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Vol. 64 No. 7: Issue 7

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Vitamin D status and oxidative stress in diabetes mellitus

https://doi.org/10.14715/cmb/2018.64.7.11
Wee Chee Lee
Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150 Kota Bharu, Kelantan, Malaysia
Siti Safiah Mokhtar
Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150 Kota Bharu, Kelantan, Malaysia
Seetha Munisamy
Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150 Kota Bharu, Kelantan, Malaysia
Sahran Yahaya
Department of Orthopedics, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150 Kota Bharu, Kelantan, Malaysia
Aida Hanum Ghulam Rasool
Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), 16150 Kota Bharu, Kelantan, Malaysia

Corresponding Author(s) : Wee Chee Lee

vchillie88@gmail.com

Cellular and Molecular Biology, Vol. 64 No. 7: Issue 7

Abstract

Diabetes mellitus is an epidemic that is gaining global concern. Chronic hyperglycemia in diabetes induces the excess production of free radicals. The deleterious effects of excess free radicals are encountered by endogenous antioxidant defense system. Imbalance between free radicals production and antioxidants defense mechanisms leads to a condition known as "oxidative stress”. Diabetes mellitus is associated with augmented oxidative stress that induced micro- and macrovascular complications, which presents a significant risk for cardiovascular events. Low vitamin D levels in the body have also been reported to be associated with the pathogenesis of diabetes and enhanced oxidative stress. The article is to review available literature and summarize the relationship between oxidative stress and vitamin D levels in diabetes. We also review the effects of vitamin D analogs supplementation in improving oxidative stress in diabetics.

