The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Estimation of internal exposure to 99Mo in nuclear medicine patients
Corresponding Author(s) : B. M. Dantas
bmdantas@ird.gov.br
Cellular and Molecular Biology,
Vol. 56 No. 2: First symposium on internal dosimetry applied to nuclear medicine (DOSIMN) 2008 Part 2
Abstract
99mTc is the most widely used radionuclide in nuclear medicine. It is obtained by elution of 99Mo-99mTc generators. Depending on the quality of the generator and its integrity, 99Mo may be extracted from the column during the elution process, becoming a radionuclidic impurity in the 99mTc eluate. This fact would impart an unnecessary dose to the patients submitted to diagnostic procedures. The aim of this work is to evaluate 99Mo incorporation and internal effective doses in nuclear medicine patients through bioassay techniques, providing information on the metabolism of molybdenum in humans. A methodology based on in vivo and in vitro measurements was developed. In vivo measurements were performed with a NaI detector installed in the IRD WBC. Urine samples were analysed with a HPGe at the IRD bioassay laboratory. Patients showed detectable activities of 99Mo in whole body and urine. Results were interpreted with AIDE software. Estimated incorporation was compared to predicted values based on ICRP model. Effective doses were in the order of micro sieverts. Results suggest the need to implement a routine quality control program of radionuclidic impurity of 99Mo in 99mTc eluates to be conducted by radiopharmacy laboratories of nuclear medicine centers.
Keywords
Molybdenum
tecnecium
nuclear medicine
internal dosimetry.
Silva, I. C. O. A., Lucena, E. A., Souza, W. O., Dantas, A. L. A., & Dantas, B. M. (2010). Estimation of internal exposure to 99Mo in nuclear medicine patients. Cellular and Molecular Biology, 56(2), 37–40. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/1001
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX