You Yang; Qingwei Zeng; Shiping Sun; Min Zhang; Wen Liu; Daoliang Song

doi:10.14715/cmb/2022.68.6.13

Issue

Vol. 68 No. 6: Issue 6

Issue Published : October 7, 2022

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Effects of MiR-194-5p on the proliferation and invasion of laryngeal cancer cells by regulating the expression of smurf1 and activating the mTOR signaling pathway

MiR-194-5p effects on the laryngeal cancer cells

https://doi.org/10.14715/cmb/2022.68.6.13

You Yang

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Shanfang Hospital, Beijing, 100027, China

Qingwei Zeng

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Edencare Hospital, Beijing, 100097, China

Shiping Sun

Department of Otolaryngology Head and Neck Surgery, Zibo Central Hospital, Zibo, 3570915, China

Min Zhang

Department of Otolaryngology Head and Neck Surgery, Zibo Central Hospital, Zibo, 3570915, China

Wen Liu

Department of Otolaryngology Head and Neck Surgery, Zibo Central Hospital, Zibo, 3570915, China

Daoliang Song

Department of Otolaryngology Head and Neck Surgery, Zibo Central Hospital, Zibo, 3570915, China

Corresponding Author(s) : Daoliang Song

fanghanpao24581381@163.com

Cellular and Molecular Biology, Vol. 68 No. 6: Issue 6
Article Published : June 30, 2022

Abstract

Laryngeal cancer has become the focus of research because of its high incidence rate and mortality rate. However, the research on miR-194-5p in laryngeal cancer is quite rare. The purpose of this study is to explore the effect of miR-194-5p on the proliferation and invasion of laryngeal cancer cells in order to find an effective way to treat laryngeal cancer. The results showed that miR-194-5p could activate the mTOR signaling pathway by regulating the expression of Smurf1, which had an effect on laryngeal cancer cells. The results showed that the absorbance of the miR-194-5p group was 0.38 lower than that of the NC group, which indicated that up-regulation of mir-194-5p could weaken the proliferation of laryngeal cancer cells. In addition, the average number of laryngeal cancer cells in NC and the miR-194-5p groups was 125.2 and 53.8, respectively, which indicated that miR-194-5p could reduce the number of laryngeal cancer cells passing through the basement membrane and their invasion ability.

Keywords

smurf1 expression laryngeal cancer mir-194-5p mtor research cell proliferation and invasion

Yang, Y., Zeng, Q., Sun, S., Zhang, M., Liu, W., & Song, D. (2022). Effects of MiR-194-5p on the proliferation and invasion of laryngeal cancer cells by regulating the expression of smurf1 and activating the mTOR signaling pathway: MiR-194-5p effects on the laryngeal cancer cells . Cellular and Molecular Biology, 68(6), 79–83. https://doi.org/10.14715/cmb/2022.68.6.13