Keywords

Vitamin D Oxidative stress Diabetes mellitus Deficiency Supplementation Cardiovascular risk Biomarkers.
Lee, W. C., Mokhtar, S. S., Munisamy, S., Yahaya, S., & Rasool, A. H. G. (2018). Vitamin D status and oxidative stress in diabetes mellitus. Cellular and Molecular Biology, 64(7), 60–69. https://doi.org/10.14715/cmb/2018.64.7.11
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References
  1. Maritim A, Sanders A, Watkins RJ. Diabetes, oxidative stress, and antioxidants: a review. J
  2. Biochem Mol Toxicol 2003; 17(1):24-38.
  3. American Diabetes Association. Classification and diagnosis of diabetes. Diabetes Care 2015; 38(Supp 1):S8-S16.
  4. International Diabetes Federation. IDF Diabetes Atlas 4th, 2010.
  5. International Diabetes Federation. IDF Diabetes Atlas 6th , 2015.
  6. Ministry of Health Malaysia. National Health and Morbidity Survey, 2006.
  7. Ministry of Health Malaysia. National Health and Morbidity Survey, 2015.
  8. Ministry of Health Malaysia. National Health and Morbidity Survey, 2011.
  9. Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev 2013; 93(1):137-88.
  10. Bate KL, Jerums G. Preventing complications of diabetes. Med J Aust 2003; 179(9):498-505.
  11. Geiss LS, Herman WH, Smith PJ. Mortality in non-insulin-dependent diabetes. Diabetes in America 1995; 2:233-55.
  12. Moss SE, Klein R, Klein B. Cause-specific mortality in a population-based study of diabetes. Am J Public Health 1991; 81(9):1158-62.
  13. Moussa S. Oxidative stress in diabetes mellitus. Rom J Biophy 2008; 18(3):225-36.
  14. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40(4):405-12.
  15. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 1999; 48(1):1-9.
  16. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39(1):44-84.
  17. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008; 117(4):503-11.
  18. Halliwell B, Gutteridge J. Free radicals in biology and medicine. Biosciences, Oxford, 2007.
  19. Miwa S, Brand M. Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling. Portland Press Limited, 2003.
  20. Gomes EC, Silva AN, Oliveira MRD. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev 2012.
  21. Rice-Evans C, Miller N, Paganga G. Antioxidant properties of phenolic compounds. Trends Plant Sci 1997; 2(4):152-9.
  22. Pandey KB, Mishra N, Rizvi SI. Protein oxidation biomarkers in plasma of type 2 diabetic patients. Clin Biochem 2010; 43(4):508-11.
  23. Turko IV, Marcondes S, Murad F. Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA: 3-oxoacid CoA-transferase. Am J Physiol Heart Circ Physiol 2001; 281(6):H2289-H94.
  24. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways:a unifying hypothesis of type 2 diabetes. Endocr Rev 2002; 23(5):599-622.
  25. Ullah A, Khan A, Khan MI. Diabetes mellitus and oxidative stress – a concise review. Cell 2015; 92:321-9014220.
  26. Cheeseman K, Slater T. An introduction to free radical biochemistry. Br Med Bull 1993;49(3):481-93.
  27. Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 2005; 4(1):1.
  28. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress− activated signaling pathways mediators of insulin resistance and β-cell dysfunction? Diabetes 2003; 52(1):1-8.
  29. Wolff S. Diabetes mellitus and free radicals - free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br Med Bull 1993;49(3):642-52.
  30. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010; 4(8):118.
  31. Lee WC, Wang CJ, Chen YH, Hsu JD, Cheng SY, Chen HC, et al. Polyphenol extracts from Hibiscus sabdariffa Linnaeus attenuate nephropathy in experimental type 1 diabetes. J Agric Food Chem 2009; 57(6):2206-10.
  32. Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res 2010; 107(9):1058-70.
  33. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008; 4(2):89-96.
  34. Tiwari BK, Pandey KB, Abidi A, Rizvi SI. Markers of oxidative stress during diabetes mellitus. Biomarkers 2013.
  35. Shukla K, Dikshit P, Tyagi MK, Shukla R, Gambhir JK. Ameliorative effect of Withania coagulans on dyslipidemia and oxidative stress in nicotinamide–streptozotocin induced diabetes mellitus. Food Chem Toxicol 2012; 50(10):3595-9.
  36. Kayama Y, Raaz U, Jagger A, Adam M, Schellinger IN, Sakamoto M, et al. Diabetic cardiovascular disease induced by oxidative stress. Int J Mol Sci 2015; 16(10):25234-63.
  37. Patel RH, Tsai R, Orellana A, Cummins CL. Molecular crosstalk between GR and hepatic liver x receptor β (LXRβ) in glucocorticoid induced hyperglycemia. Metabolic & Stress Receptors in Energy Homeostasis: Endocrine Society, 2013, pp. OR23-2-OR-2.
  38. Shab-Bidar S, Neyestani T, Djazayery A. The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial. Eur J Clin Nutr 2015; 69(2):216-22.
