46:150-4.

Stolen T, Chamari K, Castagna C, Wislí¸ff U. Physiology of soccer: an update. Sports Med 2005; 35:501-36.

Mendez-Villanueva A, Buchheit M, Simpson B, Bourdon PC. Match play intensity distribution in youth soccer. Int J Sports Med 2013; 34:101-10.

Algul S, Ozkan Y, Ozcelik O. Serum nesfatin-1 levels in patients with different glucose tolerance levels. Physiol Res 2016; 65:979-85.

Sanchis-Gomar F, Lippi G, Mayero S, Perez-Quilis C, García-Giménez JL. Irisin: a new potential hormonal target for the treatment of obesity and type 2 diabetes. J Diabetes 2012; 4:196.

Spiegelman BM. Banting Lecture 2012: regulation of adipogenesis – toward new therapeutics for metabolic disease. Diabetes 2013; 62:1774-82.

Hojlund K, Bostrom P. Irisin in obesity and type 2 diabetes. J Diabetes Complications 2013; 27:303-4.

Naser N, Ali A, Macadam P. Physical and physiological demands of futsal. J Exerc Sci Fit 2017; 15:76-80.

Hazell TJ, Islam H, Townsend LK, Schmale MS, Copeland JL. Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms. Appetite 2016; 98:80-8.

Ozcelik O, Celik H, Ayar A, Serhatlioglu S, Kelestimur H. Investigation of the influence of training status on the relationship between the acute exercise and serum leptin levels in obese females. Neuro Endocrinol Lett 2004; 25:381-5.

Yazıcı AG. Relationship and interaction between anaerobic sports branches and serum nesfatin-1. Turk J Phys Med Rehab 2015; 61:234-40.

Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y, et al. Fasting concentrations of nesfatin-1 are negatively corre¬lated with body mass index in non-obese males. Clin Endocrinol (Oxf) 2010; 73:484-90.

Chaolu H, Asakawa A, Ushikai M, Li YX, Cheng KC, Li JB, et al. Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp Ther Med 2011; 2:369-73.

Foo KS, Brismar H, Broberger C. Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 2008; 156:63-579.

Sedbazar U, Maejima Y, Nakata M, Mori M, Yada T. Paraventricular NUCB2/nesfatin-1 rises in synchrony with feeding suppression during early light phase in rats. Biochem Biophys Res Commun 2013; 434:434-8.

Winn NC, Grunewald ZI, Liu Y, Heden TD, Nyhoff LM, Kanaley JA. Plasma irisin modestly increases during moderate and high-intensity afternoon exercise in obese females. PLoS One 2017; 12:0170690.

Daskalopoulou SS, Cooke AB, Gomez YH, Mutter AF, Filippaios A, Mesfum ET, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol 2014; 171:343-52.

Czarkowska-Paczek B, Zendzian-Piotrowska M, Gala K, Sobol M, Paczek L. One session of exercise or endurance training does not influence serum levels of irisin in rats. J Physiol Pharmacol 2014; 65:449-54.

Miyamoto-Mikami E, Sato K, Kurihara T, Hasegawa N, Fujie S, Fujita S, et al. Endurance training induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One 2015; 10:0120354.

Löffler D, Müller U, Scheuermann K, Friebe D, Gesing J, Bielitz J, et al. Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab 2015; 100:1289-99.

Author biographies is not available.