  39. Hamden K, Carreau S, Jamoussi K, Miladi S, Lajmi S, Aloulou D, et al. 1α, 25 dihydroxyvitamin D3: therapeutic and preventive effects against oxidative stress, hepatic, pancreatic and renal injury in alloxan-induced diabetes in rats. J Nutr Sci Vitaminol 2009; 55(3):215-22.
  40. Betteridge DJ. What is oxidative stress? Metabolism 2000; 49(2):3-8.
  41. Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J. The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Uni Med J 2012; 12(1):5.
  42. McCord JM. The evolution of free radicals and oxidative stress. Am J Med 2000; 108(8): 652-9.
  43. Bandeira SDM, Guedes GDS, Fonseca LJSD, Pires AS, Gelain DP, Moreira JCF, et al. Characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and SOD activity. Oxid Med Cell Longe 2012.
  44. Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 1993; 57(5):715S-24S.
  45. Shodehinde SA, Oboh G. Antioxidant properties of aqueous extracts of unripe Musa paradisiaca on sodium nitroprusside induced lipid peroxidation in rat pancreas in vitro. Asian Pac J Trop Biomed 2013; 3(6):449-57.
  46. Lefevre G, Beljean-Leymarie M, Beyerle F, Bonnefont-Rousselot D, Cristol J, Therond P, et al., editors. Evaluation of lipid peroxidation by measuring thiobarbituric acid reactive substances. Ann Biol Clin 1997.
  47. Holick MF. Vitamin D: a millenium perspective. J Cell Biochem 2003; 88(2):296-307.
  48. Wacker M, Holick MF. Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation. Nutrients 2013; 5(1):111-48.
  49. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3):266-81.
  50. Juzeniene A, Brekke P, Dahlback A, Andersson-Engels S, Reichrath J, Moan K, et al. Solar radiation and human health. Rep Prog Phys 2011; 74(6):066701.
  51. Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Rheum Dis Clin North Am 2012; 38(1):1-11.
  52. Alshahrani F, Aljohani N. Vitamin D: deficiency, sufficiency and toxicity. Nutrients 2013; 5(9):3605-16.
  53. Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 2008; 88(2):582S-6S.
  54. Heaney RP. Vitamin D:criteria for safety and efficacy. Nutr Rev 2008; 66(Suppl 2):S178-S81.
  55. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7):1911-30.
  56. Bischoff-Ferrari HA. The 25-hydroxyvitamin D threshold for better health. J Steroid Biochem Mol Biol 2007; 103(3):614-9.
  57. Daga RA, Laway BA, Shah ZA, Mir SA, Kotwal SK, Zargar AH. High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India. Arq Bras Endocrinol Metabol 2012; 56(7):423-8.
  58. Al-Othman A, Al-Musharaf S, Al-Daghri NM, Krishnaswamy S, Yusuf DS, Alkharfy KM, et al. Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents. BMC Pediatr 2012; 12(1):92.
  59. Munisamy S, Daud KM, Mokhtar SS, Rasool AH. Effects of 1α"Calcidol (Alfacalcidol) on Microvascular Endothelial Function, Arterial Stiffness, and Blood Pressure in Type II Diabetic Nephropathy Patients. Microcirculation 2016; 23(1):53-61.
  60. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27(12):2813-8.
  61. Krause R, Bühring M, Hopfenmüller W, Holick MF, Sharma AM. Ultraviolet B and blood pressure. Lancet 1998; 352(9129):709-10.
  62. Dong J, Wong SL, Lau CW, Lee HK, Ng CF, Zhang L, et al. Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J 2012; 33(23):2980-90.
  63. Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr 2006; 84(4):694-7.
  64. George N, Kumar TP, Antony S, Jayanarayanan S, Paulose C. Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats. Br J Nutr 2012; 108(08):1410-8.
  65. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009; 94(10):4023-30.
  66. Asemi Z, Hashemi T, Karamali M, Samimi M, Esmaillzadeh A. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am J Clin Nutr 2013; 98(6):1425-32.
  67. Eftekhari MH, Akbarzadeh M, Dabbaghmanesh MH, Hassanzadeh J. The effect of calcitriol on lipid profile and oxidative stress in hyperlipidemic patients with type 2 diabetes mellitus. ARYA Atheroscler 2014; 10(2):82.
  68. Yiu YF, Yiu KH, Siu CW, Chan YH, Li SW, Wong LY, et al. Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes. Atherosclerosis 2013; 227(1):140-6.
  69. Sardar S, Chakraborty A, Chatterjee M. Comparative effectiveness of vitamin D3 and dietary vitamin E on peroxidation of lipids and enzymes of the hepatic antioxidant system in Sprague--Dawley rats. Int J Vitam Nutr Res 1995; 66(1):39-45.
  70. Sugden J, Davies J, Witham M, Morris A, Struthers A. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabetic Med 2008; 25(3):320-5.
  71. Harris RA, Pedersen-White J, Guo DH, Stallmann-Jorgensen IS, Keeton D, Huang Y, et al. Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African American adults. Am J Hypertens 2011; 24(5).
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